Search Results - "Praestgaard, J."

Privileged Molecules for Protein Binding Identified from NMR-Based Screening by Hajduk, Philip J, Bures, Mark, Praestgaard, Jens, Fesik, Stephen W

“…A statistical analysis of NMR-derived binding data on 11 protein targets was performed to identify molecular motifs that are preferred for protein binding. The…”
Get full text

Clustering of Hepatotoxins Based on Mechanism of Toxicity Using Gene Expression Profiles by Waring, Jeffrey F., Jolly, Robert A., Ciurlionis, Rita, Lum, Pek Yee, Praestgaard, Jens T., Morfitt, David C., Buratto, Bruno, Roberts, Chris, Schadt, Eric, Ulrich, Roger G.

“…Microarray technology, which allows one to quantitate the expression of thousands of genes simultaneously, has begun to have a major impact on many different…”
Get full text

841 THE EFFECT OF MILD TO MODERATE HEPATIC IMPAIRMENT ON THE PHARMACOKINETICS OF ALISPORIVIR (ALV) by Kovacs, S.J, Ke, J, Praestgaard, J, Barve, A, Zhang, J, Maietta, R, Sunkara, G, Stein, D.S

Get full text

622 SAFETY, AND TOLERABILITY OF NIM811, A NOVEL CYCLOPHILIN INHIBITOR FOR HCV, FOLLOWING SINGLE AND MULTIPLE ASCENDING DOSES IN HEALTHY VOLUNTEERS AND HCV-INFECTED PATIENTS by Ke, J, Lawitz, E, Rozier, R, Marbury, T, Nguyen, N, Serra, D, Dole, K, Praestgaard, J, Huang, M, Evans, T

Get full text

1045 SAFETY AND ANTIVIRAL EFFICACY OF 14 DAYS OF THE CYCOPHILIN INHIBITOR NIM811 IN COMBINATION WITH PEGYLATED INTERFERON α2a IN RELAPSED GENOTYPE 1 HCV INFECTED PATIENTS by Lawitz, E, Rouzier, R, Nguyen, T, Huang, M, Ke, J, Praestgaard, J, Serra, D, Koziel, M, Evans, T

Get full text

Exchangeably Weighted Bootstraps of the General Empirical Process by Praestgaard, Jens, Wellner, Jon A.

“…We consider an exchangeably weighted bootstrap of the general function-indexed empirical process. We find sufficient conditions on the bootstrap weights for…”
Get full text

VALIDITY AND RELIABILITY OF A BODY-WORN BIOMECHANICAL SENSOR PLATFORM FOR GAIT ANALYSIS by Argent, R., Bourke, A.K., Brom, M., Caulfield, B., Greene, B.R., Muaremi, A., Praestgaard, J., Scotti, C., Shabani, S., Vallejo, V., Walsh, L.

Get full text

Evaluation of the extent of nonlinearity in reportable range studies by Kroll, M H, Praestgaard, J, Michaliszyn, E, Styer, P E

“…To extend the polynomial method for evaluating linearity in 2 ways. First, we developed a screen to ascertain whether the data were precise enough to permit a…”
Get full text

CARTILAGE REGENERATION AFTER TREATMENT WITH LNA043, A NOVEL DISEASE-MODIFYING OSTEOARTHRITIS DRUG CANDIDATE: RESULTS FROM AN IMAGING-BASED PROOF-OF-CONCEPT TRIAL IN PATIENTS WITH FOCAL ARTICULAR CARTILAGE LESIONS IN THE KNEE by Saxer, F., Laurent, D., Scotti, C., Juras, V., Hacker, S., Cole, B., Pasa, L., Lehovec, R., Szomolanyi, P., Raithel, E., Praestgaard, J., Gamba, F.L., Jiménez, J.L., Ramos, D.S., Trattnig, S., Roubenoff, R., Schieker, M.

Get full text

984 Molecular profiles of drug response in HCV infected patients during the first 4 weeks of therapy for chronic hepatitis C virus with pegylated interferon containing regimens or albuferon by Balan, V., Nelson, D., Sulkowski, M., Rosati, M., Birse, C., Praestgaard, J., Osborn, B., Mesghali, H., Novello, L., Pickeral, O., Freimuth, W., Subramanian, G.

Get full text

Regeneration of hyaline cartilage in response to a single injection of LNA043, an ANGPTL3 mimetic, in the knee of patients with a focal cartilage defect by Laurent, D., Scotti, C., Schreiner, M., Neubauer, M., Muellner, T., Zaric, O., Juras, V., Szomolanyi, P., Goldhahn, J., Praestgaard, J., Gerwin, N., Roubenoff, R., Nehrer, S., Schieker, M., Trattnig, S.

Get full text

SMA THERAPIES II AND BIOMARKERS: P.261Safety and efficacy of the oral splice modulator branaplam in type 1 spinal muscular atrophy by Deconinck, N., Born, A., Baranello, G., Bertini, E., Jullien de Pommerol, H., Mancilla, B. Gomez, Goemans, N., Pingili, R., Praestgaard, J., Roubenoff, R., Schara, U.

Get full text

SMA THERAPIES II AND BIOMARKERS by Deconinck, N., Born, A., Baranello, G., Bertini, E., Jullien de Pommerol, H., Mancilla, B. Gomez, Goemans, N., Pingili, R., Praestgaard, J., Roubenoff, R., Schara, U.

Get full text

P.371 - Safety and efficacy findings in the first-in-human trial (FIH) of the oral splice modulator branaplam in type 1 spinal muscular atrophy (SMA): interim results by Charnas, L., Voltz, E., Pfister, C., Peters, T., Hartmann, A., Berghs-Clairmont, C., Praestgaard, J., de Raspide, M., Deconinck, N., Born, A., Baranello, G., Bertini, E., Schara, U., Goemans, N., Roubenoff, R.

Get full text

Safety and efficacy findings in the first-in-human trial (FIH) of the oral splice modulator branaplam in type 1 spinal muscular atrophy (SMA): interim results by Charnas, L., Voltz, E., Pfister, C., Peters, T., Hartmann, A., Berghs-Clairmont, C., Praestgaard, J., de Raspide, M., Deconinck, N., Born, A., Baranello, G., Bertini, E., Schara, U., Goemans, N., Roubenoff, R.

Get full text

Asymptotic Theory for Nonparametric Estimation of Survival Curves Under Order Restrictions by Praestgaard, Jens Thomas, Huang, Jian

“…We consider two problems in nonparametric survival analysis under the restriction of stochastic ordering. The first problem is that of estimating a survival…”
Get full text

P270 PROGRESSION OF KNEE OSTEOARTHRITIS (OA) MEASURED BY MRI IMAGING OF CARTILAGE LESIONS IN A COHORT OF PATIENTS IMAGED BEFORE AND 3 YEARS FOLLOWING ARTHROSCOPY by Praestgaard, J., Woodworth, T., Neumann, G., Mikulinsky, R., Brem, M., Yoshioka, H., Krajkovich, L., Wu, I., Katz, J.N., Losina, E., Fossel, A., Lang, P.

Get full text

The accuracy of laboratory measurements in clinical chemistry: a study of 11 routine chemistry analytes in the College of American Pathologists Chemistry Survey with fresh frozen serum, definitive methods, and reference methods by Ross, J W, Miller, W G, Myers, G L, Praestgaard, J

“…Better procedures are needed whereby national proficiency testing survey providers can assess and improve the accuracy of laboratory measurements in clinical…”
Get more information

Interval Mapping of Quantitative Trait Loci through Order-Restricted Inference by Nettleton, Dan, Praestgaard, Jens

“…An order-restricted version of the standard interval mapping procedure is introduced. The usual LOD scores (base 10 logs of likelihood ratios) used in interval…”
Get full text

Permutation and Bootstrap Kolmogorov-Smirnov Tests for the Equality of Two Distributions by PRAESTGAARD, J. T

“…We consider a generalized version of the two-sample Kolmogorov-Smirnov statistic which is calculated as the supremum distance, taken over a general class of…”
Get full text