Zebrafish as a model to study inflammation: A tool for drug discovery

This study aims to demonstrate the applicability and importance of zebrafish (Danio rerio) model to study acute and chronic inflammatory responses induced by different stimuli: carrageenan phlogogen (nonimmune); acute infection by bacteria (immune); foreign body reaction (chronic inflammation by rou...

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Bibliographic Details
Published in:	Biomedicine & pharmacotherapy Vol. 144; p. 112310
Main Authors:	Belo, Marco A.A., Oliveira, Melque F., Oliveira, Susana L., Aracati, Mayumi F., Rodrigues, Letícia F., Costa, Camila C., Conde, Gabriel, Gomes, Juliana M.M., Prata, Mariana N.L., Barra, Ayslan, Valverde, Thalita M., de Melo, Daniela C., Eto, Silas F., Fernandes, Dayanne C., Romero, Marina G.M.C., Corrêa Júnior, José D., Silva, Juliana O., Barros, Andre L.B., Perez, Andrea C., Charlie-Silva, Ives
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-12-2021 Elsevier
Subjects:	Acute and chronic inflammation Animals Anti-Inflammatory Agents - pharmacology Disease Models, Animal Drug Discovery Edema - etiology Edema - genetics Edema - metabolism Edema - prevention & control Female Foreign body reaction Gene Expression Regulation Inflammation - etiology Inflammation - genetics Inflammation - metabolism Inflammation - prevention & control Inflammatory reaction Innate Immunity Male Signal Transduction Teleost fish Time Factors Xenotransplantation Zebrafish Acute and chronic inflammation Foreign body reaction Inflammatory reaction Teleost fish Xenotransplantation Innate Immunity
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Summary:	This study aims to demonstrate the applicability and importance of zebrafish (Danio rerio) model to study acute and chronic inflammatory responses induced by different stimuli: carrageenan phlogogen (nonimmune); acute infection by bacteria (immune); foreign body reaction (chronic inflammation by round glass coverslip implantation); reaction induced by xenotransplantation. In addition to the advantages of presenting low breeding cost, high prolificity, transparent embryos, high number of individuals belonging to the same spawning and high genetic similarity that favor translational responses to vertebrate organisms like humans, zebrafish proved to be an excellent tool, allowing the evaluation of edema formation, accumulation of inflammatory cells in the exudate, mediators, signaling pathways, gene expression and production of specific proteins. Our studies demonstrated the versatility of fish models to investigate the inflammatory response and its pathophysiology, essential for the successful development of studies to discover innovative pharmacological strategies.
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2021.112310