Search Results - "Pramanik, Birendra N."

Application of LC/MS to proteomics studies: current status and future prospects by Chen, Guodong, Pramanik, Birendra N.

“…Liquid chromatography/mass spectrometry (LC/MS) has become a powerful technology in proteomics studies in drug discovery, including target protein…”
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LC-MS for protein characterization: current capabilities and future trends by Chen, Guodong, Pramanik, Birendra N

“…With advances in ionization methods and instrumentation, liquid chromatography (LC)/mass spectrometry (MS) has become a powerful technology for protein…”
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Microwave‐enhanced enzyme reaction for protein mapping by mass spectrometry: A new approach to protein digestion in minutes by Pramanik, Birendra N., Mirza, Urooj A., Ing, Yao Hain, Liu, Yan‐Hui, Bartner, Peter L., Weber, Patricia C., Bose, Ajay K.

“…Accelerated proteolytic cleavage of proteins under controlled microwave irradiation has been achieved. Selective peptide fragmentation by endoproteases trypsin…”
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Accurate mass measurements by Fourier transform mass spectrometry by Zhang, Li-Kang, Rempel, Don, Pramanik, Birendra N., Gross, Michael L.

“…The capability for accurate mass measurements is an important attribute of Fourier transform mass spectrometry (FTMS). Unlike other instrumental methods in…”
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Applications of LC/MS in structure identifications of small molecules and proteins in drug discovery by Chen, Guodong, Pramanik, Birendra N., Liu, Yan-Hui, Mirza, Urooj A.

“…With advancements in ionization methods and instrumentation, liquid chromatography/mass spectrometry (LC/MS) has become a powerful technology for the…”
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Mechanism of azole antifungal activity as determined by liquid chromatographic/mass spectrometric monitoring of ergosterol biosynthesis by Heimark, Larry, Shipkova, Petia, Greene, Jonathan, Munayyer, Hanan, Yarosh-Tomaine, Taisa, DiDomenico, Beth, Hare, Roberta, Pramanik, Birendra N.

“…A liquid chromatography/mass spectrometry (LC/MS) method for separation and characterization of ergosterol biosynthetic precursors was developed to study the…”
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Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange HR-LC/MS by Chen, Guodong, Daaro, Ibrahim, Pramanik, Birendra N, Piwinski, John J

“…In vitro drug metabolism study is an integral part of drug discovery process. In this report, we have described the application of LTQ-Orbitrap hybrid mass…”
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Comparative Mapping of Recombinant Proteins and Glycoproteins by Plasma Desorption and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry by Tsarbopoulos, Anthony, Karas, Michael, Strupat, Kerstin, Pramanik, Birendra N., Nagabhushan, Tattanahalli L., Hillenkamp, Franz

“…The mass spectrometric (MS) techniques of 252Cf-plasma desorption (PD) and matrix-assisted laser desorption/ionization (MALDI) are compared in the molecular…”
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Mass spectrometric detection of the noncovalent GDP-bound conformational state of the human H-ras protein by Ganguly, Ashit K, Pramanik, Birendra N, Tsarbopoulos, Anthony, Covey, Thomas R, Huang, Eric, Fuhrman, Shella A

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Mass spectrometric characterization of the isoforms in Escherichia coli recombinant DNA-derived interferon alpha-2b by Liu, Yan-Hui, Wylie, David, Zhao, Jia, Cure, Raymond, Cutler, Collette, Cannon-Carlson, Susan, Yang, Xiaoyu, Nagabhushan, Tattanahalli L., Pramanik, Birendra N.

“…The isoforms Iso-2, Iso-3, and Iso-4 of Escherichia coli-derived recombinant human interferon alpha-2b (rhIFN α-2b), generated by posttranslational…”
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Structural identification of trace level enol tautomer impurity by on-line hydrogen/deuterium exchange HR-LC/MS in a LTQ-Orbitrap hybrid mass spectrometer by Chen, Guodong, Khusid, Anatoliy, Daaro, Ibrahim, Irish, Patrick, Pramanik, Birendra N.

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Characterization of major degradation products of an adenosine A₂A receptor antagonist under stressed conditions by LC-MS and FT tandem MS analysis by Zhang, Li-Kang, Pramanik, Birendra N

“…Parkinson's disease (PD) is a very serious neurological disorder, and current methods of treatment fail to achieve long-term control. SCH 420814 is a potent,…”
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Screening and rank ordering of reversible mechanism-based inhibitors of Hepatitis C virus NS3 protease using electrospray ionization mass spectrometry by Liu, Yan-Hui, Ramanathan, Lata, Malcolm, Bruce, Njoroge, George, Chan, Tin-Yau, Pramanik, Birendra N.

“…An affinity‐selection study using size exclusion chromatography (SEC) combined with off‐line electrospray ionization mass spectrometry (ESI‐MS) was performed…”
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Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048) by Nomeir, Amin A, Pramanik, Birendra N, Heimark, Larry, Bennett, Frank, Veals, John, Bartner, Peter, Hilbert, Maryjane, Saksena, Anil, McNamara, Paul, Girijavallabhan, Viyyoor, Ganguly, Ashit K, Lovey, Raymond, Pike, Russell, Wang, Haiyan, Liu, Yi-Tsung, Kumari, Pramila, Korfmacher, Walter, Lin, Chin-Chung, Cacciapuoti, Anthony, Loebenberg, David, Hare, Roberta, Miller, George, Pickett, Cecil

“…Posaconazole (SCH 56592) is a novel triazole antifungal drug that is marketed in Europe and the United States under the trade name 'Noxafil' for prophylaxis…”
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Electrospray ionization mass spectrometry for the study of non-covalent complexes: an emerging technology by Pramanik, Birendra N., Bartner, Peter L., Mirza, Urooj A., Liu, Yan-Hui, Ganguly, Ashit K.

“…The detection of non‐covalent complexes in the mass range 19000–34000 Da, using electrospray ionization mass spectrometry (ESI‐MS), is reviewed. The examples…”
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Matrix Dependence of Metastable Fragmentation of Glycoproteins in MALDI TOF Mass Spectrometry by Karas, Michael, Bahr, Ute, Strupat, Kerstin, Hillenkamp, Franz, Tsarbopoulos, Anthony, Pramanik, Birendra N

“…The results of a study show that the extent of metastable fragmentation for proteins is strongly related to the matrix compound used in matrix-assisted laser…”
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Mass spectrometric studies of potent inhibitors of farnesyl protein transferase--detection of pentameric noncovalent complexes by Mirza, Urooj A, Chen, Guodong, Liu, Yan-Hui, Doll, Ronald J, Girijavallabhan, Viyyoor M, Ganguly, Ashit K, Pramanik, Birendra N

“…Farnesyl protein transferase (FPT) inhibition is an interesting and promising approach to noncytotoxic anticancer therapy. Research in this area has resulted…”
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Structure elucidation of everninomicin-6, a new oligosaccharide antibiotic, by chemical degradation and FAB-MS methods by Bartner, Peter, Pramanik, Birendra N., Saksena, Anil K., Liu, Yan-Hui, Das, Pradip R., Sarre, Olga, Ganguly, Ashit K.

“…The structural characterization of a new oligosaccharide antibiotic, Everninomicin-6 (EV-6), is described. Detailed fast-atom bombardment mass spectrometry…”
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Microwave enhanced Akabori reaction for peptide analysis by Bose, Ajay K, Ing, Yao Hain, Lavlinskaia, Nina, Sareen, Chaitanya, Pramanik, Birendra N, Bartner, Peter L, Liu, Yan-Hui, Heimark, Larry

“…The Akabori reaction, devised in 1952 for the identification of C-terminus amino acids, involves the heating of a linear peptide in the presence of anhydrous…”
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Enantioselective syntheses of carbocyclic ribavirin and its analogs: linear versus convergent approaches by Kuang, Rongze, Ganguly, Ashit K, Chan, Tze-Ming, Pramanik, Birendra N, Blythin, David J, McPhail, Andrew T, Saksena, Anil.K

“…The first enantioselective syntheses of carbocyclic ribavirin by both convergent and linear approaches are described. The linear approach from chiral…”
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