Search Results - "Prazeres, Verónica F. V."

Structure-Based Design, Synthesis, and Biological Evaluation of Inhibitors of Mycobacterium tuberculosis Type II Dehydroquinase by SáNCHEZ-SIXTO, Cristina, PRAZERES, Verónica F. V., CASTEDO, Luis, LAMB, Heather, HAWKINS, Alastair R., GONZáLEZ-BELLO, Concepción

“…The syntheses by Suzuki cross-coupling of 12 5-aryl analogues of the known inhibitor (1R,3R,4R)-1,3,4-trihydroxycyclohex-5-en-1-carboxylic acid are reported…”
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A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors by Tizón, Lorena, Otero, José M, Prazeres, Verónica F. V, Llamas-Saiz, Antonio L, Fox, Gavin C, van Raaij, Mark J, Lamb, Heather, Hawkins, Alastair R, Ainsa, José A, Castedo, Luis, González-Bello, Concepción

“…The synthesis of high-affinity reversible competitive inhibitors of Mycobacterium tuberculosis type II dehydroquinase, an essential enzyme in Mycobacterium…”
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Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential Residues by Prazeres, Verónica F. V, Tizón, Lorena, Otero, José M, Guardado-Calvo, Pablo, Llamas-Saiz, Antonio L, van Raaij, Mark J, Castedo, Luis, Lamb, Heather, Hawkins, Alastair R, González-Bello, Concepción

“…The shikimic acid pathway is essential to many pathogens but absent in mammals. Enzymes in its pathway are therefore appropriate targets for the development of…”
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Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)‑2-Benzyl-3-dehydroquinic Acids by Lence, Emilio, Tizón, Lorena, Otero, José M, Peón, Antonio, Prazeres, Verónica F. V, Llamas-Saiz, Antonio L, Fox, Gavin C, van Raaij, Mark J, Lamb, Heather, Hawkins, Alastair R, González-Bello, Concepción

“…The structural changes caused by the substitution of the aromatic moiety in (2S)-2-benzyl-3-dehydroquinic acids and its epimers in C2 by electron-withdrawing…”
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Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase: Synthesis, Biological Evaluation, and NMR Studies by Sánchez-Sixto, Cristina, Prazeres, Verónica F. V., Castedo, Luis, Suh, Se Won, Lamb, Heather, Hawkins, Alastair R., Cañada, Francisco Javier, Jiménez-Barbero, Jesús, González-Bello, Concepción

“…Several 3‐heteroaryl analogs of the known dehydroquinase inhibitor (1R,4R,5R)‐1,4,5‐trihydroxy‐2‐cyclohexene‐1‐carboxylic acid (4) were synthesized and tested…”
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Determination of the Bound Conformation of a Competitive Nanomolar Inhibitor of Mycobacterium tuberculosis Type II Dehydroquinase by NMR Spectroscopy by Prazeres, Verónica F. V., Sánchez-Sixto, Cristina, Castedo, Luis, Canales, Ángeles, Cañada, Francisco Javier, Jiménez-Barbero, Jesús, Lamb, Heather, Hawkins, Alastair R., González-Bello, Concepción

“…The synergy between tuberculosis and the AIDS epidemic, along with the surge of multidrug‐resistant isolates of M. tuberculosis, has reaffirmed tuberculosis as…”
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Understanding the Key Factors that Control the Inhibition of Type II Dehydroquinase by (2R)-2-Benzyl-3-dehydroquinic Acids by Peón, Antonio, Otero, José M., Tizón, Lorena, Prazeres, Verónica F. V., Llamas-Saiz, Antonio L., Fox, Gavin C., van Raaij, Mark J., Lamb, Heather, Hawkins, Alastair R., Gago, Federico, Castedo, Luis, González-Bello, Concepción

“…The binding mode of several substrate analogues, (2R)‐2‐benzyl‐3‐dehydroquinic acids 4, which are potent reversible competitive inhibitors of type II…”
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2-Substituted-3-Dehydroquinic Acids as Potent Competitive Inhibitors of Type II Dehydroquinase by Prazeres, Verónica F. V., Castedo, Luis, Lamb, Heather, Hawkins, Alastair R., González-Bello, Concepción

“…Potential antibiotics: The substitution of either the pro‐R or pro‐S hydrogen of the 3‐dehydroquinic acid, the natural substrate of type II dehydroquinase, by…”
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Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase by Prazeres, Verónica F. V., Sánchez-Sixto, Cristina, Castedo, Luis, Lamb, Heather, Hawkins, Alastair R., Riboldi-Tunnicliffe, Alan, Coggins, John R., Lapthorn, Adrian J., González-Bello, Concepción

“…Isomeric nitrophenyl and heterocyclic analogues of the known inhibitor (1S,3R,4R)‐1,3,4‐trihydroxy‐5‐cyclohexene‐1‐carboxylic acid have been synthesized and…”
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Structure-Based Design, Synthesis, and Biological Evaluation of Inhibitors of Mycobacterium t uberculosis Type II Dehydroquinase by Sánchez-Sixto, Cristina, Prazeres, Verónica F. V, Castedo, Luis, Lamb, Heather, Hawkins, Alastair R, González-Bello, Concepción

“…The syntheses by Suzuki cross-coupling of 12 5-aryl analogues of the known inhibitor (1R,3R,4R)-1,3,4-trihydroxycyclohex-5-en-1-carboxylic acid are reported…”
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Stereoselective Synthesis of Novel Cyclic γ-Amino Acids and Triazole Derivatives by Prazeres, Verónica F. V., Castedo, Luis, González-Bello, Concepción

“…Four polyhydroxylated γ‐azido and three γ‐amino acids 1–4 have been synthesized from (–)‐quinic acid. The nitrogen functionality in the reported derivatives…”
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Cover Picture: Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase (ChemMedChem 2/2007) by Prazeres, Verónica F. V., Sánchez-Sixto, Cristina, Castedo, Luis, Lamb, Heather, Hawkins, Alastair R., Riboldi-Tunnicliffe, Alan, Coggins, John R., Lapthorn, Adrian J., González-Bello, Concepción

“…The cover picture shows two representations of two potent competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor dehydroquinase with…”
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