Effect of 2-Hydroxypropyl-β-cyclodextrin on the diffusion behaviour of L-dopa in aqueous solutions

Effect of 2-Hydroxypropyl-β-cyclodextrin on the diffusion behaviour of L-dopa in aqueous solutions

•Ternary diffusion coefficients for aqueous L-dopa and 2-Hydroxypropyl-β-cyclodextrin.•Diffusion of L-dopa driven by 2-Hydroxypropyl-β-cyclodextrin gradients.•Coupled diffusion as indicated by cross-diffusion coefficients. Ternary mutual diffusion coefficients (D11, D22, D12 and D21) measured by the...

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Bibliographic Details
Published in:The Journal of chemical thermodynamics Vol. 97; pp. 122 - 126
Main Authors: Barros, Marisa C.F., Ramos, M. Luísa, Burrows, Hugh D., Esteso, Miguel A., Leaist, Derek G., Prazeres, Patricia A.M., Ribeiro, Ana C.F.
Format: Journal Article
Language:English
Published: Elsevier Ltd 01-06-2016
Subjects:
Aqueous solutions
Complexation
Concentration gradient
Diffusion
Diffusion coefficient
HP-β-cyclodextrin
Joining
Levodopa
NMR spectroscopy
Parkinson disease
Transport
Parkinson disease
Levodopa
Aqueous solutions
HP-β-cyclodextrin
Diffusion coefficient
NMR spectroscopy
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Summary:•Ternary diffusion coefficients for aqueous L-dopa and 2-Hydroxypropyl-β-cyclodextrin.•Diffusion of L-dopa driven by 2-Hydroxypropyl-β-cyclodextrin gradients.•Coupled diffusion as indicated by cross-diffusion coefficients. Ternary mutual diffusion coefficients (D11, D22, D12 and D21) measured by the Taylor dispersion method are reported for aqueous solutions of levodopa (L-dopa) (1) in the presence of 2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) (2) at 25°C and 37°C and concentrations up to 0.005mol·dm−3. The effects of HP-β-CD (HP-β-CD) on the transport of L-dopa are assessed by comparing the binary diffusion coefficient of aqueous L-dopa solutions with the main diffusion coefficient (D11) measured for ternary {L-dopa (1)+HP-β-CD (2)} solutions. 1H NMR spectroscopy suggests no significant complexation between HP-β-CD and L-dopa. However, coupled diffusion of L-dopa and HP-β-CD occurs, as indicated by non-zero values of the cross-diffusion coefficients, D12 and D21. HP-β-CD concentration gradients produce significant co-current coupled flows of L-dopa.
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ISSN:0021-9614
1096-3626
DOI:10.1016/j.jct.2016.01.010