Search Results - "Pratt, Hillary G."

Synthesis, Characterization, and In Vivo Cytokinome Profile of IL-12-Loaded PLGA Nanospheres by Lacinski, Ryan A., Markel, Justin E., Noore, Jabeen, Pratt, Hillary G., Lindsey, Brock A.

“…We report the successful encapsulation and elution of recombinant murine IL-12 (rmIL-12) from poly(lactide-co-glycolic) acid (PLGA) nanospheres (IL-12-NS)…”
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Analysis of single nuclear chromatin accessibility reveals unique myeloid populations in human pancreatic ductal adenocarcinoma by Pratt, Hillary G., Ma, Li, Dziadowicz, Sebastian A., Ott, Sascha, Whalley, Thomas, Szomolay, Barbara, Eubank, Timothy D., Hu, Gangqing, Boone, Brian A.

“…Background A better understanding of the pancreatic ductal adenocarcinoma (PDAC) immune microenvironment is critical to developing new treatments and improving…”
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Optimizing the synthesis of interleukin‐12‐loaded PLGA nanospheres (rmIL‐12ns) via ultrasonication for treatment of metastatic osteosarcoma by Lacinski, Ryan A., Markel, Justin E., Pratt, Hillary G., Reinbeau, Ryan M., Stewart, Amanda, Santiago, Stell P., Lindsey, Brock A.

“…Clinical trials exploring bolus intravenous delivery of interleukin‐12 (IL‐12) for treatment of solid tumors ultimately failed due to lack of clinical response…”
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Pancreatectomy Induces Cancer-Promoting Neutrophil Extracellular Traps by Ivey, Abby D., Pratt, Hillary G., Niemann, Britney, Ranson, Kristen, Puleo, Amanda, Fagan, B. Matthew, Rao, Pavan, Landreth, Kaitlyn M., Liu, Tracy W., Boone, Brian A.

“…Background Neutrophil extracellular traps (NETs) occur when neutrophil chromatin is decondensed and extruded into the extracellular space in a web-like…”
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Macrophage and Neutrophil Interactions in the Pancreatic Tumor Microenvironment Drive the Pathogenesis of Pancreatic Cancer by Pratt, Hillary G, Steinberger, Kayla J, Mihalik, Nicole E, Ott, Sascha, Whalley, Thomas, Szomolay, Barbara, Boone, Brian A, Eubank, Timothy D

“…Despite modest improvements in survival in recent years, pancreatic adenocarcinoma remains a deadly disease with a 5-year survival rate of only 9%. These poor…”
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ASO Visual Abstract: Pancreatectomy Induces Cancer-Promoting Neutrophil Extracellular Traps by Ivey, Abby D., Pratt, Hillary G., Niemann, Britney, Ranson, Kristen, Puleo, Amanda, Fagan, B. Matthew, Rao, Pavan, Landreth, Kaitlyn M., Liu, Tracy W., Boone, Brian A.

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Applying Osteosarcoma Immunology to Understand Disease Progression and Assess Immunotherapeutic Response by Pratt, Hillary G, Justin, E Markel, Lindsey, Brock A

“…Osteosarcoma, the most common malignant bone tumor in children and adolescents, remains a complicated disease to treat; no new treatments have been developed…”
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