Search Results - "Prasad, Neha"

Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020 by Prasad, Neha K, Seiple, Ian B, Cirz, Ryan T, Rosenberg, Oren S

“…The World Health Organization (WHO) has warned that our current arsenal of antibiotics is not innovative enough to face impending infectious diseases,…”
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Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs by Kundert, Kale, Lucas, James E., Watters, Kyle E., Fellmann, Christof, Ng, Andrew H., Heineike, Benjamin M., Fitzsimmons, Christina M., Oakes, Benjamin L., Qu, Jiuxin, Prasad, Neha, Rosenberg, Oren S., Savage, David F., El-Samad, Hana, Doudna, Jennifer A., Kortemme, Tanja

“…The CRISPR-Cas9 system provides the ability to edit, repress, activate, or mark any gene (or DNA element) by pairing of a programmable single guide RNA (sgRNA)…”
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β-Lactone formation during product release from a nonribosomal peptide synthetase by Schaffer, Jason E, Reck, Margaret R, Prasad, Neha K, Wencewicz, Timothy A

“…In vitro reconstitution of five enzymes elucidates the biosynthetic pathway of obafluorin (Obi) and reveals that ObiF uses an unusual thioesterase domain to…”
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Transfer Learning with Kernel Methods by Radhakrishnan, Adityanarayanan, Ruiz Luyten, Max, Prasad, Neha, Uhler, Caroline

“…Transfer learning refers to the process of adapting a model trained on a source task to a target task. While kernel methods are conceptually and…”
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Modulating Pathogenesis with Mobile-CRISPRi by Qu, Jiuxin, Prasad, Neha K, Yu, Michelle A, Chen, Shuyan, Lyden, Amy, Herrera, Nadia, Silvis, Melanie R, Crawford, Emily, Looney, Mark R, Peters, Jason M, Rosenberg, Oren S

“…Conditionally essential (CE) genes are required by pathogenic bacteria to establish and maintain infections. CE genes encode virulence factors, such as…”
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Fluoride concentration in drinking water samples in Fiji by Prasad, Neha, Pushpaangaeli, Bernadette, Ram, Anumala, Maimanuku, Leenu

“…The main aim of this study was to determine the content of fluoride in drinking water from sources within the sampling areas for the National Oral Health…”
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eCD4-Ig Variants That More Potently Neutralize HIV-1 by Fetzer, Ina, Gardner, Matthew R, Davis-Gardner, Meredith E, Prasad, Neha R, Alfant, Barnett, Weber, Jesse A, Farzan, Michael

“…The human immunodeficiency virus type 1 (HIV-1) entry inhibitor eCD4-Ig is a fusion of CD4-Ig and a coreceptor-mimetic peptide. eCD4-Ig is markedly more potent…”
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AAV-delivered eCD4-Ig protects rhesus macaques from high-dose SIVmac239 challenges by Gardner, Matthew R, Fellinger, Christoph H, Kattenhorn, Lisa M, Davis-Gardner, Meredith E, Weber, Jesse A, Alfant, Barnett, Zhou, Amber S, Prasad, Neha R, Kondur, Hema R, Newton, Wendy A, Weisgrau, Kimberly L, Rakasz, Eva G, Lifson, Jeffrey D, Gao, Guangping, Schultz-Darken, Nancy, Farzan, Michael

“…A number of simian and simian human immunodeficiency viruses (SIV and SHIV, respectively) have been used to assess the efficacy of HIV-1 vaccine strategies…”
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A Coreceptor-Mimetic Peptide Enhances the Potency of V3-Glycan Antibodies by Fetzer, Ina, Davis-Gardner, Meredith E, Gardner, Matthew R, Alfant, Barnett, Weber, Jesse A, Prasad, Neha R, Zhou, Amber S, Farzan, Michael

“…Broadly neutralizing antibodies (bNAbs) target five major epitopes on the HIV-1 envelope glycoprotein (Env). The most potent bNAbs have median half-maximal…”
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Two sides of the same coin: A qualitative exploration of experiential and perceptual factors which influence the clinical interaction between physicians and Anabolic-Androgenic Steroid using patients in the UK by Ainsworth, Neha Prasad, Thrower, Sam N, Petróczi, Andrea

“…•Roles and expectations of doctors and AAS users are poorly understood.•AAS users withhold disclosure of their AAS use as a stigma-reduction mechanism.•Poor…”
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Nipah virus: A review on epidemiological characteristics and outbreaks to inform public health decision making by Ambat, Aishwarya S., Zubair, Sabah M., Prasad, Neha, Pundir, Prachi, Rajwar, Eti, Patil, Divya S., Mangad, Praveen

“…The objectives of this review were to understand the epidemiology and outbreak of NiV infection and to discuss the preventive and control measures across…”
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CD4-Induced Antibodies Promote Association of the HIV-1 Envelope Glycoprotein with CD4-Binding Site Antibodies by Gardner, Matthew R, Fellinger, Christoph H, Prasad, Neha R, Zhou, Amber S, Kondur, Hema R, Joshi, Vinita R, Quinlan, Brian D, Farzan, Michael

“…The HIV-1 envelope glycoprotein (Env) is a trimer of gp120/gp41 heterodimers that mediates viral entry. Env binds cellular CD4, an association which stabilizes…”
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Home Automation Using Chatbot and Voice Assistant by Kadali, Bhavyasri, Prasad, Neha, Kudav, Pranaya, Deshpande, Manoj

“…In a world with ever increasing needs for comfort, human race is relying more and more on technological advancements to find solutions to their problems. Home…”
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A systematic review to determine the most effective interventions to increase water intake by Chua, Teresa X.W., Prasad, Neha S., Rangan, Gopala K., Allman-Farinelli, Margaret, Rangan, Anna M.

“…Background Maintaining adequate fluid intake has been hypothesized to be beneficial for the progression of chronic kidney disease (CKD). The aim of this study…”
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Heat, Oriental sore, and HIV by Prasad, Neha, MBBS, Ghiya, Bhikiam C, Prof, Bumb, Ram A, Prof, Kaushal, Himanshu, MSc, Saboskar, Anjali A, MD, Lezama-Davila, Claudio M, PhD, Salotra, Poonam, PhD, Satoskar, Abhay R, Prof

“…Both patients have remained disease free for a year after treatment. [...] radiofrequency heat therapy should be considered as first-line treatment for…”
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A Case of Weil's Disease/ Fiedler Disease by Prasad, S Neha, Manam, Kavya

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A pilot randomised controlled trial of the feasibility of using body scan and isometric exercises for reducing urge to smoke in a smoking cessation clinic by Al-Chalabi, Lemees, Prasad, Neha, Steed, Lucy, Stenner, Sarah, Aveyard, Paul, Beach, Jane, Ussher, Michael

“…The main cause of relapse in smokers attempting to quit is inability to resist urges to smoke. Pharmacotherapy ameliorates but does not entirely prevent urges…”
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The DeCAMFounder: nonlinear causal discovery in the presence of hidden variables by Agrawal, Raj, Squires, Chandler, Prasad, Neha, Uhler, Caroline

“…Abstract Many real-world decision-making tasks require learning causal relationships between a set of variables. Traditional causal discovery methods, however,…”
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A Pooled CRISPRi Screen to Probe Pseudomonas Aeruginosa Gene Vulnerability During Murine Lung Infection and Phage Predation by Prasad, Neha

“…Despite their extraordinary ability to cure infectious diseases, most antibiotics have dose-limiting, off-target toxicities that impede the clinical…”
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Role of Plant-Based Anticancer Compounds in Treatment of Breast Cancer by Thakur, Ankita, Prasad, Neha, Raina, Kirti, Sharma, Rohit, Chaudhary, Ashun

“…Purpose of Review Breast cancer (BC) is the most prevalent malignant disease occurring in women globally. The most common treatment options include…”
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