Search Results - "Prasanth, Supriya G"
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Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB
Published in PLoS genetics (01-03-2013)“…The long noncoding MALAT1 RNA is upregulated in cancer tissues and its elevated expression is associated with hyper-proliferation, but the underlying mechanism…”
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A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability
Published in PLoS genetics (29-11-2018)“…The human genome encodes thousands of long noncoding RNA (lncRNA) genes; the function of majority of them is poorly understood. Aberrant expression of a…”
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Optical measurement of cycle-dependent cell growth
Published in Proceedings of the National Academy of Sciences - PNAS (09-08-2011)“…Determining the growth patterns of single cells offers answers to some of the most elusive questions in contemporary cell biology: how cell growth is regulated…”
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The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation
Published in Molecular cell (24-09-2010)“…Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased transcriptome and proteomic complexity. The serine/arginine (SR)…”
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Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer
Published in Oncotarget (28-06-2016)“…MALAT1 (metastasis associated lung adenocarcinoma transcript1) is a conserved long non-coding RNA, known to regulate gene expression by modulating…”
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MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs
Published in Nucleic acids research (02-11-2018)“…Abstract Long non-coding RNAs (lncRNAs) regulate vital biological processes, including cell proliferation, differentiation and development. A subclass of…”
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Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization
Published in Proceedings of the National Academy of Sciences - PNAS (24-08-2010)“…The origin recognition complex (ORC) is a DNA replication initiator protein also known to be involved in diverse cellular functions including gene silencing,…”
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Chromatin's Influence on Pre-Replication Complex Assembly and Function
Published in Biology (Basel, Switzerland) (27-02-2024)“…In all eukaryotes, the initiation of DNA replication requires a stepwise assembly of factors onto the origins of DNA replication. This is pioneered by the…”
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Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins
Published in Genes & development (01-02-2022)“…The BEN domain is a recently recognized DNA binding module that is present in diverse metazoans and certain viruses. Several BEN domain factors are known as…”
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Orc1 Controls Centriole and Centrosome Copy Number in Human Cells
Published in Science (American Association for the Advancement of Science) (06-02-2009)“…Centrosomes, each containing a pair of centrioles, organize microtubules in animal cells, particularly during mitosis. DNA and centrosomes are normally…”
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PCNA-mediated stabilization of E3 ligase RFWD3 at the replication fork is essential for DNA replication
Published in Proceedings of the National Academy of Sciences - PNAS (26-12-2018)“…RING finger and WD repeat domain-containing protein 3 (RFWD3) is an E3 ligase known to facilitate homologous recombination by removing replication protein A…”
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LncRNA-mediated regulation of SOX9 expression in basal subtype breast cancer cells
Published in RNA (Cambridge) (01-02-2020)“…Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer (BC) subtypes with a poor prognosis and high recurrence rate. Recent studies…”
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ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins
Published in Nucleic acids research (20-04-2017)“…Adenosine deaminases acting on RNA (ADARs) catalyze the editing of adenosine residues to inosine (A-to-I) within RNA sequences, mostly in the introns and UTRs…”
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A WD-Repeat Protein Stabilizes ORC Binding to Chromatin
Published in Molecular cell (08-10-2010)“…Origin recognition complex (ORC) plays critical roles in the initiation of DNA replication and cell-cycle progression. In metazoans, ORC associates with origin…”
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BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase
Published in Proceedings of the National Academy of Sciences - PNAS (07-07-2015)“…Ribosome biogenesis dictates the translational capacity of cells. Several mechanisms establish and maintain transcriptional output from eukaryotic ribosomal…”
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Dynamic Association of ORCA with Prereplicative Complex Components Regulates DNA Replication Initiation
Published in Molecular and Cellular Biology (01-08-2012)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Monoallelically expressed noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression
Published in eLife (19-01-2024)“…Out of the several hundred copies of genes arranged in the nucleolar organizing regions (NOR) of the five human acrocentric chromosomes, ~50% remain…”
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Orc2 protects ORCA from ubiquitin-mediated degradation
Published in Cell cycle (Georgetown, Tex.) (01-10-2012)“…Origin recognition complex (ORC) is highly dynamic, with several ORC subunits getting posttranslationally modified by phosphorylation or ubiquitination in a…”
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The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway
Published in eLife (27-10-2020)“…Cell cycle is a cellular process that is subject to stringent control. In contrast to the wealth of knowledge of proteins controlling the cell cycle, very…”
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Paraspeckles modulate the intranuclear distribution of paraspeckle-associated Ctn RNA
Published in Scientific reports (26-09-2016)“…Paraspeckles are sub-nuclear domains that are nucleated by long noncoding RNA Neat1 . While interaction of protein components of paraspeckles and Neat1 is…”
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