Search Results - "Pratt, P J"

Recovery of altered neuromuscular junction morphology and muscle function in mdx mice after injury by Pratt, Stephen J. P, Shah, Sameer B, Ward, Christopher W, Kerr, Jaclyn P, Stains, Joseph P, Lovering, Richard M

“…Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease in which weakness, increased susceptibility to muscle injury, and inadequate repair…”
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Augmented reality simulator for CT-guided interventions by Amiras, D., Hurkxkens, T. J., Figueroa, D., Pratt, P. J, Pitrola, B., Watura, C., Rostampour, S., Shimshon, G. J., Hamady, M.

“…Introduction CT-guided interventions are taught using a mentored approach on real patients. It is well established that simulation is a valuable training tool…”
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Microtubule disruption reduces metastasis more effectively than primary tumor growth by Thompson, Keyata N, Ju, Julia A, Ory, Eleanor C, Pratt, Stephen J P, Lee, Rachel M, Mathias, Trevor J, Chang, Katarina T, Lee, Cornell J, Goloubeva, Olga G, Bailey, Patrick C, Chakrabarti, Kristi R, Jewell, Christopher M, Vitolo, Michele I, Martin, Stuart S

“…Clinical cancer imaging focuses on tumor growth rather than metastatic phenotypes. The microtubule-depolymerizing drug, Vinorelbine, reduced the metastatic…”
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SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models by Mázala, Davi A G, Pratt, Stephen J P, Chen, Dapeng, Molkentin, Jeffery D, Lovering, Richard M, Chin, Eva R

“…Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting secondary to repeated muscle damage and inadequate repair. Elevations in…”
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Lipid tethering of breast tumor cells reduces cell aggregation during mammosphere formation by Bhandary, Lekhana, Bailey, Patrick C., Chang, Katarina T., Underwood, Karen F., Lee, Cornell J., Whipple, Rebecca A., Jewell, Christopher M., Ory, Eleanor, Thompson, Keyata N., Ju, Julia A., Mathias, Trevor M., Pratt, Stephen J. P., Vitolo, Michele I., Martin, Stuart S.

“…Mammosphere assays are widely used in vitro to identify prospective cancer-initiating stem cells that can propagate clonally to form spheres in free-floating…”
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Quantitative analysis of technological innovation in minimally invasive surgery by Hughes-Hallett, A., Mayer, E. K., Pratt, P. J., Vale, J. A., Darzi, A. W.

“…Background In the past 30 years surgical practice has changed considerably owing to the advent of minimally invasive surgery (MIS). This paper investigates the…”
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Pre- and postsynaptic changes in the neuromuscular junction in dystrophic mice by Pratt, Stephen J P, Valencia, Ana P, Le, Gloribel K, Shah, Sameer B, Lovering, Richard M

“…Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease in which weakness, increased susceptibility to muscle injury, and inadequate repair…”
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Critical Role of Intracellular RyR1 Calcium Release Channels in Skeletal Muscle Function and Disease by Hernández-Ochoa, Erick O, Pratt, Stephen J P, Lovering, Richard M, Schneider, Martin F

“…The skeletal muscle Ca(2+) release channel, also known as ryanodine receptor type 1 (RyR1), is the largest ion channel protein known and is crucial for…”
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Effects of myofiber isolation technique on sarcolemma biomechanics by Garcia-Pelagio, Karla P, Pratt, Stephen JP, Lovering, Richard M

“…Isolated myofibers are commonly used to understand the function of skeletal muscle . This can involve single isolated myofibers obtained from dissection or…”
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The Mechanical Microenvironment in Breast Cancer by Pratt, Stephen J.P., Lee, Rachel M., Martin, Stuart S.

“…Mechanotransduction is the interpretation of physical cues by cells through mechanosensation mechanisms that elegantly translate mechanical stimuli into…”
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Diffusion Tensor MRI to Assess Damage in Healthy and Dystrophic Skeletal Muscle after Lengthening Contractions by McMillan, Alan B., Shi, Da, Pratt, Stephen J. P., Lovering, Richard M.

“…The purpose of this study was to determine if variables calculated from diffusion tensor imaging (DTI) would serve as a reliable marker of damage after a…”
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A high throughput cell stretch device for investigating mechanobiology in vitro by Pratt, Stephen J. P., Plunkett, Christopher M., Kuzu, Guray, Trinh, Ton, Barbara, Joshua, Choconta, Paula, Quackenbush, Doug, Huynh, Truc, Smith, Anders, Barnes, S. Whitney, New, Joel, Pierce, James, Walker, John R., Mainquist, James, King, Frederick J., Elliott, Jimmy, Hammack, Scott, Decker, Rebekah S.

“…Mechanobiology is a rapidly advancing field, with growing evidence that mechanical signaling plays key roles in health and disease. To accelerate…”
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Effects of in vivo injury on the neuromuscular junction in healthy and dystrophic muscles by Pratt, Stephen J.P., Shah, Sameer B., Ward, Christopher W., Inacio, Mario P., Stains, Joseph P., Lovering, Richard M.

“…Key points •  Strength loss induced by lengthening contractions is typically attributed to damaged force‐bearing structures within skeletal muscle. Muscle…”
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Elevation of Cytoplasmic Calcium Suppresses Microtentacle Formation and Function in Breast Tumor Cells by Chang, Katarina T, Thompson, Keyata N, Pratt, Stephen J P, Ju, Julia A, Lee, Rachel M, Mathias, Trevor J, Mull, Makenzy L, Annis, David A, Ory, Eleanor C, Stemberger, Megan B, Vitolo, Michele I, Martin, Stuart S

“…Cytoskeletal remodeling in circulating tumor cells (CTCs) facilitates metastatic spread. Previous oncology studies examine sustained aberrant calcium (Ca )…”
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The Activation of Protein Kinase A by the Calcium-Binding Protein S100A1 Is Independent of Cyclic AMP by Melville, Zephan, Hernández-Ochoa, Erick O, Pratt, Stephen J. P, Liu, Yewei, Pierce, Adam D, Wilder, Paul T, Adipietro, Kaylin A, Breysse, Daniel H, Varney, Kristen M, Schneider, Martin F, Weber, David J

“…Biochemical and structural studies demonstrate that S100A1 is involved in a Ca2+-dependent interaction with the type 2α and type 2β regulatory subunits of…”
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Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle by Kombairaju, Ponvijay, Kerr, Jaclyn P, Roche, Joseph A, Pratt, Stephen J P, Lovering, Richard M, Sussan, Thomas E, Kim, Jung-Hyun, Shi, Guoli, Biswal, Shyam, Ward, Christopher W

“…Oxidative stress is a critical disease modifier in the muscular dystrophies. Recently, we discovered a pathway by which mechanical stretch activates NADPH…”
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Early metabolic changes measured by 1H MRS in healthy and dystrophic muscle after injury by Xu, Su, Pratt, Stephen J P, Spangenburg, Espen E, Lovering, Richard M

“…Skeletal muscle injury is often assessed by clinical findings (history, pain, tenderness, strength loss), by imaging, or by invasive techniques. The purpose of…”
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Disruption of action potential and calcium signaling properties in malformed myofibers from dystrophin‐deficient mice by Hernández‐Ochoa, Erick O., Pratt, Stephen J. P., Garcia‐Pelagio, Karla P., Schneider, Martin F., Lovering, Richard M.

“…Duchenne muscular dystrophy (DMD), the most common and severe muscular dystrophy, is caused by the absence of dystrophin. Muscle weakness and fragility (i.e.,…”
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The heritabilities, phenotypic correlations, and genetic correlations of lean color and palatability measures from longissimus muscle in beef cattle by Pratt, P J, Moser, D W, Thompson, L D, Jackson, S P, Johnson, B J, Garmyn, A J, Miller, M F

“…Data from a study conducted over 5 yr were analyzed to determine heritability estimates of LM lean color, as measured by subjective scoring and Hunter…”
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Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca2+ signals that are inhibited by oncogenic KRas by Pratt, Stephen J. P., Lee, Rachel M., Chang, Katarina T., Hernández-Ochoa, Erick O., Annis, David A., Ory, Eleanor C., Thompson, Keyata N., Bailey, Patrick C., Mathias, Trevor J., Ju, Julia A., Vitolo, Michele I., Schneider, Martin F., Stains, Joseph P., Ward, Christopher W., Martin, Stuart S.

“…Changes in the mechanical microenvironment and mechanical signals are observed during tumor progression, malignant transformation, and metastasis. In this…”
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