Search Results - "Prchal, Lukáš"

Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer’s Disease by Rossi, Michele, Freschi, Michela, de Camargo Nascente, Luciana, Salerno, Alessandra, de Melo Viana Teixeira, Sarah, Nachon, Florian, Chantegreil, Fabien, Soukup, Ondrej, Prchal, Lukáš, Malaguti, Marco, Bergamini, Christian, Bartolini, Manuela, Angeloni, Cristina, Hrelia, Silvana, Soares Romeiro, Luiz Antonio, Bolognesi, Maria Laura

“…The multifactorial nature of Alzheimer’s disease (AD) is a reason for the lack of effective drugs as well as a basis for the development of…”
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The Antibacterial Effects of New N-Alkylpyridinium Salts on Planktonic and Biofilm Bacteria by Hympanova, Michaela, Terlep, Saša, Markova, Aneta, Prchal, Lukáš, Dogsa, Iztok, Pulkrabkova, Lenka, Benkova, Marketa, Marek, Jan, Stopar, David

“…An increasing microbial resistance to known antibiotics raises a demand for new antimicrobials. In this study the antimicrobial properties of a series of new N…”
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An efficient synthesis and cytotoxic profile of D-ribo-phytosphingosine and its analogues by Želinská, Milica, Vargová, Kristína, Pončáková, Tatiana, Pilátová, Martina Bago, Martinková, Miroslava, Majirská, Monika, Kuchár, Juraj, Litecká, Miroslava, Prchal, Lukáš

“…In this paper we describe the efficient synthesis of d-ribo-phytosphingosine and its analogues commencing from the easily available l-erythrose chiron, which…”
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Sertraline as a new potential anthelmintic against Haemonchus contortus: toxicity, efficacy, and biotransformation by Zajíčková, Markéta, Prchal, Lukáš, Navrátilová, Martina, Vodvárková, Nikola, Matoušková, Petra, Vokřál, Ivan, Nguyen, Linh Thuy, Skálová, Lenka

“…Haemonchus contortus is a parasitic nematode of ruminants which causes significant losses to many farmers worldwide. Since the drugs currently in use for the…”
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Albendazole in environment: faecal concentrations in lambs and impact on lower development stages of helminths and seed germination by Prchal, Lukáš, Podlipná, Radka, Lamka, Jiří, Dědková, Tereza, Skálová, Lenka, Vokřál, Ivan, Lecová, Lenka, Vaněk, Tomáš, Szotáková, Barbora

“…Albendazole (ABZ), widely used benzimidazole anthelmintic, administered to animals enters via excrements into environment and may impact non-target organisms…”
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Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy on Haemonchus contortus Adults and Eggs, and Their Hepatotoxicity and Biotransformation by Zajíčková, Markéta, Prchal, Lukáš, Vokřál, Ivan, Nguyen, Linh Thuy, Kurz, Thomas, Gasser, Robin, Bednářová, Klára, Mičundová, Magdalena, Lungerich, Beate, Michel, Oliver, Skálová, Lenka

“…As a widely distributed parasitic nematode of ruminants, Haemonchus contortus has become resistant to most anthelmintic classes, there has been a major demand…”
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Biotransformation of anthelmintics and the activity of drug-metabolizing enzymes in the tapeworm Moniezia expansa by Prchal, Lukáš, Bártíková, Hana, Bečanová, Aneta, Jirásko, Robert, Vokřál, Ivan, Stuchlíková, Lucie, Skálová, Lenka, Kubíček, Vladimír, Lamka, Jiří, Trejtnar, František, Szotáková, Barbora

“…The sheep tapeworm Moniezia expansa is very common parasite, which affects ruminants such as sheep, goats as well as other species. The benzimidazole…”
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The metabolism of flubendazole and the activities of selected biotransformation enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics by Vokřál, Ivan, Bártíková, Hana, Prchal, Lukáš, Stuchlíková, Lucie, Skálová, Lenka, Szotáková, Barbora, Lamka, Jiří, Várady, Marián, Kubíček, Vladimír

“…Haemonchus contortus is one of the most pathogenic parasites of small ruminants (e.g. sheep and goat). The treatment of haemonchosis is complicated because of…”
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Reliable reference gene selection for quantitative real time PCR in Haemonchus contortus by Lecová, Lenka, Růžičková, Michaela, Laing, Roz, Vogel, Heiko, Szotáková, Barbora, Prchal, Lukáš, Lamka, Jiří, Vokřál, Ivan, Skálová, Lenka, Matoušková, Petra

“…[Display omitted] •Eleven candidate reference genes were evaluated in Haemonchus contortus adults.•Comparisons were made between sexes, isolates and…”
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Metabolism of drugs and other xenobiotics in giant liver fluke (Fascioloides magna) by Prchal, Lukáš, Vokřál, Ivan, Kašný, Martin, Rejšková, Lenka, Zajíčková, Markéta, Lamka, Jiří, Skálová, Lenka, Lecová, Lenka, Szotáková, Barbora

“…1. Giant liver fluke Fascioloides magna is a dangerous parasite, which infects herbivores. It was imported to Europe from North America and started to spread…”
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Import and efflux of flubendazole in Haemonchus contortus strains susceptible and resistant to anthelmintics by Bártíková, Hana, Vokřál, Ivan, Kubíček, Vladimír, Szotáková, Barbora, Prchal, Lukáš, Lamka, Jiří, Várady, Marián, Skálová, Lenka

“…Drug entry into the body of a helminth is a key factor in the efficacy of anthelmintics. The present project was designed to study the ex vivo uptake and…”
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Ivermectin environmental impact: Excretion profile in sheep and phytotoxic effect in Sinapis alba by Vokřál, Ivan, Michaela, Šadibolová, Radka, Podlipná, Jiří, Lamka, Lukáš, Prchal, Dominika, Sobotová, Kateřina, Lokvencová, Barbora, Szotáková, Lenka, Skálová

“…Ivermectin (IVM), a macrocylic lactone from the avermectin family, is a potent broad-spectrum anthelmintic drug widely used in veterinary as well as human…”
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Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease by Mezeiova, Eva, Prchal, Lukas, Hrabinova, Martina, Muckova, Lubica, Pulkrabkova, Lenka, Soukup, Ondrej, Misiachna, Anna, Janousek, Jiri, Fibigar, Jakub, Kucera, Tomas, Horak, Martin, Makhaeva, Galina F., Korabecny, Jan

“…The search for novel drugs to address the medical needs of Alzheimer's disease (AD) is an ongoing process relying on the discovery of disease-modifying agents…”
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Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides by Kohoutova, Zuzana, Malinak, David, Andrys, Rudolf, Svobodova, Jana, Psotka, Miroslav, Schmidt, Monika, Prchal, Lukas, Musilek, Kamil

“…The organophosphorus antidotes, so-called oximes, are able to restore the enzymatic function of acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) via…”
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BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS by Prchalova, Eliska, Sukupova, Martina, Malinak, David, Andrys, Rudolf, Sivak, Ladislav, Pekarik, Vladimir, Skarka, Adam, Svobodova, Jana, Prchal, Lukas, Fresser, Lukas, Heger, Zbynek, Musilek, Kamil

“…The BODIPY-labelled oxime reactivator was prepared and used to study its biodistribution into central nervous system. The newly synthesized oxime was found to…”
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The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6- O -desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs by Bures, Jan, Tacheci, Ilja, Kvetina, Jaroslav, Radochova, Vera, Prchal, Lukas, Kohoutova, Darina, Valis, Martin, Novak, Martin, Dolezal, Rafael, Kopacova, Marcela, Rejchrt, Stanislav, Sestak, Vit, Knoblochova, Veronika, Peterova, Eva, Zdarova Karasova, Jana

“…Gastrointestinal side effects of donepezil, including dyspepsia, nausea, vomiting or diarrhea, occur in 20-30% of patients. The pathogenesis of these…”
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Structure-Guided Design of N -Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease by Svobodova, Barbora, Pulkrabkova, Lenka, Panek, Dawid, Misiachna, Anna, Kolcheva, Marharyta, Andrys, Rudolf, Handl, Jiri, Capek, Jan, Nyvltova, Pavlina, Rousar, Tomas, Prchal, Lukas, Hepnarova, Vendula, Hrabinova, Martina, Muckova, Lubica, Tosnerova, Daniela, Karabanovich, Galina, Finger, Vladimir, Soukup, Ondrej, Horak, Martin, Korabecny, Jan

“…Alzheimer's disease (AD) is a complex disease with an unknown etiology. Available treatments, limited to cholinesterase inhibitors and -methyl-d-aspartate…”
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Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer's Disease Treatment by Schmidt, Monika, Benek, Ondrej, Vinklarova, Lucie, Hrabinova, Martina, Zemanova, Lucie, Chribek, Matej, Kralova, Vendula, Hroch, Lukas, Dolezal, Rafael, Lycka, Antonin, Prchal, Lukas, Jun, Daniel, Aitken, Laura, Gunn-Moore, Frank, Kuca, Kamil, Musilek, Kamil

“…Human 17β-hydroxysteroid dehydrogenase type 10 is a multifunctional protein involved in many enzymatic and structural processes within mitochondria. This…”
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Development of versatile and potent monoquaternary reactivators of acetylcholinesterase by Gorecki, Lukas, Hepnarova, Vendula, Karasova, Jana Zdarova, Hrabinova, Martina, Courageux, Charlotte, Dias, José, Kucera, Tomas, Kobrlova, Tereza, Muckova, Lubica, Prchal, Lukas, Malinak, David, Jun, Daniel, Musilek, Kamil, Worek, Franz, Nachon, Florian, Soukup, Ondrej, Korabecny, Jan

“…To date, the only treatments developed for poisoning by organophosphorus compounds, the most toxic chemical weapons of mass destruction, have exhibited limited…”
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Wide-Antimicrobial Spectrum of Picolinium Salts by Salajkova, Sarka, Benkova, Marketa, Marek, Jan, Sleha, Radek, Prchal, Lukas, Malinak, David, Dolezal, Rafael, Sepčić, Kristina, Gunde-Cimerman, Nina, Kuca, Kamil, Soukup, Ondrej

“…Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many…”
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