Search Results - "Prasada Rao S. Kodavanti"

Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus Are Sex-Specific by Valdez, Matthew C, Freeborn, Danielle L, Vulimiri, Padmaja, Valdez, Joseph M, Kodavanti, Urmila P, Kodavanti, Prasada Rao S

“…Exposure to a prototypic air pollutant ozone (O ) has been associated with the activation of neuroendocrine stress response along with neural changes in…”
Get full text

Interaction of Diet and Ozone Exposure on Oxidative Stress Parameters within Specific Brain Regions of Male Brown Norway Rats by Valdez, Joseph M, Johnstone, Andrew F M, Richards, Judy E, Schmid, Judith E, Royland, Joyce E, Kodavanti, Prasada Rao S

“…Oxidative stress (OS) contributes to the neurological and cardio/pulmonary effects caused by adverse metabolic states and air pollutants such as ozone (O₃)…”
Get full text

Influence of Mild Chronic Stress and Social Isolation on Acute Ozone-Induced Alterations in Stress Biomarkers and Brain-Region-Specific Gene Expression in Male Wistar–Kyoto Rats by Valdez, Matthew C, Freeborn, Danielle L, Valdez, Joseph M, Henriquez, Andres R, Snow, Samantha J, Jackson, Thomas W, Kodavanti, Prasada Rao S, Kodavanti, Urmila P

“…Individuals with psychosocial stress often experience an exaggerated response to air pollutants. Ozone (O3) exposure has been associated with the activation of…”
Get full text

Age- and Organ-Specific Differences in Mitochondrial Bioenergetics in Brown Norway Rats by Sullivan, Patrick G., MacPhail, Robert C., Royland, Joyce E., Valdez, Matthew, Pandya, Jignesh D., Kodavanti, Prasada Rao S.

“…Mitochondria play a central role in energy homeostasis and act as regulatory checkpoints for downstream metabolic responses and cell senescence processes…”
Get full text

Developmental exposure to a commercial PBDE mixture: effects on protein networks in the cerebellum and hippocampus of rats by Kodavanti, Prasada Rao S, Royland, Joyce E, Osorio, Cristina, Winnik, Witold M, Ortiz, Pedro, Lei, Lei, Ramabhadran, Ram, Alzate, Oscar

“…Polybrominated diphenyl ethers (PBDEs) are structurally similar to polychlorinated biphenyls (PCBs) and have both central (learning and memory deficits) and…”
Get full text

Mitochondrial Bioenergetics in Brain Following Ozone Exposure in Rats Maintained on Coconut, Fish and Olive Oil-Rich Diets by Valdez, Matthew C, Freeborn, Danielle, Valdez, Joseph M, Johnstone, Andrew F M, Snow, Samantha J, Tennant, Alan H, Kodavanti, Urmila P, Kodavanti, Prasada Rao S

“…Dietary supplementation with omega-3 and omega-6 fatty acids offer cardioprotection against air pollution, but these protections have not been established in…”
Get full text

Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71 by Kozlova, Elena V., Valdez, Matthew C., Denys, Maximillian E., Bishay, Anthony E., Krum, Julia M., Rabbani, Kayhon M., Carrillo, Valeria, Gonzalez, Gwendolyn M., Lampel, Gregory, Tran, Jasmin D., Vazquez, Brigitte M., Anchondo, Laura M., Uddin, Syed A., Huffman, Nicole M., Monarrez, Eduardo, Olomi, Duraan S., Chinthirla, Bhuvaneswari D., Hartman, Richard E., Kodavanti, Prasada Rao S., Chompre, Gladys, Phillips, Allison L., Stapleton, Heather M., Henkelmann, Bernhard, Schramm, Karl-Werner, Curras-Collazo, Margarita C.

“…Polybrominated diphenyl ethers (PBDEs) are ubiquitous persistent organic pollutants (POPs) that are known neuroendocrine disrupting chemicals with adverse…”
Get full text

Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes by Sueyoshi, Tatsuya, Li, Linhao, Wang, Hongbing, Moore, Rick, Kodavanti, Prasada Rao S, Lehmler, Hans-Joachim, Negishi, Masahiko, Birnbaum, Linda S

“…Polybrominated diphenyl ether BDE-47 (2,2',4,4'-tetrabromodiphenyl ether) is a thyroid hormone disruptor in mice; hepatic induction of various metabolic…”
Get full text

Occurrence of Polybrominated Biphenyls, Polybrominated Dibenzo-p-dioxins, and Polybrominated Dibenzofurans as Impurities in Commercial Polybrominated Diphenyl Ether Mixtures by Hanari, Nobuyasu, Kannan, Kurunthachalam, Okazawa, Tsuyoshi, Kodavanti, Prasada Rao S, Aldous, Kenneth M, Yamashita, Nobuyoshi

“…The objective of this study was to determine the concentrations and compositions of polybrominated biphenyls (PBBs), polybrominated dibenzo-p-dioxins (PBDDs),…”
Get full text

Atypical microglial response to biodiesel exhaust in healthy and hypertensive rats by Mumaw, Christen L, Surace, Michael, Levesque, Shannon, Kodavanti, Urmila P, Kodavanti, Prasada Rao S, Royland, Joyce E, Block, Michelle L

“…Accumulating evidence suggests a deleterious role for urban air pollution in central nervous system (CNS) diseases and neurodevelopmental disorders. Microglia,…”
Get full text

Acute in vitro effects on embryonic rat dorsal root ganglion (DRG) cultures by in silico predicted neurotoxic chemicals: Evaluations on cytotoxicity, neurite length, and neurophysiology by Johnstone, Andrew F.M., Mack, Cina M., Valdez, Matthew C., Shafer, Timothy J., LoPachin, Richard M., Herr, David W., Kodavanti, Prasada Rao S.

“…The Hard-Soft Acid and Base hypothesis can be used to predict the potential bio-reactivity (electrophilicity) of a chemical with intracellular proteins,…”
Get full text

Differential Effects of Commercial Polybrominated Diphenyl Ether and Polychlorinated Biphenyl Mixtures on Intracellular Signaling in Rat Brain in Vitro by Kodavanti, Prasada Rao S., Ward, Thomas R.

“…Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants and have been detected in human blood, adipose tissue, and breast milk…”
Get full text

Aroclor 1254, a developmental neurotoxicant, alters energy metabolism- and intracellular signaling-associated protein networks in rat cerebellum and hippocampus by Kodavanti, Prasada Rao S., Osorio, Cristina, Royland, Joyce E., Ramabhadran, Ram, Alzate, Oscar

“…The vast literature on the mode of action of polychlorinated biphenyls (PCBs) indicates that PCBs are a unique model for understanding the mechanisms of…”
Get full text

In Vitro Effects of Environmentally Relevant Polybrominated Diphenyl Ether (PBDE) Congeners on Calcium Buffering Mechanisms in Rat Brain by Coburn, Cary G., Currás-Collazo, Margarita C., Kodavanti, Prasada Rao S.

“…Polybrominated diphenyl ethers (PBDEs) are widely used as additive flame-retardants and have been detected in human blood, adipose tissue, and breast milk…”
Get full text

Ontogenetic Alterations in Molecular and Structural Correlates of Dendritic Growth after Developmental Exposure to Polychlorinated Biphenyls by Lein, Pamela J., Yang, Dongren, Adam D. Bachstetter, Tilson, Hugh A., Harry, G. Jean, Ronald F. Mervis, Prasada Rao S. Kodavanti

“…Objective: Perinatal exposure to polychlorinated biphenyls (PCBs) is associated with decreased IQ scores, impaired learning and memory, psychomotor…”
Get full text

Ozone-induced changes in oxidative stress parameters in brain regions of adult, middle-age, and senescent Brown Norway rats by Kodavanti, Prasada Rao S., Valdez, Matthew, Richards, Judy E., Agina-Obu, Datonye I., Phillips, Pamela M., Jarema, Kimberly A., Kodavanti, Urmila P.

“…A critical part of community based human health risk assessment following chemical exposure is identifying sources of susceptibility. Life stage is one such…”
Get full text

Neuroendocrine actions of organohalogens: Thyroid hormones, arginine vasopressin, and neuroplasticity by Kodavanti, Prasada Rao S, Curras-Collazo, Margarita C

“…Abstract Organohalogen compounds are global environmental pollutants. They are highly persistent, bioaccumulative, and cause adverse effects in humans and…”
Get full text

Identification of neural-relevant toxcast high-throughput assay intended gene targets: Applicability to neurotoxicity and neurotoxicant putative molecular initiating events by Mack, Cina M., Tsui-Bowen, Alethea, Smith, Alicia R., Jensen, Karl F., Kodavanti, Prasada Rao S., Moser, Virginia C., Mundy, William R., Shafer, Timothy J., Herr, David W.

“…The US EPA’s Toxicity Forecaster (ToxCast) is a suite of high-throughput in vitro assays to screen environmental toxicants and predict potential toxicity of…”
Get full text

The effects of ozone exposure and sedentary lifestyle on neuronal microglia and mitochondrial bioenergetics of female Long-Evans rats by Valdez, Matthew, Valdez, Joseph M., Freeborn, Danielle, Johnstone, Andrew F.M., Kodavanti, Prasada Rao S.

“…Ozone (O3) is a widespread air pollutant that produces cardiovascular and pulmonary dysfunction possibly mediated by activation of central stress centers…”
Get full text

Differential Effects of Two Lots of Aroclor 1254: Congener-Specific Analysis and Neurochemical End Points by Prasada Rao S. Kodavanti, Kannan, Narayanan, Yamashita, Nobuyoshi, Derr-Yellin, Ethel C., Ward, Thomas R., Burgin, Deborah E., Tilson, Hugh A., Birnbaum, Linda S.

“…Aroclor 1254 is a widely studied commercial polychlorinated biphenyl (PCB) mixture which, by definition, contains 54% chlorine by weight. Recent reports…”
Get full text