Efficacy of misoprostol in prevention of gastric hemorrhage in dogs treated with high doses of methylprednisolone sodium succinate

To determine whether administration of misoprostol prevents gastric hemorrhage in healthy dogs treated with high doses of methylprednisolone sodium succinate (MPSS). 18 healthy hound-type dogs of both sexes. All dogs were given high doses of MPSS (30 mg/kg of body weight, initially, then 15 mg/kg 2...

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Bibliographic Details
Published in:	American journal of veterinary research Vol. 60; no. 8; p. 982
Main Authors:	Rohrer, C R, Hill, R C, Fischer, A, Fox, L E, Schaer, M, Ginn, P E, Preast, V A, Burrows, C F
Format:	Journal Article
Language:	English
Published:	United States 01-08-1999
Subjects:	Animals Anti-Ulcer Agents - therapeutic use Biopsy - veterinary Dog Diseases - chemically induced Dog Diseases - physiopathology Dog Diseases - prevention & control Dogs Endoscopy, Gastrointestinal - veterinary Female Gastric Juice Gastrointestinal Hemorrhage - chemically induced Gastrointestinal Hemorrhage - prevention & control Gastrointestinal Hemorrhage - veterinary Male Methylprednisolone Hemisuccinate - adverse effects Misoprostol - therapeutic use Neuroprotective Agents - adverse effects Occult Blood Pylorus - pathology Random Allocation
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Summary:	To determine whether administration of misoprostol prevents gastric hemorrhage in healthy dogs treated with high doses of methylprednisolone sodium succinate (MPSS). 18 healthy hound-type dogs of both sexes. All dogs were given high doses of MPSS (30 mg/kg of body weight, initially, then 15 mg/kg 2 and 6 hours later, and, subsequently, q 6 h for a total of 48 hours) IV. Dogs were assigned randomly to receive concurrent treatment with misoprostol (4 to 6 microg/kg, PO, q 8 h; n = 9) or an empty gelatin capsule (9). Gastroduodenoscopy was performed before and after treatment. Hemorrhage was graded from none (0) to severe (3) for each cardia, fundus, antrum, and duodenum. A total stomach score was calculated as the sum of the regional stomach scores. Food retention was recorded, and pH of gastric fluid was determined. Gastric and fecal occult blood was measured. Gastric hemorrhage was evident in all dogs after MPSS administration, and its severity was similar in both groups. Median total stomach score was 6 for misoprostol-treated dogs and 5.5 for dogs given the gelatin capsule. Difference in gastric acidity, frequency of food retention, and incidence of occult blood in gastric fluid and feces was not apparent between the 2 groups. Administration of misoprostol (4 to 6 microg/kg, PO, q 8 h) does not prevent gastric hemorrhage caused by high doses of MPSS. Alternative prophylactic treatment should be considered.
ISSN:	0002-9645
DOI:	10.2460/ajvr.1999.60.08.982