Search Results - "Pratt, Ashley J"

The RNA-induced Silencing Complex: A Versatile Gene-silencing Machine by Pratt, Ashley J., MacRae, Ian J.

“…RNA interference is a powerful mechanism of gene silencing that underlies many aspects of eukaryotic biology. On the molecular level, RNA interference is…”
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Plant UVR8 Photoreceptor Senses UV-B by Tryptophan-Mediated Disruption of Cross-Dimer Salt Bridges by Christie, John M., Arvai, Andrew S., Baxter, Katherine J., Heilmann, Monika, Pratt, Ashley J., O'Hara, Andrew, Kelly, Sharon M., Hothorn, Michael, Smith, Brian O., Hitomi, Kenichi, Jenkins, Gareth I., Getzoff, Elizabeth D.

“…The recently identified plant photoreceptor UVR8 (UV RESISTANCE LOCUS 8) triggers regulatory changes in gene expression in response to ultraviolet-B (UV-B)…”
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Structural Tuning of the Fluorescent Protein iLOV for Improved Photostability by Christie, John M., Hitomi, Kenichi, Arvai, Andrew S., Hartfield, Kimberly A., Mettlen, Marcel, Pratt, Ashley J., Tainer, John A., Getzoff, Elizabeth D.

“…Fluorescent proteins derived from light, oxygen, or voltage (LOV) domains offer advantages over green fluorescent protein (GFP) from their small size and…”
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Copper-Based Pulsed Dipolar ESR Spectroscopy as a Probe of Protein Conformation Linked to Disease States by Merz, Gregory E., Borbat, Peter P., Pratt, Ashley J., Getzoff, Elizabeth D., Freed, Jack H., Crane, Brian R.

“…We demonstrate the ability of pulsed dipolar electron spin resonance (ESR) spectroscopy (PDS) to report on the conformation of Cu-Zn superoxide dismutase…”
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Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes by Pratt, Ashley J., Shin, David S., Merz, Gregory E., Rambo, Robert P., Lancaster, W. Andrew, Dyer, Kevin N., Borbat, Peter P., Poole, Farris L., Adams, Michael W. W., Freed, Jack H., Crane, Brian R., Tainer, John A., Getzoff, Elizabeth D.

“…Protein framework alterations in heritable Cu, Zn superoxide dismutase (SOD) mutants cause misassembly and aggregation in cells affected by the motor neuron…”
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Preparation and characterization of the extracellular domain of human Sid-1 by Pratt, Ashley J, Rambo, Robert P, Lau, Pick-Wei, MacRae, Ian J

“…In C. elegans, the cell surface protein Sid-1 imports extracellular dsRNA into the cytosol of most non-neuronal cells, enabling systemic spread of RNA…”
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Archaeal Genome Guardians Give Insights into Eukaryotic DNA Replication and Damage Response Proteins by Shin, David S., Tainer, John A., Pratt, Ashley J.

“…As the third domain of life, archaea, like the eukarya and bacteria, must have robust DNA replication and repair complexes to ensure genome fidelity. Archaea…”
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Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus by Pratt, Ashley J, DiDonato, Michael, Shin, David S, Cabelli, Diane E, Bruns, Cami K, Belzer, Carol A, Gorringe, Andrew R, Langford, Paul R, Tabatabai, Louisa B, Kroll, J Simon, Tainer, John A, Getzoff, Elizabeth D

“…Bacterial pathogens Neisseria meningitidis and Brucella abortus pose threats to human and animal health worldwide, causing meningococcal disease and…”
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Single-pot enzymatic synthesis of Dicer-substrate siRNAs by Guiley, Keelan Z., Pratt, Ashley J., MacRae, Ian J.

“…We describe an inexpensive and efficient method for generating functional pools of Dicer-substrate small interfering RNAs (siRNAs) in a single reaction tube…”
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Amyotrophic lateral sclerosis: update and new developments by Pratt, Ashley J, Getzoff, Elizabeth D, Perry, J Jefferson P

“…Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease. It is typically characterized by adult-onset degeneration of the upper and…”
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Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus by Pratt, Ashley J., DiDonato, Michael, Shin, David S., Cabelli, Diane E., Bruns, Cami K., Belzer, Carol A., Gorringe, Andrew R., Langford, Paul R., Tabatabai, Louisa B., Kroll, J. Simon, Tainer, John A., Getzoff, Elizabeth D., Stock, A. M.

“…ABSTRACT Bacterial pathogens<named-content content-type='genus-species'>Neisseria meningitidis</named-content>and<named-content…”
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Mechanistic Insights into the Roles and Consequences of Deliberate and Aberrant Oligomerization by Pratt, Ashley J

“…Oligomeric proteins are abundant in nature, and their aggregation state can fundamentally dictate both cellular homeostasis and pathogenesis. The stability of…”
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