Search Results - "Prado, Vânia F"

Acute lung injury is reduced by the α7nAChR agonist PNU‐282987 through changes in the macrophage profile by Pinheiro, Nathalia M., Santana, Fernanda P. R., Almeida, Rafael Ribeiro, Guerreiro, Marina, Martins, Milton A., Caperuto, Luciana C., Câmara, Niels O. S., Wensing, Lislaine A., Prado, Vânia F., Tibério, Iolanda F. L. C., Antônio M. Prado, Marco, Prado, Carla M.

“…Nicotinic α‐7 acetylcholine receptor (nAChRα7) is a critical regulator of cholinergic anti‐inflammatory actions in several diseases, including acute…”
Get full text

Acute Lung Injury in Cholinergic-Deficient Mice Supports Anti-Inflammatory Role of α7 Nicotinic Acetylcholine Receptor by Pinheiro, Nathalia M., Banzato, Rosana, Tibério, Iolanda, Prado, Marco A. M., Prado, Vânia F., Hamouda, Ayman K., Prado, Carla M.

“…(1) Background: The lung cholinergic pathway is important for controlling pulmonary inflammation in acute lung injury, a condition that is characterized by a…”
Get full text

Influence of β2-adrenergic selective agonist formoterol on the motor unit of a mouse model of a congenital myasthenic syndrome with complete VAChT deletion by Rossi, Leonardo, Mota, Bárbara I., Valadão, Priscila A.C., Magalhães-Gomes, Matheus P.S., Oliveira, Bruna S., Guatimosim, Silvia, Navegantes, Luiz C.C., Miranda, Aline S., Prado, Marco A.M., Prado, Vânia F., Guatimosim, Cristina

“…Congenital Myasthenic Syndromes (CMS) are a set of genetic diseases that affect the neuromuscular transmission causing muscular weakness. The standard…”
Get full text

Long-term endogenous acetylcholine deficiency potentiates pulmonary inflammation in a murine model of elastase-induced emphysema by Banzato, Rosana, Pinheiro, Nathalia M., Olivo, Clarice R., Santana, Fernanda R., Lopes, Fernanda D. T. Q. S., Caperuto, Luciana C., Câmara, Niels O., Martins, Milton A., Tibério, Iolanda F. L. C., Prado, Marco Antônio M., Prado, Vânia F., Prado, Carla M.

“…Acetylcholine (ACh), the neurotransmitter of the cholinergic system, regulates inflammation in several diseases including pulmonary diseases. ACh is also…”
Get full text

Increased Cholinergic Tone Causes Pre-synaptic Neuromuscular Degeneration and is Associated with Impaired Diaphragm Function by Magalhães-Gomes, Matheus P.S., Camargos, Wallace, Valadão, Priscila A.C., Garcias, Rubens S., Rodrigues, Hermann A., Andrade, Jéssica N., Teixeira, Vanessa P., Naves, Lígia A., Cavalcante, Walter L.G., Gallaci, Marcia, Guatimosim, Silvia, Prado, Vânia F., Prado, Marco A.M., Guatimosim, Cristina

“…•Increased VAChT expression augments post-synaptic response.•Hypercholinergic mice show endocytosis impairment and endplates degeneration.•Mice with increased…”
Get full text

Alpha-7 Nicotinic Receptor Agonist Protects Mice Against Pulmonary Emphysema Induced by Elastase by Banzato, Rosana, Pinheiro-Menegasso, Nathalia M., Novelli, Fernanda Paula Roncon Santana, Olivo, Clarice R., Taguchi, Laura, de Oliveira Santos, Stheffany, Fukuzaki, Silvia, Teodoro, Walcy Paganelli Rosolia, Lopes, Fernanda D. T. Q. S., Tibério, Iolanda F. L. C., de Toledo-Arruda, Alessandra Choqueta, Prado, Marco Antônio M., Prado, Vânia F., Prado, Carla M.

“…Pulmonary emphysema is a primary component of chronic obstructive pulmonary disease (COPD), a life-threatening disorder characterized by lung inflammation and…”
Get full text

Vesicular acetylcholine transport deficiency potentiates some inflammatory responses induced by diesel exhaust particles by Santana, Fernanda P.R., Pinheiro, Nathalia M., Bittencourt-Mernak, Márcia I., Perini, Adenir, Yoshizaki, Kelly, Macchione, Mariângela, Saldiva, Paulo H.N., Martins, Milton A., Tibério, Iolanda F.L.C., Prado, Marco Antônio M., Prado, Vânia F., Prado, Carla M.

“…Endogenous acetylcholine (ACh), which depends of the levels of vesicular ACh transport (VAChT) to be released, is the central mediator of the cholinergic…”
Get full text

Reduced Vesicular Acetylcholine Transporter favors antidepressant behaviors and modulates serotonin and dopamine in female mouse brain by Pádua-Reis, Marina, Aquino, Nayara S., Oliveira, Vinícius E.M., Szawka, Raphael E., Prado, Marco A.M., Prado, Vânia F., Pereira, Grace S.

“…•The cholinergic hypothesis of depression is revisited through a transgenic animal with hipocholinergic function.•VAChT knockdown mouse exhibits less…”
Get full text

Lung Edema and Mortality Induced by Intestinal Ischemia and Reperfusion Is Regulated by VAChT Levels in Female Mice by Santana, Fernanda P. R., Ricardo-da-Silva, Fernanda Y., Fantozzi, Evelyn T., Pinheiro, Nathália M., Tibério, Iolanda F. L. C., Moreira, Luiz Felipe Pinho, Prado, Marco Antônio M., Prado, Vânia F., Tavares-de-Lima, Wothan, Prado, Carla Máximo, Breithaupt-Faloppa, Ana Cristina

“…Acute lung injury induced by intestinal ischemia/reperfusion (I/R) is a relevant clinical condition. Acetylcholine (ACh) and the α7 nicotinic ACh receptor…”
Get full text

Fast and slow-twitching muscles are differentially affected by reduced cholinergic transmission in mice deficient for VAChT: A mouse model for congenital myasthenia by Magalhães-Gomes, Matheus P.S., Motta-Santos, Daisy, Schetino, Luana P.L., Andrade, Jéssica N., Bastos, Cristiane P., Guimarães, Diogo A.S., Vaughan, Sydney K., Martinelli, Patrícia M., Guatimosim, Silvia, Pereira, Grace S., Coimbra, Candido C., Prado, Vânia F., Prado, Marco A.M., Valdez, Gregorio, Guatimosim, Cristina

“…Congenital myasthenic syndromes (CMS) result from reduced cholinergic transmission at neuromuscular junctions (NMJs). While the etiology of CMS varies, the…”
Get full text

Estradiol effect on short-term object memory under hypocholinergic condition by Pereira, Luciana M., Guimarães, Isabella M., Oliveira, Vinícius E.M., Bastos, Cristiane P., Ribeiro, Fabíola M., Prado, Vânia F., Prado, Marco A.M., Pereira, Grace S.

“…•Estradiol recovers short-term object recognition memory deficit of VAChT KD male mice and OVX VAChT KD female mice.•Hippocampal ERα activation recovers memory…”
Get full text

Reduced expression of the vesicular acetylcholine transporter and neurotransmitter content affects synaptic vesicle distribution and shape in mouse neuromuscular junction by Rodrigues, Hermann A, Fonseca, Matheus de C, Camargo, Wallace L, Lima, Patrícia M A, Martinelli, Patrícia M, Naves, Lígia A, Prado, Vânia F, Prado, Marco A M, Guatimosim, Cristina

“…In vertebrates, nerve muscle communication is mediated by the release of the neurotransmitter acetylcholine packed inside synaptic vesicles by a specific…”
Get full text

Vesicular acetylcholine transporter knock-down mice show sexual dimorphism on memory by Capettini, Suellem B, Moraes, Márcio F.D, Prado, Vânia F, Prado, Marco A.M, Pereira, Grace S

“…Research highlights ► VAChT mutant mice present sexual dimorphism on memory. ► Object recognition memory is differentially modulated by cholinergic system. ►…”
Get full text

Antiarrhythmogenic effects of a neurotoxin from the spider Phoneutria nigriventer by Almeida, Alvair P., Andrade, Alexandre B., Ferreira, Anderson J., Pires, Andrea C.G., Damasceno, Denis D., Alves, Márcia N.M., Gomes, Enéas R.M., Kushmerick, Christopher, Lima, Ricardo F., Prado, Marco Antônio M., Prado, Vânia F., Richardson, Michael, Cordeiro, Marta N., Guatimosim, Silvia, Gomez, MarcusVinícius

“…In this study, we evaluated the effects of PhKv, a 4584 Da peptide isolated from the spider Phoneutria nigriventer venom, in the isolated rat heart and in…”
Get full text

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases by Lackie, Rachel E, Maciejewski, Andrzej, Ostapchenko, Valeriy G, Marques-Lopes, Jose, Choy, Wing-Yiu, Duennwald, Martin L, Prado, Vania F, Prado, Marco A M

“…The accumulation of misfolded proteins in the human brain is one of the critical features of many neurodegenerative diseases, including Alzheimer's disease…”
Get full text

Regulation of cholinergic activity by the vesicular acetylcholine transporter by Prado, Vania F, Roy, Ashbeel, Kolisnyk, Benjamin, Gros, Robert, Prado, Marco A M

“…Acetylcholine, the first chemical to be identified as a neurotransmitter, is packed in synaptic vesicles by the activity of VAChT (vesicular acetylcholine…”
Get more information

Vesicular acetylcholine transporter knock-down mice are more susceptible to pilocarpine induced status epilepticus by Guidine, Patrícia A.M., Rezende, Gustavo H.S., Queiroz, Cláudio M.T., Mello, Luiz Eugênio, Prado, Vânia F., Prado, Marco A.M., Pereira, Grace S., Moraes, Márcio F.D.

“…The pilocarpine (PILO) animal model of Temporal Lobe Epilepsy (TLE) portrays the most common changes in hippocampal circuitry found in human TLE. The acute…”
Get full text

Multimodal gradients of basal forebrain connectivity across the neocortex by Chakraborty, Sudesna, Haast, Roy A. M., Onuska, Kate M., Kanel, Prabesh, Prado, Marco A. M., Prado, Vania F., Khan, Ali R., Schmitz, Taylor W.

“…Cortical cholinergic projections originate from subregions of the basal forebrain (BF). To examine its organization in humans, we computed multimodal gradients…”
Get full text

Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues by Skirzewski, Miguel, Princz-Lebel, Oren, German-Castelan, Liliana, Crooks, Alycia M., Kim, Gerard Kyungwook, Tarnow, Sophie Henke, Reichelt, Amy, Memar, Sara, Palmer, Daniel, Li, Yulong, Jane Rylett, R., Saksida, Lisa M., Prado, Vania F., Prado, Marco A. M., Bussey, Timothy J.

“…The ability to learn Pavlovian associations from environmental cues predicting positive outcomes is critical for survival, motivating adaptive behaviours. This…”
Get full text

Dissociable cognitive impairments in two strains of transgenic Alzheimer’s disease mice revealed by a battery of object-based tests by Creighton, Samantha D., Mendell, Ari L., Palmer, Daniel, Kalisch, Bettina E., MacLusky, Neil J., Prado, Vania F., Prado, Marco A. M., Winters, Boyer D.

“…Object recognition tasks detect cognitive deficits in transgenic Alzheimer’s disease (AD) mouse models. Object recognition, however, is not a unitary process,…”
Get full text