Search Results - "Prange, H"

Transcriptional and epigenetic regulation of macrophages in atherosclerosis by Kuznetsova, Tatyana, Prange, Koen H. M., Glass, Christopher K., de Winther, Menno P. J.

“…Monocytes and macrophages provide defence against pathogens and danger signals. These cells respond to stimulation in a fast and stimulus-specific manner by…”
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Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques by Baardman, Jeroen, Verberk, Sanne G. S., van der Velden, Saskia, Gijbels, Marion J. J., van Roomen, Cindy P. P. A., Sluimer, Judith C., Broos, Jelle Y., Griffith, Guillermo R., Prange, Koen H. M., van Weeghel, Michel, Lakbir, Soufyan, Molenaar, Douwe, Meinster, Elisa, Neele, Annette E., Kooij, Gijs, de Vries, Helga E., Lutgens, Esther, Wellen, Kathryn E., de Winther, Menno P. J., Van den Bossche, Jan

“…Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic…”
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Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease by Lacy, Michael, Bürger, Christina, Shami, Annelie, Ahmadsei, Maiwand, Winkels, Holger, Nitz, Katrin, van Tiel, Claudia M., Seijkens, Tom T. P., Kusters, Pascal J. H., Karshovka, Ela, Prange, Koen H. M., Wu, Yuting, Brouns, Sanne L. N., Unterlugauer, Sigrid, Kuijpers, Marijke J. E., Reiche, Myrthe E., Steffens, Sabine, Edsfeldt, Andreas, Megens, Remco T. A., Heemskerk, Johan W. M., Goncalves, Isabel, Weber, Christian, Gerdes, Norbert, Atzler, Dorothee, Lutgens, Esther

“…Atherosclerosis is a major underlying cause of cardiovascular disease. Previous studies showed that inhibition of the co-stimulatory CD40 ligand (CD40L)-CD40…”
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MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia by Prange, K H M, Mandoli, A, Kuznetsova, T, Wang, S-Y, Sotoca, A M, Marneth, A E, van der Reijden, B A, Stunnenberg, H G, Martens, J H A

“…In 11q23 leukemias, the N-terminal part of the mixed lineage leukemia (MLL) gene is fused to >60 different partner genes. In order to define a core set of MLL…”
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Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study by Otto, M, Cepek, L, Ratzka, P, Doehlinger, S, Boekhoff, I, Wiltfang, J, Irle, E, Pergande, G, Ellers-Lenz, B, Windl, O, Kretzschmar, H A, Poser, S, Prange, H

“…In cell culture experiments, flupirtine maleate (FLU), a triaminopyridine compound, was able to protect neuronal cells from apoptotic cell death induced by…”
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Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics by Depuydt, Marie A.C., Prange, Koen H.M., Slenders, Lotte, Örd, Tiit, Elbersen, Danny, Boltjes, Arjan, de Jager, Saskia C.A., Asselbergs, Folkert W., de Borst, Gert J., Aavik, Einari, Lönnberg, Tapio, Lutgens, Esther, Glass, Christopher K., den Ruijter, Hester M., Kaikkonen, Minna U., Bot, Ilze, Slütter, Bram, van der Laan, Sander W., Yla-Herttuala, Seppo, Mokry, Michal, Kuiper, Johan, de Winther, Menno P.J., Pasterkamp, Gerard

“…RATIONALE:Atherosclerotic lesions are known for their cellular heterogeneity, yet the molecular complexity within the cells of human plaques has not been fully…”
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Potent lipoprotein(a) lowering following apolipoprotein(a) antisense treatment reduces the pro-inflammatory activation of circulating monocytes in patients with elevated lipoprotein(a) by Stiekema, Lotte C A, Prange, Koen H M, Hoogeveen, Renate M, Verweij, Simone L, Kroon, Jeffrey, Schnitzler, Johan G, Dzobo, Kim E, Cupido, Arjen J, Tsimikas, Sotirios, Stroes, Erik S G, de Winther, Menno P J, Bahjat, Mahnoush

“…Abstract Aims Elevated lipoprotein(a) [Lp(a)] is strongly associated with an increased cardiovascular disease (CVD) risk. We previously reported that…”
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Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation by Schnitzler, Johan G., Hoogeveen, Renate M., Ali, Lubna, Prange, Koen H.M., Waissi, Farahnaz, van Weeghel, Michel, Bachmann, Julian C., Versloot, Miranda, Borrelli, Matthew J., Yeang, Calvin, De Kleijn, Dominique P.V., Houtkooper, Riekelt H., Koschinsky, Marlys L., de Winther, Menno P.J., Groen, Albert K., Witztum, Joseph L., Tsimikas, Sotirios, Stroes, Erik S.G., Kroon, Jeffrey

“…Patients with elevated levels of lipoprotein(a) [Lp(a)] are hallmarked by increased metabolic activity in the arterial wall on positron emission…”
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Impact of cholesterol on proinflammatory monocyte production by the bone marrow by Stiekema, Lotte C A, Willemsen, Lisa, Kaiser, Yannick, Prange, Koen H M, Wareham, Nicholas J, Boekholdt, S Matthijs, Kuijk, Carlijn, de Winther, Menno P J, Voermans, Carlijn, Nahrendorf, Matthias, Stroes, Erik S G, Kroon, Jeffrey

“…Abstract Aim Preclinical work indicates that low-density lipoprotein cholesterol (LDL-C) not only drives atherosclerosis by directing the innate immune…”
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A longitudinal prospective study of soluble adhesion molecules in acute stroke by BITSCH, A, KLENE, W, MURTADA, L, PRANGE, H, RIECKMANN, P

“…Activation of endothelial cells is a consequence of cerebral ischemia and leads to the expression of adhesion molecules such as intercellular adhesion molecule…”
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A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia by Baardman, Jeroen, Verberk, Sanne G.S., Prange, Koen H.M., van Weeghel, Michel, van der Velden, Saskia, Ryan, Dylan G., Wüst, Rob C.I., Neele, Annette E., Speijer, Dave, Denis, Simone W., Witte, Maarten E., Houtkooper, Riekelt H., O’neill, Luke A., Knatko, Elena V., Dinkova-Kostova, Albena T., Lutgens, Esther, de Winther, Menno P.J., Van den Bossche, Jan

“…Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and…”
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Pharmacokinetic optimisation of the treatment of bacterial central nervous system infections by NAU, R, SÖRGEL, F, PRANGE, H. W

“…Central nervous system (CNS) infections caused by bacteria with reduced sensitivity to antibacterials are an increasing worldwide challenge. In successfully…”
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Diacylglycerols and Lysophosphatidic Acid, Enriched on Lipoprotein(a), Contribute to Monocyte Inflammation by Dzobo, Kim E, Cupido, Arjen J, Mol, Barend M, Stiekema, Lotte C A, Versloot, Miranda, Winkelmeijer, Maaike, Peter, Jorge, Pennekamp, Anne-Marije, Havik, Stefan R, Vaz, Frédéric M, van Weeghel, Michel, Prange, Koen H M, Levels, Johannes H M, de Winther, Menno P J, Tsimikas, Sotirios, Groen, Albert K, Stroes, Erik S G, de Kleijn, Dominique P V, Kroon, Jeffrey

“…Oxidized phospholipids play a key role in the atherogenic potential of lipoprotein(a) (Lp[a]); however, Lp(a) is a complex particle that warrants research into…”
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Anti-inflammatory treatment influences neuronal apoptotic cell death in the dentate gyrus in experimental pneumococcal meningitis by ZYSK, G, BRÜCK, W, GERBER, J, BRÜCK, Y, PRANGE, H. W, NAU, R

“…Apoptotic neuronal death and the increase of neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) were studied in a rabbit model of experimental…”
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Neuron-specific enolase concentrations in blood as a prognostic parameter in cerebrovascular diseases by Schaarschmidt, H, Prange, H W, Reiber, H

“…To investigate the clinical relevance of plasma concentrations of neuron-specific enolase (NSE) in patients with severe cerebrovascular diseases, serial…”
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Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans by Benavente, Ernest Diez, Hartman, Robin J G, Sakkers, Tim R, Wesseling, Marian, Sloots, Yannicke, Slenders, Lotte, Boltjes, Arjan, Mol, Barend M, de Borst, Gert J, de Kleijn, Dominique P V, Prange, Koen H M, de Winther, Menno P J, Kuiper, Johan, Civelek, Mete, van der Laan, Sander W, Horvath, Steve, Onland-Moret, Charlotte, Mokry, Michal, Pasterkamp, Gerard, den Ruijter, Hester M

“…Epigenetic age estimators (clocks) are predictive of human mortality risk. However, it is not yet known whether the epigenetic age of atherosclerotic plaques…”
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Physiological consequences of oxygen-dependent chloride binding to hemoglobin by Prange, H. D, Shoemaker, J. L., Jr, Westen, E. A, Horstkotte, D. G, Pinshow, B

“…1  Medical Sciences Program, Indiana University, Bloomington, Indiana 47405-7005; and 2  Jacob Blaustein Institute for Desert Research and Department of Life…”
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Core hypothermia in multiple sclerosis: case report with magnetic resonance imaging localization of a thalamic lesion by Linker, R A, Mohr, A, Cepek, L, Gold, R, Prange, H

“…Hypothermia is a rare condition in multiple sclerosis (MS). We report on a patient with a longstanding secondary progressive MS and six episodes of recurring…”
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Female Gene Networks Are Expressed in Myofibroblast-Like Smooth Muscle Cells in Vulnerable Atherosclerotic Plaques by Diez Benavente, Ernest, Karnewar, Santosh, Buono, Michele, Mili, Eloi, Hartman, Robin J G, Kapteijn, Daniek, Slenders, Lotte, Daniels, Mark, Aherrahrou, Redouane, Reinberger, Tobias, Mol, Barend M, de Borst, Gert J, de Kleijn, Dominique P V, Prange, Koen H M, Depuydt, Marie A C, de Winther, Menno P J, Kuiper, Johan, Björkegren, Johan L M, Erdmann, Jeanette, Civelek, Mete, Mokry, Michal, Owens, Gary K, Pasterkamp, Gerard, den Ruijter, Hester M

“…Women presenting with coronary artery disease more often present with fibrous atherosclerotic plaques, which are currently understudied. Phenotypically…”
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The oncofusion protein FUS–ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia by Sotoca, A M, Prange, K H M, Reijnders, B, Mandoli, A, Nguyen, L N, Stunnenberg, H G, Martens, J H A

“…The ETS transcription factor ERG has been implicated as a major regulator of both normal and aberrant hematopoiesis. In acute myeloid leukemias harboring…”
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