Cannabidiol Exposure During the Mouse Adolescent Period Is Without Harmful Behavioral Effects on Locomotor Activity, Anxiety, and Spatial Memory

Cannabidiol Exposure During the Mouse Adolescent Period Is Without Harmful Behavioral Effects on Locomotor Activity, Anxiety, and Spatial Memory

Cannabidiol (CBD) is a non-intoxicating phytocannabinoid whose purported therapeutic benefits and impression of a high safety profile has promoted its increasing popularity. CBD’s popularity is also increasing among children and adolescents who are being administered CBD, off label, for the treatmen...

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Published in:Frontiers in behavioral neuroscience Vol. 15; p. 711639
Main Authors: Kaplan, J. S., Wagner, J. K., Reid, K., McGuinness, F., Arvila, S., Brooks, M., Stevenson, H., Jones, J., Risch, B., McGillis, T., Budinich, R., Gambell, E., Predovich, B.
Format: Journal Article
Language:English
Published: Lausanne Frontiers Research Foundation 26-08-2021
Frontiers Media S.A
Subjects:
adolescence
Animal behavior
Anxiety
Attention deficit hyperactivity disorder
Autism
Cannabidiol
cannabinoid
Cannabinoids
cannabis
Child development
Cognitive ability
development
Drug dosages
Drug therapy
FDA approval
Laboratory animals
Locomotor activity
Maze learning
Memory
Neuroscience
Open-field behavior
Spatial memory
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Summary:Cannabidiol (CBD) is a non-intoxicating phytocannabinoid whose purported therapeutic benefits and impression of a high safety profile has promoted its increasing popularity. CBD’s popularity is also increasing among children and adolescents who are being administered CBD, off label, for the treatment of numerous symptoms associated with autism spectrum disorder, attention deficit hyperactivity disorder, anxiety, and depression. The relative recency of its use in the adolescent population has precluded investigation of its impact on the developing brain and the potential consequences that may present in adulthood. Therefore, there’s an urgency to identify whether prolonged adolescent CBD exposure has substantive impacts on the developing brain that impact behavioral and cognitive processes in adulthood. Here, we tested the effect of twice-daily intraperitoneal administrations of CBD (20 mg/kg) in male and female C57BL/6J mice during the adolescent period of 25–45 days on weight gain, and assays for locomotor behavior, anxiety, and spatial memory. Prolonged adolescent CBD exposure had no detrimental effects on locomotor activity in the open field, anxiety behavior on the elevated plus maze, or spatial memory in the Barnes Maze compared to vehicle-treated mice. Interestingly, CBD-treated mice had a faster rate of learning in the Barnes Maze. However, CBD-treated females had reduced weight gain during the exposure period. We conclude that prolonged adolescent CBD exposure in mice does not have substantive negative impacts on a range of behaviors in adulthood, may improve the rate of learning under certain conditions, and impacts weight gain in a sex-specific manner.
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Edited by: Robert James McDonald, University of Lethbridge, Canada
Reviewed by: Abdel-Mouttalib Ouagazzal, UMR 7291 Laboratoire de Neurosciences Cognitives (LNC), France; Katerina Antoniou, University of Ioannina, Greece
This article was submitted to Learning and Memory, a section of the journal Frontiers in Behavioral Neuroscience
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2021.711639