Search Results - "Prasanth, Kannanganattu V"

Nuclear Long Noncoding RNAs: Key Regulators of Gene Expression by Sun, Qinyu, Hao, Qinyu, Prasanth, Kannanganattu V.

“…A significant portion of the human genome encodes genes that transcribe long nonprotein-coding RNAs (lncRNAs). A large number of lncRNAs localize in the…”
Get full text

Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB by Tripathi, Vidisha, Shen, Zhen, Chakraborty, Arindam, Giri, Sumanprava, Freier, Susan M, Wu, Xiaolin, Zhang, Yongqing, Gorospe, Myriam, Prasanth, Supriya G, Lal, Ashish, Prasanth, Kannanganattu V

“…The long noncoding MALAT1 RNA is upregulated in cancer tissues and its elevated expression is associated with hyper-proliferation, but the underlying mechanism…”
Get full text

Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution by Fei, Jingyi, Jadaliha, Mahdieh, Harmon, Tyler S, Li, Isaac T S, Hua, Boyang, Hao, Qinyu, Holehouse, Alex S, Reyer, Matthew, Sun, Qinyu, Freier, Susan M, Pappu, Rohit V, Prasanth, Kannanganattu V, Ha, Taekjip

“…Nuclear speckles are self-assembled organelles composed of RNAs and proteins. They are proposed to act as structural domains that control distinct steps in…”
Get full text

Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation by Malakar, Pushkar, Shilo, Asaf, Mogilevsky, Adi, Stein, Ilan, Pikarsky, Eli, Nevo, Yuval, Benyamini, Hadar, Elgavish, Sharona, Zong, Xinying, Prasanth, Kannanganattu V, Karni, Rotem

“…Several long noncoding RNAs (lncRNA) are abrogated in cancer but their precise contributions to oncogenesis are still emerging. Here we report that the lncRNA…”
Get full text

A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability by Jadaliha, Mahdieh, Gholamalamdari, Omid, Tang, Wei, Zhang, Yang, Petracovici, Ana, Hao, Qinyu, Tariq, Aamira, Kim, Tae Gyoon, Holton, Sarah E, Singh, Deepak K, Li, Xiao Ling, Freier, Susan M, Ambs, Stefan, Bhargava, Rohit, Lal, Ashish, Prasanth, Supriya G, Ma, Jian, Prasanth, Kannanganattu V

“…The human genome encodes thousands of long noncoding RNA (lncRNA) genes; the function of majority of them is poorly understood. Aberrant expression of a…”
Get full text

Regulatory roles of nucleolus organizer region-derived long non-coding RNAs by Hao, Qinyu, Prasanth, Kannanganattu V.

“…The nucleolus is the largest sub-nuclear domain, serving primarily as the place for ribosome biogenesis. A delicately regulated function of the nucleolus is…”
Get full text

Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum by Prasanth, Kannanganattu V, Spector, David L

“…A large portion of the eukaryotic genome is transcribed as noncoding RNAs (ncRNAs). While once thought of primarily as "junk," recent studies indicate that a…”
Get full text

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation by Tripathi, Vidisha, Ellis, Jonathan D., Shen, Zhen, Song, David Y., Pan, Qun, Watt, Andrew T., Freier, Susan M., Bennett, C. Frank, Sharma, Alok, Bubulya, Paula A., Blencowe, Benjamin J., Prasanth, Supriya G., Prasanth, Kannanganattu V.

“…Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased transcriptome and proteomic complexity. The serine/arginine (SR)…”
Get full text

A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression by Bernard, Delphine, Prasanth, Kannanganattu V, Tripathi, Vidisha, Colasse, Sabrina, Nakamura, Tetsuya, Xuan, Zhenyu, Zhang, Michael Q, Sedel, Frédéric, Jourdren, Laurent, Coulpier, Fanny, Triller, Antoine, Spector, David L, Bessis, Alain

“…A growing number of long nuclear‐retained non‐coding RNAs (ncRNAs) have recently been described. However, few functions have been elucidated for these ncRNAs…”
Get full text

Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer by Jadaliha, Mahdieh, Zong, Xinying, Malakar, Pushkar, Ray, Tania, Singh, Deepak K, Freier, Susan M, Jensen, Tor, Prasanth, Supriya G, Karni, Rotem, Ray, Partha S, Prasanth, Kannanganattu V

“…MALAT1 (metastasis associated lung adenocarcinoma transcript1) is a conserved long non-coding RNA, known to regulate gene expression by modulating…”
Get full text

MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs by Sun, Qinyu, Tripathi, Vidisha, Yoon, Je-Hyun, Singh, Deepak K, Hao, Qinyu, Min, Kyung-Won, Davila, Sylvia, Zealy, Richard W, Li, Xiao Ling, Polycarpou-Schwarz, Maria, Lehrmann, Elin, Zhang, Yongqing, Becker, Kevin G, Freier, Susan M, Zhu, Yuelin, Diederichs, Sven, Prasanth, Supriya G, Lal, Ashish, Gorospe, Myriam, Prasanth, Kannanganattu V

“…Abstract Long non-coding RNAs (lncRNAs) regulate vital biological processes, including cell proliferation, differentiation and development. A subclass of…”
Get full text

Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization by Prasanth, Supriya G., Shen, Zhen, Prasanth, Kannanganattu V., Stillman, Bruce

“…The origin recognition complex (ORC) is a DNA replication initiator protein also known to be involved in diverse cellular functions including gene silencing,…”
Get full text

Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer by Li, Xiao Ling, Subramanian, Murugan, Jones, Matthew F., Chaudhary, Ritu, Singh, Deepak K., Zong, Xinying, Gryder, Berkley, Sindri, Sivasish, Mo, Min, Schetter, Aaron, Wen, Xinyu, Parvathaneni, Swetha, Kazandjian, Dickran, Jenkins, Lisa M., Tang, Wei, Elloumi, Fathi, Martindale, Jennifer L., Huarte, Maite, Zhu, Yuelin, Robles, Ana I., Frier, Susan M., Rigo, Frank, Cam, Maggie, Ambs, Stefan, Sharma, Sudha, Harris, Curtis C., Dasso, Mary, Prasanth, Kannanganattu V., Lal, Ashish

“…Basal p53 levels are tightly suppressed under normal conditions. Disrupting this regulation results in elevated p53 levels to induce cell cycle arrest,…”
Get full text

Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3 by Chaudhary, Ritu, Gryder, Berkley, Woods, Wendy S, Subramanian, Murugan, Jones, Matthew F, Li, Xiao Ling, Jenkins, Lisa M, Shabalina, Svetlana A, Mo, Min, Dasso, Mary, Yang, Yuan, Wakefield, Lalage M, Zhu, Yuelin, Frier, Susan M, Moriarity, Branden S, Prasanth, Kannanganattu V, Perez-Pinera, Pablo, Lal, Ashish

“…Thousands of long noncoding RNAs (lncRNAs) have been discovered, yet the function of the vast majority remains unclear. Here, we show that a p53-regulated…”
Get full text

PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity by Yoon, Je-Hyun, De, Supriyo, Srikantan, Subramanya, Abdelmohsen, Kotb, Grammatikakis, Ioannis, Kim, Jiyoung, Kim, Kyoung Mi, Noh, Ji Heon, White, Elizabeth J. F., Martindale, Jennifer L., Yang, Xiaoling, Kang, Min-Ju, Wood, William H., Hooten, Nicole Noren, Evans, Michele K., Becker, Kevin G., Tripathi, Vidisha, Prasanth, Kannanganattu V., Wilson, Gerald M., Tuschl, Thomas, Ingolia, Nicholas T., Hafner, Markus, Gorospe, Myriam

“…Post-transcriptional gene regulation is robustly regulated by RNA-binding proteins (RBPs). Here we describe the collection of RNAs regulated by AUF1…”
Get full text

Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death by Arif, Waqar, Mathur, Bhoomika, Saikali, Michael F., Chembazhi, Ullas V., Toohill, Katelyn, Song, You Jin, Hao, Qinyu, Karimi, Saman, Blue, Steven M., Yee, Brian A., Van Nostrand, Eric L., Bangru, Sushant, Guzman, Grace, Yeo, Gene W., Prasanth, Kannanganattu V., Anakk, Sayeepriyadarshini, Cummins, Carolyn L., Kalsotra, Auinash

“…Regulation of RNA processing contributes profoundly to tissue development and physiology. Here, we report that serine-arginine-rich splicing factor 1 (SRSF1)…”
Get full text

PCNA-mediated stabilization of E3 ligase RFWD3 at the replication fork is essential for DNA replication by Lin, Yo-Chuen, Wang, Yating, Hsu, Rosaline, Giri, Sumanprava, Wopat, Susan, Arif, Mariam K., Chakraborty, Arindam, Prasanth, Kannanganattu V., Prasanth, Supriya G.

“…RING finger and WD repeat domain-containing protein 3 (RFWD3) is an E3 ligase known to facilitate homologous recombination by removing replication protein A…”
Get full text

SRSF1 regulates the assembly of pre-mRNA processing factors in nuclear speckles by Tripathi, Vidisha, Song, David Y, Zong, Xinying, Shevtsov, Sergey P, Hearn, Stephen, Fu, Xiang-Dong, Dundr, Miroslav, Prasanth, Kannanganattu V

“…The mammalian cell nucleus is compartmentalized into nonmembranous subnuclear domains that regulate key nuclear functions. Nuclear speckles are subnuclear…”
Get full text

Monoallelically expressed noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression by Hao, Qinyu, Liu, Minxue, Daulatabad, Swapna Vidhur, Gaffari, Saba, Song, You Jin, Srivastava, Rajneesh, Bhaskar, Shivang, Moitra, Anurupa, Mangan, Hazel, Tseng, Elizabeth, Gilmore, Rachel B, Frier, Susan M, Chen, Xin, Wang, Chengliang, Huang, Sui, Chamberlain, Stormy, Jin, Hong, Korlach, Jonas, McStay, Brian, Sinha, Saurabh, Janga, Sarath Chandra, Prasanth, Supriya G, Prasanth, Kannanganattu V

“…Out of the several hundred copies of genes arranged in the nucleolar organizing regions (NOR) of the five human acrocentric chromosomes, ~50% remain…”
Get full text

LncRNA-mediated regulation of SOX9 expression in basal subtype breast cancer cells by Tariq, Aamira, Hao, Qinyu, Sun, Qinyu, Singh, Deepak K, Jadaliha, Mahdieh, Zhang, Yang, Chetlangia, Neha, Ma, Jian, Holton, Sarah E, Bhargava, Rohit, Lal, Ashish, Prasanth, Supriya G, Prasanth, Kannanganattu V

“…Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer (BC) subtypes with a poor prognosis and high recurrence rate. Recent studies…”
Get full text