Search Results - "Prat‐Gay, Gonzalo"

The structure of the extended E2 DNA‐binding domain of the bovine papillomavirus‐1 by Leroy, Ludmila, Barbosa, João Alexandre Ribeiro Gonçalves, Prat‐Gay, Gonzalo, Polikarpov, Igor, Pinheiro, Carlos Basílio

“…Bovine papillomavirus proteins were extensively studied as a prototype for the human papillomavirus. Here, the crystal structure of the extended E2 DNA‐binding…”
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Deconstructing virus condensation by Lopez, Nora, Camporeale, Gabriela, Salgueiro, Mariano, Borkosky, Silvia Susana, Visentín, Araceli, Peralta-Martinez, Ramon, Loureiro, María Eugenia, de Prat-Gay, Gonzalo

“…Viruses have evolved precise mechanisms for using the cellular physiological pathways for their perpetuation. These virus-driven biochemical events must be…”
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Sequence evolution of the intrinsically disordered and globular domains of a model viral oncoprotein by Chemes, Lucía B, Glavina, Juliana, Alonso, Leonardo G, Marino-Buslje, Cristina, de Prat-Gay, Gonzalo, Sánchez, Ignacio E

“…In the present work, we have used the papillomavirus E7 oncoprotein to pursue structure-function and evolutionary studies that take into account intrinsic…”
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Mechanism of Tetramer Dissociation, Unfolding, and Oligomer Assembly of Pneumovirus M2‑1 Transcription Antiterminators by Esperante, Sebastián A, Alvarez-Paggi, Damián, Salgueiro, Mariano, Prat Gay, Gonzalo de

“…Among Mononegavirales, the Pneumovirus family stands out by its RNA polymerase processivity that relies on a transcription antiterminator, the M2-1 protein,…”
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Transition State for Protein: DNA Recognition by Ferreiro, Diego U., Sánchez, Ignacio E., de Prat Gay, Gonzalo

“…We describe the formation of protein-DNA contacts in the two-state route for DNA sequence recognition by a transcriptional regulator. Surprisingly, direct…”
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Conformational Isomerization Involving Conserved Proline Residues Modulates Oligomerization of the NS1 Interferon Response Inhibitor from the Syncytial Respiratory Virus by Conci, Julieta, Alvarez-Paggi, Damian, de Oliveira, Guilherme A. P, Pagani, Talita D, Esperante, Sebastian A, Borkosky, Silvina S, Aran, Martin, Alonso, Leonardo G, Mohana-Borges, Ronaldo, Prat-Gay, Gonzalo de

“…Interferon response suppression by the respiratory syncytial virus relies on two unique nonstructural proteins, NS1 and NS2, that interact with cellular…”
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Convergent evolution and mimicry of protein linear motifs in host–pathogen interactions by Chemes, Lucía Beatriz, de Prat-Gay, Gonzalo, Sánchez, Ignacio Enrique

“…•Pathogen linear motif mimics resemble, but are not exact copies of host motifs.•Distinct motif repertoires determine functional output of pathogen…”
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Intrinsic Disorder to Order Transitions in the Scaffold Phosphoprotein P from the Respiratory Syncytial Virus RNA Polymerase Complex by Noval, María G, Esperante, Sebastian A, Molina, Ivana G, Chemes, Lucía B, Prat-Gay, Gonzalo de

“…Intrinsic disorder is at the center of biochemical regulation and is particularly overrepresented among the often multifunctional viral proteins. Replication…”
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Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein. Structural modularity, intrinsic disorder and phosphorylation of human papillomavirus E7 by Chemes, Lucía B, Sánchez, Ignacio E, Smal, Clara, de Prat-Gay, Gonzalo

“…DNA tumor viruses ensure genome amplification by hijacking the cellular replication machinery and forcing infected cells to enter the S phase. The…”
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Assembly of the Tripartite and RNA Condensates of the Respiratory Syncytial Virus Factory Proteins In Vitro: Role of the Transcription Antiterminator M2-1 by Visentin, Araceli, Demitroff, Nicolás, Salgueiro, Mariano, Borkosky, Silvia Susana, Uversky, Vladimir N., Camporeale, Gabriela, de Prat-Gay, Gonzalo

“…A wide variety of viruses replicate in liquid-like viral factories. Non-segmented negative stranded RNA viruses share a nucleoprotein (N) and a phosphoprotein…”
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Regulation of Tacaribe Mammarenavirus Translation: Positive 5' and Negative 3' Elements and Role of Key Cellular Factors by Foscaldi, Sabrina, D'Antuono, Alejandra, Noval, María Gabriela, de Prat Gay, Gonzalo, Scolaro, Luis, Lopez, Nora

“…Mammarenaviruses are enveloped viruses with a bisegmented negative-stranded RNA genome that encodes the nucleocapsid protein (NP), the envelope glycoprotein…”
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Cysteine-Rich Positions Outside the Structural Zinc Motif of Human Papillomavirus E7 Provide Conformational Modulation and Suggest Functional Redox Roles by Chemes, Lucía B, Camporeale, Gabriela, Sánchez, Ignacio E, de Prat-Gay, Gonzalo, Alonso, Leonardo G

“…The E7 protein from high-risk human papillomavirus is essential for cell transformation in cervical, oropharyngeal, and other HPV-related cancers, mainly…”
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The non-structural NS1 protein unique to respiratory syncytial virus: a two-state folding monomer in quasi-equilibrium with a stable spherical oligomer by Pretel, Esteban, Camporeale, Gabriela, de Prat-Gay, Gonzalo

“…Human respiratory syncytial virus (hRSV) is a major infectious agent that cause pediatric respiratory disease worldwide. Considered one of the main virulence…”
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Conformational Heterogeneity Determined by Folding and Oligomer Assembly Routes of the Interferon Response Inhibitor NS1 Protein, Unique to Human Respiratory Syncytial Virus by Pretel, Esteban, Sánchez, Ignacio E, Fassolari, Marisol, Chemes, Lucía B, de Prat-Gay, Gonzalo

“…The nonstructural NS1 protein is an essential virulence factor of the human respiratory syncytial virus, with a predominant role in the inhibition of the host…”
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Nuclease Activity of the Junín Virus Nucleoprotein C-Terminal Domain by Sierra, Alicia Armella, Loureiro, María Eugenia, Esperante, Sebastián, Borkosky, Silvia Susana, Gallo, Giovanna L, de Prat Gay, Gonzalo, Lopez, Nora

“…The mammarenavirus Junín (JUNV) is the causative agent of Argentine hemorrhagic fever, a severe disease of public health concern. The most abundant viral…”
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Long-lasting immunoprotective and therapeutic effects of a hyperstable E7 oligomer based vaccine in a murine human papillomavirus tumor model by Cerutti, María L., Alonso, Leonardo G., Tatti, Silvio, de Prat-Gay, Gonzalo

“…Cervical cancer and many other anogenital and oropharyngeal carcinomas are strongly associated with high‐risk human papillomavirus (HPV) persistent infections…”
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Cytosolic accumulation of HPV16 E7 oligomers supports different transformation routes for the prototypic viral oncoprotein: The amyloid–cancer connection by Dantur, Karina, Alonso, Leonardo, Castaño, Eduardo, Morelli, Laura, Centeno‐Crowley, Juan Manuel, Vighi, Susana, de Prat‐Gay, Gonzalo

“…E7 is the major transforming activity in human papillomaviruses, a causal agent for cervical cancer. HPV16 E7 is a small protein with a natively unfolded…”
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Kinetic Recognition of the Retinoblastoma Tumor Suppressor by a Specific Protein Target by Chemes, Lucía B., Sánchez, Ignacio E., de Prat-Gay, Gonzalo

“…The retinoblastoma tumor suppressor (Rb) plays a key role in cell cycle control and is linked to various types of human cancer. Rb binds to the LxCxE motif,…”
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Kinetically driven refolding of the hyperstable EBNA1 origin DNA-binding dimeric β-barrel domain into amyloid-like spherical oligomers by Freire, Eleonora, Oddo, Cristian, Frappier, Lori, de Prat-Gay, Gonzalo

“…The Epstein‐Barr nuclear antigen 1 (EBNA1) is essential for DNA replication and episome segregation of the viral genome, and participates in other gene…”
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Conformational dissection of a viral intrinsically disordered domain involved in cellular transformation by Noval, María G, Gallo, Mariana, Perrone, Sebastián, Salvay, Andres G, Chemes, Lucía B, de Prat-Gay, Gonzalo

“…Intrinsic disorder is abundant in viral genomes and provides conformational plasticity to its protein products. In order to gain insight into its…”
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