Search Results - "Pratt, A."

Is a Cambrian Explosion Coming for Robotics? by Pratt, Gill A

“…About half a billion years ago, life on earth experienced a short period of very rapid diversification called the “Cambrian Explosion.” Many theories have been…”
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Radical Substitution Provides a Unique Route to Disulfides by Wu, Zijun, Pratt, Derek A

“…Radical substitution on tetrasulfides is demonstrated to be a highly effective means to prepare unsymmetric disulfides. Alkyl and aryl radicals generated…”
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Advances in Radical-Trapping Antioxidant Chemistry in the 21st Century: A Kinetics and Mechanisms Perspective by Ingold, Keith U, Pratt, Derek A

“…Ingold and Pratt examine advances in radical-trapping antioxidant chemistry in the 21st century with regard to a kinetics and mechanisms…”
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Ferroptosis Inhibition: Mechanisms and Opportunities by Angeli, Jose Pedro Friedmann, Shah, Ron, Pratt, Derek A, Conrad, Marcus

“…The past decade has yielded tremendous insights into how cells die. This has come with our understanding that several distinct forms of cell death are…”
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Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers by Soula, Mariluz, Weber, Ross A., Zilka, Omkar, Alwaseem, Hanan, La, Konnor, Yen, Frederick, Molina, Henrik, Garcia-Bermudez, Javier, Pratt, Derek A., Birsoy, Kıvanç

“…Cancer cells rewire their metabolism and rely on endogenous antioxidants to mitigate lethal oxidative damage to lipids. However, the metabolic processes that…”
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The Potency of Diarylamine Radical-Trapping Antioxidants as Inhibitors of Ferroptosis Underscores the Role of Autoxidation in the Mechanism of Cell Death by Shah, Ron, Margison, Kaitlyn, Pratt, Derek A

“…Two aromatic amines (ferrostatin-1 and liproxstatin-1) were recently identified from high-throughput screening efforts to uncover potent inhibitors of…”
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Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis by Shah, Ron, Shchepinov, Mikhail S, Pratt, Derek A

“…Lipoxygenases (LOXs) have been implicated as central players in ferroptosis, a recently characterized cell death modality associated with the accumulation of…”
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Recent Insights on Hydrogen Atom Transfer in the Inhibition of Hydrocarbon Autoxidation by Poon, Jia-Fei, Pratt, Derek A

“…Conspectus Autoxidation, the free radical chain reaction that nominally inserts O2 into hydrocarbons to give peroxides, is primarily responsible for the…”
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A non-canonical vitamin K cycle is a potent ferroptosis suppressor by Mishima, Eikan, Ito, Junya, Wu, Zijun, Nakamura, Toshitaka, Wahida, Adam, Doll, Sebastian, Tonnus, Wulf, Nepachalovich, Palina, Eggenhofer, Elke, Aldrovandi, Maceler, Henkelmann, Bernhard, Yamada, Ken-ichi, Wanninger, Jonas, Zilka, Omkar, Sato, Emiko, Feederle, Regina, Hass, Daniela, Maida, Adriano, Mourão, André Santos Dias, Linkermann, Andreas, Geissler, Edward K., Nakagawa, Kiyotaka, Abe, Takaaki, Fedorova, Maria, Proneth, Bettina, Pratt, Derek A., Conrad, Marcus

“…Ferroptosis, a non-apoptotic form of cell death marked by iron-dependent lipid peroxidation 1 , has a key role in organ injury, degenerative disease and…”
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Lipid Peroxidation: Kinetics, Mechanisms, and Products by Zielinski, Zosia A. M, Pratt, Derek A

“…Recent advances in our understanding of lipid peroxidation, a degenerative process that is believed to play a key role in the pathogenesis of many diseases,…”
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Electrically controlled water permeation through graphene oxide membranes by Zhou, K.-G., Vasu, K. S., Cherian, C. T., Neek-Amal, M., Zhang, J. C., Ghorbanfekr-Kalashami, H., Huang, K., Marshall, O. P., Kravets, V. G., Abraham, J., Su, Y., Grigorenko, A. N., Pratt, A., Geim, A. K., Peeters, F. M., Novoselov, K. S., Nair, R. R.

“…Controlled transport of water molecules through membranes and capillaries is important in areas as diverse as water purification and healthcare technologies 1…”
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Methods for determining the efficacy of radical-trapping antioxidants by Li, Bo, Pratt, Derek A.

“…Hydrocarbon autoxidation is the free radical chain reaction primarily responsible for the oxidative degradation of organic materials, including those that make…”
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Ultrathin graphene-based membrane with precise molecular sieving and ultrafast solvent permeation by Yang, Q., Su, Y., Chi, C., Cherian, C. T., Huang, K., Kravets, V. G., Wang, F. C., Zhang, J. C., Pratt, A., Grigorenko, A. N., Guinea, F., Geim, A. K., Nair, R. R.

“…Highly laminar graphene oxide flakes (10 to 20 μm in diameter) are fabricated. Reducing flake thickness to 10 nm enables water and organic solvent permeation,…”
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Marine and terrestrial influences on ice nucleating particles during continuous springtime measurements in an Arctic oilfield location by Creamean, Jessie M, Kirpes, Rachel M, Pratt, Kerri A, Spada, Nicholas J, Maahn, Maximilian, de Boer, Gijs, Schnell, Russell C, China, Swarup

“…Aerosols that serve as ice nucleating particles (INPs) have the potential to modulate cloud microphysical properties and can therefore impact cloud radiative…”
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Maximizing the Reactivity of Phenolic and Aminic Radical-Trapping Antioxidants: Just Add Nitrogen by Valgimigli, Luca, Pratt, Derek A

“…Hydrocarbon autoxidation, the archetype free radical chain reaction, challenges the longevity of both living organisms and petroleum-derived products. The most…”
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Free Radical Oxidation of Polyunsaturated Lipids: New Mechanistic Insights and the Development of Peroxyl Radical Clocks by Pratt, Derek A, Tallman, Keri A, Porter, Ned A

“…The peroxidation of lipids in biological membranes has been implicated in both the onset and development of most degenerative diseases. The primary products of…”
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pH-dependent production of molecular chlorine, bromine, and iodine from frozen saline surfaces by Halfacre, John W, Shepson, Paul B, Pratt, Kerri A

“…The mechanisms of molecular halogen production from frozen saline surfaces remain incompletely understood, limiting our ability to predict atmospheric…”
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Mechanism of Electrochemical Generation and Decomposition of Phthalimide-N‑oxyl by Yang, Cheng, Farmer, Luke A, Pratt, Derek A, Maldonado, Stephen, Stephenson, Corey R. J

“…Phthalimide N-oxyl (PINO) is a potent hydrogen atom transfer (HAT) catalyst that can be generated electrochemically from N-hydroxyphthalimide (NHPI). However,…”
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Excess mortality due to depression and anxiety in the United States: results from a nationally representative survey by Pratt, Laura A., Ph.D, Druss, Benjamin G., M.D., M.P.H, Manderscheid, Ronald W., Ph.D, Walker, Elizabeth Reisinger, Ph.D., M.P.H., M.A.T

“…Abstract Objectives We compared the mortality of persons with and without anxiety and depression in a nationally representative survey and examined the role of…”
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On the Mechanism of Cytoprotection by Ferrostatin‑1 and Liproxstatin‑1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death by Zilka, Omkar, Shah, Ron, Li, Bo, Friedmann Angeli, José Pedro, Griesser, Markus, Conrad, Marcus, Pratt, Derek A

“…Ferroptosis is a form of regulated necrosis associated with the iron-dependent accumulation of lipid hydroperoxides that may play a key role in the…”
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