Search Results - "Prasetyanti, Pramudita R."

Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells by Kemper, Kristel, Prasetyanti, Pramudita R., De Lau, Wim, Rodermond, Hans, Clevers, Hans, Medema, Jan Paul

“…In colorectal cancer (CRC), a subpopulation of tumor cells, called cancer stem cell (CSC) fraction, is suggested to be responsible for tumor initiation,…”
Get full text

Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients by de Sousa E Melo, Felipe, Colak, Selcuk, Buikhuisen, Joyce, Koster, Jan, Cameron, Kate, de Jong, Joan H., Tuynman, Jurriaan B., Prasetyanti, Pramudita R., Fessler, Evelyn, van den Bergh, Saskia P., Rodermond, Hans, Dekker, Evelien, van der Loos, Chris M., Pals, Steven T., van de Vijver, Marc J., Versteeg, Rogier, Richel, Dick J., Vermeulen, Louis, Medema, Jan Paul

“…Gene signatures derived from cancer stem cells (CSCs) predict tumor recurrence for many forms of cancer. Here, we derived a gene signature for colorectal CSCs…”
Get full text

Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts by van der Heijden, Maartje, Miedema, Daniël M., Waclaw, Bartlomiej, Veenstra, Veronique L., Lecca, Maria C., Nijman, Lisanne E., van Dijk, Erik, van Neerven, Sanne M., Lodestijn, Sophie C., Lenos, Kristiaan J., de Groot, Nina E., Prasetyanti, Pramudita R., Varea, Andrea Arricibita, Winton, Douglas J., Medema, Jan Paul, Morrissey, Edward, Ylstra, Bauke, Nowak, Martin A., Bijlsma, Maarten F., Vermeulen, Louis

“…Cancer evolution is predominantly studied by focusing on differences in the genetic characteristics of malignant cells within tumors. However, the…”
Get full text

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype by Fessler, Evelyn, Drost, Jarno, van Hooff, Sander R, Linnekamp, Janneke F, Wang, Xin, Jansen, Marnix, De Sousa E Melo, Felipe, Prasetyanti, Pramudita R, IJspeert, Joep EG, Franitza, Marek, Nürnberg, Peter, van Noesel, Carel JM, Dekker, Evelien, Vermeulen, Louis, Clevers, Hans, Medema, Jan Paul

“…The heterogeneous nature of colorectal cancer (CRC) complicates prognosis and is suggested to be a determining factor in the efficacy of adjuvant therapy for…”
Get full text

Intra-tumor heterogeneity from a cancer stem cell perspective by Prasetyanti, Pramudita R, Medema, Jan Paul

“…Tumor heterogeneity represents an ongoing challenge in the field of cancer therapy. Heterogeneity is evident between cancers from different patients…”
Get full text

High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors by Koudijs, Marco J, Klijn, Christiaan, van der Weyden, Louise, Kool, Jaap, ten Hoeve, Jelle, Sie, Daoud, Prasetyanti, Pramudita R, Schut, Eva, Kas, Sjors, Whipp, Theodore, Cuppen, Edwin, Wessels, Lodewyk, Adams, David J, Jonkers, Jos

“…Retroviral and transposon-based insertional mutagenesis (IM) screens are widely used for cancer gene discovery in mice. Exploiting the full potential of IM…”
Get full text

Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models by Linnekamp, Janneke F., Hooff, Sander R. van, Prasetyanti, Pramudita R., Kandimalla, Raju, Buikhuisen, Joyce Y., Fessler, Evelyn, Ramesh, Prashanthi, Lee, Kelly A. S. T., Bochove, Grehor G. W., de Jong, Johan H., Cameron, Kate, Leersum, Ronald van, Rodermond, Hans M., Franitza, Marek, Nürnberg, Peter, Mangiapane, Laura R., Wang, Xin, Clevers, Hans, Vermeulen, Louis, Stassi, Giorgio, Medema, Jan Paul

“…Colorectal cancer (CRC) is a highly heterogeneous disease both from a molecular and clinical perspective. Several distinct molecular entities, such as…”
Get full text

Capturing colorectal cancer inter‐tumor heterogeneity in patient‐derived xenograft (PDX) models by Prasetyanti, Pramudita R., Hooff, Sander R., Herwaarden, Tessa, Vries, Nathalie, Kalloe, Kieshen, Rodermond, Hans, Leersum, Ronald, Jong, Joan H., Franitza, Marek, Nürnberg, Peter, Todaro, Matilde, Stassi, Giorgio, Medema, Jan Paul

“…Patient‐derived xenograft (PDX) models have become an important asset in translational cancer research. However, to provide a robust preclinical platform, PDXs…”
Get full text

HER-3: hub for escape mechanisms by Capone, Emily, Prasetyanti, Pramudita R, Sala, Gianluca

Get full text

ErbB-3 activation by NRG-1β sustains growth and promotes vemurafenib resistance in BRAF-V600E colon cancer stem cells (CSCs) by Prasetyanti, Pramudita R, Capone, Emily, Barcaroli, Daniela, D'Agostino, Daniela, Volpe, Silvia, Benfante, Antonina, van Hooff, Sander, Iacobelli, Valentina, Rossi, Cosmo, Iacobelli, Stefano, Medema, Jan Paul, De Laurenzi, Vincenzo, Sala, Gianluca

“…Approximately 5-10% of metastatic colorectal cancers harbor a BRAF-V600E mutation, which is correlated with resistance to EGFR-targeted therapies and worse…”
Get full text

Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models by Linnekamp, Janneke F., Hooff, Sander R. van, Prasetyanti, Pramudita R., Kandimalla, Raju, Buikhuisen, Joyce Y., Fessler, Evelyn, Ramesh, Prashanthi, Lee, Kelly A. S. T., Bochove, Grehor G. W., de Jong, Johan H., Cameron, Kate, Leersum, Ronald van, Rodermond, Hans M., Franitza, Marek, Nürnberg, Peter, Mangiapane, Laura R., Wang, Xin, Clevers, Hans, Vermeulen, Louis, Stassi, Giorgio, Medema, Jan Paul

Get full text

Abstract 3193: Development of a colon cancer model system reveals epithelial contribution to poor-prognosis gene signatures by Prasetyanti, Pramudita R., van Hooff, Sander R., Rodermond, Hans M., van Herwaarden, Tessa, Kalloe, Kieshen, de Vries, Nathalie R., van Leersum, Ronals, de jong, Joan H., Fessler, Evelyn, Baldi, Nicolo, Stassi, Giorgio, Medema, Jan Paul

“…Abstract Background: Recent consensus on molecular classification categorizes colorectal cancer (CRC) into 4 robust subtypes: CMS1 (epithelial-MSI), CMS2…”
Get full text

Isolation and propagation of colon cancer stem cells by Prasetyanti, Pramudita R, Zimberlin, Cheryl, De Sousa E Melo, Felipe, Medema, Jan Paul

“…The design of tissue culture conditions that faithfully reproduce the characteristics of cells in their native environment remains one of the main challenges…”
Get more information

Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon by Prasetyanti, Pramudita Ramadhina, Zimberlin, Cheryl Doreen, Bots, Michael, Vermeulen, Louis, Melo, Felipe De Sousa E, Medema, Jan Paul

“…Colon cancer stem cells are shown to be the self-renewing cells within a tumor that give rise to all lineages of more differentiated tumor cells. In this…”
Get full text