Search Results - "Pratt, Evan P.S."

The ERG1a potassium channel increases basal intracellular calcium concentration and calpain activity in skeletal muscle cells by Whitmore, Clayton, Pratt, Evan P S, Anderson, Luke, Bradley, Kevin, Latour, Sawyer M, Hashmi, Mariam N, Urazaev, Albert K, Weilbaecher, Rod, Davie, Judith K, Wang, Wen-Horng, Hockerman, Gregory H, Pond, Amber L

“…Skeletal muscle atrophy is the net loss of muscle mass that results from an imbalance in protein synthesis and protein degradation. It occurs in response to…”
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Bimolecular Fluorescence Complementation (BiFC) Analysis of Protein-Protein Interactions and Assessment of Subcellular Localization in Live Cells by Pratt, Evan P S, Owens, Jake L, Hockerman, Gregory H, Hu, Chang-Deng

“…Bimolecular fluorescence complementation (BiFC) is a fluorescence imaging technique used to visualize protein-protein interactions (PPIs) in live cells and…”
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Systematic Comparison of Vesicular Targeting Signals Leads to the Development of Genetically Encoded Vesicular Fluorescent Zn2+ and pH Sensors by Pratt, Evan P.S, Anson, Kelsie J, Tapper, Justin K, Simpson, David M, Palmer, Amy E

“…Genetically encoded fluorescent sensors have been widely used to illuminate secretory vesicle dynamics and the vesicular lumen, including Zn2+ and pH, in…”
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Potentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 cells: comparison of tolbutamide and gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx by Jarrard, Rachel E, Wang, Yuchen, Salyer, Amy E, Pratt, Evan P S, Soderling, Ian M, Guerra, Marcy L, Lange, Allison M, Broderick, Hilary J, Hockerman, Gregory H

“…Tolbutamide and gliclazide block the K(ATP) channel K(ir)6.2/Sur1, causing membrane depolarization and stimulating insulin secretion in pancreatic beta cells…”
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Uncoupling of Cav1.2 From Ca2+-Induced Ca2+ Release and SK Channel Regulation in Pancreatic β-Cells by Wang, Yuchen, Jarrard, Rachel E, Pratt, Evan P.S, Guerra, Marcy L, Salyer, Amy E, Lange, Allison M, Soderling, Ian M, Hockerman, Gregory H

“…We investigated the role of Cav1.2 in pancreatic β-cell function by expressing a Cav1.2 II-III loop/green fluorescent protein fusion in INS-1 cells…”
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Tools and techniques for illuminating the cell biology of zinc by Pratt, Evan P.S., Damon, Leah J., Anson, Kelsie J., Palmer, Amy E.

“…Zinc (Zn2+) is an essential micronutrient that is required for a wide variety of cellular processes. Tools and methods have been instrumental in revealing the…”
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Regulation of cAMP accumulation and activity by distinct phosphodiesterase subtypes in INS-1 cells and human pancreatic β-cells by Pratt, Evan P S, Harvey, Kyle E, Salyer, Amy E, Hockerman, Gregory H

“…Pancreatic β-cells express multiple phosphodiesterase (PDE) subtypes, but the specific roles for each in β-cell function, particularly in humans, is not clear…”
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RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1 by Harvey, Kyle E., LaVigne, Emily K., Dar, Mohd Saleem, Salyer, Amy E., Pratt, Evan P. S., Sample, Paxton A., Aryal, Uma K., Gowher, Humaira, Hockerman, Gregory H.

“…The role of ER Ca 2+ release via ryanodine receptors (RyR) in pancreatic β-cell function is not well defined. Deletion of RyR2 from the rat insulinoma INS-1…”
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Ca2+ influx through L-type Ca2+ channels and Ca2+-induced Ca2+ release regulate cAMP accumulation and Epac1-dependent ERK 1/2 activation in INS-1 cells by Pratt, Evan P.S., Salyer, Amy E., Guerra, Marcy L., Hockerman, Gregory H.

“…We previously reported that INS-1 cells expressing the intracellular II-III loop of the L-type Ca2+ channel Cav1.2 (Cav1.2/II-III cells) are deficient in…”
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Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor by Conley, Jason M, Brand, Cameron S, Bogard, Amy S, Pratt, Evan P S, Xu, Ruqiang, Hockerman, Gregory H, Ostrom, Rennolds S, Dessauer, Carmen W, Watts, Val J

“…Adenylyl cyclase (AC) isoforms are implicated in several physiologic processes and disease states, but advancements in the therapeutic targeting of AC isoforms…”
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Uncoupling of Ca v 1.2 From Ca 2+ -Induced Ca 2+ Release and SK Channel Regulation in Pancreatic β-Cells by Wang, Yuchen, Jarrard, Rachel E., Pratt, Evan P.S., Guerra, Marcy L., Salyer, Amy E., Lange, Allison M., Soderling, Ian M., Hockerman, Gregory H.

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Systematic Comparison of Vesicular Targeting Signals Leads to the Development of Genetically Encoded Vesicular Fluorescent Zn 2+ and pH Sensors by Pratt, Evan P S, Anson, Kelsie J, Tapper, Justin K, Simpson, David M, Palmer, Amy E

“…Genetically encoded fluorescent sensors have been widely used to illuminate secretory vesicle dynamics and the vesicular lumen, including Zn and pH, in living…”
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Uncoupling of Cav1.2 from Ca(2+)-induced Ca(2+) release and SK channel regulation in pancreatic β-cells by Wang, Yuchen, Jarrard, Rachel E, Pratt, Evan P S, Guerra, Marcy L, Salyer, Amy E, Lange, Allison M, Soderling, Ian M, Hockerman, Gregory H

“…We investigated the role of Cav1.2 in pancreatic β-cell function by expressing a Cav1.2 II-III loop/green fluorescent protein fusion in INS-1 cells…”
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Comparative proteomics of chloroplasts envelopes from bundle sheath and mesophyll chloroplasts reveals novel membrane proteins with a possible role in c4-related metabolite fluxes and development by Manandhar-Shrestha, K, Tamot, B, Pratt, E P S, Saitie, S, Bräutigam, A, Weber, A P M, Hoffmann-Benning, Susanne

“…As the world population grows, our need for food increases drastically. Limited amounts of arable land lead to a competition between food and fuel crops, while…”
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