Search Results - "Prajapati, Indira"

Calculating the mass of subvisible protein particles with improved accuracy using microflow imaging data by Kalonia, Cavan, Kumru, Ozan S, Prajapati, Indira, Mathaes, Roman, Engert, Julia, Zhou, Shuxia, Middaugh, C Russell, Volkin, David B

“…Although formation of subvisible particles (1-100 μm) during manufacturing and/or storage is a major stability concern with protein therapeutics, particle…”
Get more information

A candidate multimodal functional genetic network for thermal adaptation by Wollenberg Valero, Katharina C, Pathak, Rachana, Prajapati, Indira, Bankston, Shannon, Thompson, Aprylle, Usher, Jaytriece, Isokpehi, Raphael D

“…Vertebrate ectotherms such as reptiles provide ideal organisms for the study of adaptation to environmental thermal change. Comparative genomic and exomic…”
Get full text

Near UV and Visible Light Photo-Degradation Mechanisms in Citrate Buffer: One-Electron Reduction of Peptide and Protein Disulfides promotes Oxidation and Cis/Trans Isomerization of Unsaturated Fatty Acids of Polysorbate 80 by Prajapati, Indira, Subelzu, Natalia, Zhang, Yilue, Wu, Yaqi, Schöneich, Christian

“…Citrate is a common buffer for slightly acidic pH ranges of protein formulations. In the presence of iron, citrate buffer undergoes photo-degradation induced…”
Get more information

Comparison of Polysorbate 80 Hydrolysis and Oxidation on the Aggregation of a Monoclonal Antibody by Larson, Nicholas R, Wei, Yangjie, Prajapati, Indira, Chakraborty, Aishik, Peters, Bjorn, Kalonia, Cavan, Hudak, Suzanne, Choudhary, Sureshkumar, Esfandiary, Reza, Dhar, Prajna, Schöneich, Christian, Middaugh, C Russell

“…Polysorbates are used ubiquitously in protein therapeutic drugs to help minimize adsorption to surfaces and aggregation. It has been recognized that…”
Get more information

Generation and Effect of Photo-Induced Radicals on Cross-Linking, Color Change, and Isomerization in Formulations of Peptides and Proteins by Prajapati, Indira

“…Protein biotherapeutics, especially monoclonal antibodies (mAbs), have been on the rise due to their high efficacy, potency, and low toxicity. They are mainly…”
Get full text

Visible Light Degradation of a Monoclonal Antibody in a High-Concentration Formulation: Characterization of a Tryptophan-Derived Chromophoric Photo-product by Comparison to Photo-degradation of N‑Acetyl‑l‑tryptophan Amide by Prajapati, Indira, Larson, Nicholas R, Choudhary, Sureshkumar, Kalonia, Cavan, Hudak, Suzanne, Esfandiary, Reza, Middaugh, C. Russell, Schöneich, Christian

“…We investigated the discoloration of a highly concentrated monoclonal antibody (mAbZ) in sodium acetate (NaAc) and histidine/lysine (His/Lys) buffer after…”
Get full text

Cis/Trans Isomerization of Unsaturated Fatty Acids in Polysorbate 80 During Light Exposure of a Monoclonal Antibody-Containing Formulation by Prajapati, Indira, Peters, Björn-Hendrik, Larson, Nicholas R, Wei, Yangjie, Choudhary, Sureshkumar, Kalonia, Cavan, Hudak, Suzanne, Esfandiary, Reza, Middaugh, C Russell, Schöneich, Christian

“…Light exposure of a monoclonal antibody formulation containing polysorbate 80 (PS80) leads to cis/trans isomerization of monounsaturated and polyunsaturated…”
Get more information

End-to-End Approach to Surfactant Selection, Risk Mitigation, and Control Strategies for Protein-Based Therapeutics by Morales, Annette Medina, Sreedhara, Alavattam, Buecheler, Jakob, Brosig, Sebastian, Chou, Danny, Christian, Twinkle, Das, Tapan, de Jong, Isabella, Fast, Jonas, Jagannathan, Bharat, Moussa, Ehab M., Nejadnik, M. Reza, Prajapati, Indira, Radwick, Allison, Rahman, Yusra, Singh, Shubhadra

“…A survey performed by the AAPS Drug Product Handling community revealed a general, mostly consensus, approach to the strategy for the selection of surfactant…”
Get full text

Correction: End-to-End Approach to Surfactant Selection, Risk Mitigation, and Control Strategies for Protein-Based Therapeutics by Morales, Annette Medina, Sreedhara, Alavattam, Buecheler, Jakob, Brosig, Sebastian, Chou, Danny, Christian, Twinkle, Das, Tapan, de Jong, Isabella, Fast, Jonas, Jagannathan, Bharat, Moussa, Ehab M., Nejadnik, M. Reza, Prajapati, Indira, Radwick, Allison, Rahman, Yusra, Singh, Shubhadra

Get full text

Electropolymerized eugenol: Evaluation as a protective film for oxygen sensing by Paul, David W., Prajapati, Indira, Reed, Michelle L.

“…Low oxygen levels in the brain are directly associated with stroke, and monitoring oxygen is essential to investigations of mechanisms in the brain that alter…”
Get full text