Search Results - "Pravda, Martin"
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Rheological and frictional analysis of viscosupplements towards improved lubrication of human joints
Published in Tribology international (01-08-2021)“…The present paper explores the effect of viscosupplementation on the friction of articular cartilage depending on the rheology of viscosupplements. The…”
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Translational Studies on the Potential of a VEGF Nanoparticle-Loaded Hyaluronic Acid Hydrogel
Published in Pharmaceutics (22-05-2021)“…Heart failure has a five-year mortality rate approaching 50%. Inducing angiogenesis following a myocardial infarction is hypothesized to reduce cardiomyocyte…”
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Development of a Sustained Release Nano-In-Gel Delivery System for the Chemotactic and Angiogenic Growth Factor Stromal-Derived Factor 1α
Published in Pharmaceutics (04-06-2020)“…Stromal-Derived Factor 1α (SDF) is an angiogenic, chemotactic protein with significant potential for applications in a range of clinical areas, including wound…”
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Reductive alkylation of hyaluronic acid for the synthesis of biocompatible hydrogels by click chemistry
Published in Carbohydrate polymers (06-11-2012)“…► Oxidation followed by reductive amination of hyaluronic acid. ► Non toxic catalyst 4-Ac-TEMPO and picoline borane used for the reaction. ► Easy scale-up and…”
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Hyaluronic Acid and Its Derivatives in Coating and Delivery Systems: Applications in Tissue Engineering, Regenerative Medicine and Immunomodulation
Published in Advanced healthcare materials (01-11-2016)“…As an Extracellular Matrix (ECM) component, Hyaluronic acid (HA) plays a multi‐faceted role in cell migration, proliferation and differentiation at micro level…”
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Injectable Hyaluronic Acid Hydrogel Containing Platelet Derivatives for Synovial Fluid Viscosupplementation and Growth Factors Delivery
Published in Macromolecular bioscience (01-04-2023)“…Osteoarthritisis a highly prevalent musculoskeletal disorder characterized by degradation of cartilage and synovial fluid (SF). Platelet derivatives as…”
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Injectable hydroxyphenyl derivative of hyaluronic acid hydrogel modified with RGD as scaffold for spinal cord injury repair
Published in Journal of biomedical materials research. Part A (01-04-2018)“…Hydrogel scaffolds which bridge the lesion, together with stem cell therapy represent a promising approach for spinal cord injury (SCI) repair. In this study,…”
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A composite device for viscosupplementation treatment resistant to degradation by reactive oxygen species and hyaluronidase
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01-12-2022)“…Osteoarthritis (OA) is one of the most common musculoskeletal disorders in the world. OA is often associated with the loss of viscoelastic and tribological…”
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In situ formed aldehyde-modified hyaluronic acid hydrogel with polyelectrolyte complexes of aldehyde-modified chondroitin sulfate and gelatin: An approach for minocycline delivery
Published in Carbohydrate polymers (01-11-2024)“…Polysaccharides like hyaluronan (HA) and chondroitin sulfate (CS) are native of the brain's extracellular matrix crucial for myelination and brain maturation…”
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Enzymatically cross-linked hyaluronic acid hydrogels as in situ forming carriers of platelet-rich plasma: Mechanical properties and bioactivity levels evaluation
Published in Journal of the mechanical behavior of biomedical materials (01-07-2023)“…New studies have shown the great potential of the combination of in situ enzymatically cross-linked hydrogels based on tyramine derivative of hyaluronic acid…”
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On the Dependence of Rheology of Hyaluronic Acid Solutions and Frictional Behavior of Articular Cartilage
Published in Materials (11-06-2020)“…Hyaluronic acid (HA) injections represent one of the most common methods for the treatment of osteoarthritis. However, the clinical results of this method are…”
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Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions
Published in Acta biomaterialia (15-04-2020)“…The incorporation of the RGD peptide (arginine-glycine-aspartate) into biomaterials has been proposed to promote cell adhesion to the matrix, which can…”
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Creating a 3D microenvironment for monocyte cultivation: ECM-mimicking hydrogels based on gelatine and hyaluronic acid derivatives
Published in RSC advances (01-01-2018)“…Macrophages play a critical role in the initial response to foreign materials in the body. As most biomaterial-based implantable devices would be treated as a…”
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The effect of healing phenotype-inducing cytokine formulations within soft hydrogels on encapsulated monocytes and incoming immune cells
Published in RSC advances (10-07-2019)“…The adverse immune responses to implantable biomedical devices is a general problem with important consequences for the functionality of implants…”
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Development of a nanomedicine-loaded hydrogel for sustained delivery of an angiogenic growth factor to the ischaemic myocardium
Published in Drug delivery and translational research (01-04-2020)“…The 5-year mortality rate for heart failure borders on 50%. The main cause is an ischaemic cardiac event where blood supply to the tissue is lost and cell…”
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Chondrogenic differentiation of mesenchymal stem cells in a hydrogel system based on an enzymatically crosslinked tyramine derivative of hyaluronan
Published in Journal of biomedical materials research. Part A (01-10-2014)“…Hyaluronan‐based tissue substitutes are promising materials in cartilage reconstruction surgery. Herein, the chondrogenesis of human mesenchymal stem cells…”
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Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels
Published in Journal of biomaterials applications (01-11-2018)“…Injectable hydrogels that aim to mechanically stabilise the weakened left ventricle wall to restore cardiac function or to deliver stem cells in cardiac…”
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Correlation between structures of chiral polymers and their efficiency for chiral resolution by crystallization
Published in Chirality (New York, N.Y.) (01-10-2009)“…In this work, we describe the correlation between chiral polymer structures, particularly α‐helical and random coil conformations, and their efficiency as…”
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