Immunogenetic features of apoptosis in workers engaged in methanol production

Disordered cellular death process with inhibition is seen during stress states including occupational activities associated with increased concentrations of methanol in biologic media. Workers exposed to methanol demonstrate prevalence of homozygous type of tumor necrosis factor (TNF) gene and heter...

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Bibliographic Details
Published in:	Meditsina truda i promyshlennaia ekologiia no. 11; p. 9
Main Authors:	Dolgikh, O V, Krivtsov, A V, Bubnova, O A, Predeina, R A, Dianova, D G, Sinitsyna, O O, Maliutina, N N, Taranenko, L A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2013
Subjects:	Adult Apoptosis - genetics Apoptosis - immunology Apoptosis Regulatory Proteins - genetics Chemical Industry - manpower Cytochromes - genetics Humans Immunogenetic Phenomena - genetics Immunogenetic Phenomena - immunology Methanol - toxicity Occupational Diseases - chemically induced Occupational Diseases - genetics Occupational Diseases - immunology Peptide Fragments - genetics Tumor Necrosis Factor-alpha - genetics Tumor Suppressor Protein p53 - genetics
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Summary:	Disordered cellular death process with inhibition is seen during stress states including occupational activities associated with increased concentrations of methanol in biologic media. Workers exposed to methanol demonstrate prevalence of homozygous type of tumor necrosis factor (TNF) gene and heterozygous variant of cytochrome 450 gene, reliably increased vs reference group. Genetic changes in the main group are associated with reliable decrease in occurrence of transcription protein p53 and TNF receptor, and with altered ratio of intracellular apoptosis factors (bax and bcl-2) towards slower programmed cellular death in chemical production.
ISSN:	1026-9428