Search Results - "Pradhan, Saurabh J."

Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation by Sako, Keisuke, Pradhan, Saurabh J., Barone, Vanessa, Inglés-Prieto, Álvaro, Müller, Patrick, Ruprecht, Verena, Čapek, Daniel, Galande, Sanjeev, Janovjak, Harald, Heisenberg, Carl-Philipp

“…During metazoan development, the temporal pattern of morphogen signaling is critical for organizing cell fates in space and time. Yet, tools for temporally…”
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Regulation of chromatin accessibility and gene expression in the developing hippocampal primordium by LIM-HD transcription factor LHX2 by Suresh, Varun, Muralidharan, Bhavana, Pradhan, Saurabh J, Bose, Mahima, D'Souza, Leora, Parichha, Arpan, Reddy, Puli Chandramouli, Galande, Sanjeev, Tole, Shubha

“…In the mammalian cerebral cortex, the hippocampal primordium (Hcp) occupies a discrete position in the dorsal telencephalic neuroepithelium adjacent to the…”
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Chromatin organizer SATB1 as a novel molecular target for cancer therapy by Mir, Rafeeq, Pradhan, Saurabh J, Galande, Sanjeev

“…Cancer progression and metastasis involve series of alterations in the expression of multitude of genes. The structure and organization of chromatin play an…”
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Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis by Pradhan, Saurabh J., Reddy, Puli Chandramouli, Smutny, Michael, Sharma, Ankita, Sako, Keisuke, Oak, Meghana S., Shah, Rini, Pal, Mrinmoy, Deshpande, Ojas, Dsilva, Greg, Tang, Yin, Mishra, Rakesh, Deshpande, Girish, Giraldez, Antonio J., Sonawane, Mahendra, Heisenberg, Carl-Philipp, Galande, Sanjeev

“…Zygotic genome activation (ZGA) initiates regionalized transcription underlying distinct cellular identities. ZGA is dependent upon dynamic chromatin…”
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Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron-Glia Cell-Fate Switch in the Developing Hippocampus by Muralidharan, Bhavana, Keruzore, Marc, Pradhan, Saurabh J, Roy, Basabdatta, Shetty, Ashwin S, Kinare, Veena, D'Souza, Leora, Maheshwari, Upasana, Karmodiya, Krishanpal, Suresh, Agasthya, Galande, Sanjeev, Bellefroid, Eric J, Tole, Shubha

“…Regulation of the neuron-glia cell-fate switch is a critical step in the development of the CNS. Previously, we demonstrated that Lhx2 is a necessary and…”
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Regulation of Transcription Factor SP1 by the β-Catenin Destruction Complex Modulates Wnt Response by Mir, Rafeeq, Sharma, Ankita, Pradhan, Saurabh J., Galande, Sanjeev

“…The ubiquitous transcription factor specificity protein 1 (SP1) is heavily modified posttranslationally. These modifications are critical for switching its…”
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A Micro-evolutionary Change in Target Binding Sites as a Key Determinant of Ultrabithorax Function in Drosophila by Khan, Soumen, Pradhan, Saurabh J., Giraud, Guillaume, Bleicher, Françoise, Paul, Rachel, Merabet, Samir, Shashidhara, L. S.

“…Hox genes encode Homeodomain-containing transcription factors, which specify segmental identities along the anterior–posterior axis. Functional changes in Hox…”
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Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero by Seong, Jinwoo, Frias-Aldeguer, Javier, Holzmann, Viktoria, Kagawa, Harunobu, Sestini, Giovanni, Heidari Khoei, Heidar, Scholte Op Reimer, Yvonne, Kip, Maarten, Pradhan, Saurabh J., Verwegen, Lucas, Vivié, Judith, Li, Linfeng, Alemany, Anna, Korving, Jeroen, Darmis, Frank, van Oudenaarden, Alexander, ten Berge, Derk, Geijsen, Niels, Rivron, Nicolas C.

“…The embryo instructs the allocation of cell states to spatially regulate functions. In the blastocyst, patterning of trophoblast (TR) cells ensures successful…”
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An Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling Determines Cell Fate by Barone, Vanessa, Lang, Moritz, Krens, S.F. Gabriel, Pradhan, Saurabh J., Shamipour, Shayan, Sako, Keisuke, Sikora, Mateusz, Guet, Călin C., Heisenberg, Carl-Philipp

“…Cell-cell contact formation constitutes an essential step in evolution, leading to the differentiation of specialized cell types. However, remarkably little is…”
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LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11 by Muralidharan, Bhavana, Khatri, Zeba, Maheshwari, Upasana, Gupta, Ritika, Roy, Basabdatta, Pradhan, Saurabh J, Karmodiya, Krishanpal, Padmanabhan, Hari, Shetty, Ashwin S, Balaji, Chinthapalli, Kolthur-Seetharam, Ullas, Macklis, Jeffrey D, Galande, Sanjeev, Tole, Shubha

“…In the developing cerebral cortex, sequential transcriptional programs take neuroepithelial cells from proliferating progenitors to differentiated neurons with…”
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A comprehensive epigenome map of Plasmodium falciparum reveals unique mechanisms of transcriptional regulation and identifies H3K36me2 as a global mark of gene suppression by Karmodiya, Krishanpal, Pradhan, Saurabh J, Joshi, Bhagyashree, Jangid, Rahul, Reddy, Puli Chandramouli, Galande, Sanjeev

“…Role of epigenetic mechanisms towards regulation of the complex life cycle/pathogenesis of Plasmodium falciparum, the causative agent of malaria, has been…”
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Camello, a novel family of Histone Acetyltransferases that acetylate histone H4 and is essential for zebrafish development by Karmodiya, Krishanpal, Anamika, Krishanpal, Muley, Vijaykumar, Pradhan, Saurabh J., Bhide, Yoshita, Galande, Sanjeev

“…In this study, we have investigated genome-wide occurrence of Histone Acetyltransferases (HATs) in genomes of Mus musculus and Danio rerio on the basis of…”
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Origin of RNA Polymerase II pause in eumetazoans: Insights from Hydra by Reddy, Puli Chandramouli, Pradhan, Saurabh J, Karmodiya, Krishanpal, Galande, Sanjeev

“…Multicellular organisms have evolved sophisticated mechanisms for responding to various developmental, environmental and physical stimuli by regulating…”
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Correlation of cell‐surface CD8 levels with function, phenotype and transcriptome of naive CD8 T cells by Balyan, Renu, Gund, Rupali, Chawla, Amanpreet Singh, Khare, Satyajeet P., Pradhan, Saurabh J., Rane, Sanket, Galande, Sanjeev, Durdik, Jeannine Marie, George, Anna, Bal, Vineeta, Rath, Satyajit

“…We have previously demonstrated co‐receptor level‐associated functional heterogeneity in apparently homogeneous naive peripheral CD4 T cells, dependent on…”
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Molecular signature of an ancient organizer regulated by Wnt/β-catenin signalling during primary body axis patterning in Hydra by Reddy, Puli Chandramouli, Gungi, Akhila, Ubhe, Suyog, Pradhan, Saurabh J., Kolte, Amol, Galande, Sanjeev

“…Wnt/β-catenin signalling has been shown to play a critical role during head organizer formation in Hydra . Here, we characterized the Wnt signalling regulatory…”
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Comparative sequence analyses of genome and transcriptome reveal novel transcripts and variants in the Asian elephant Elephas maximus by Reddy, Puli Chandramouli, Sinha, Ishani, Kelkar, Ashwin, Habib, Farhat, Pradhan, Saurabh J, Sukumar, Raman, Galande, Sanjeev

“…The Asian elephant Elephas maximus and the African elephant Loxodonta africana that diverged 5–7 million years ago exhibit differences in their physiology,…”
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LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11 by Muralidharan, Bhavana, Khatri, Zeba, Maheshwari, Upasana, Gupta, Ritika, Roy, Basabdatta, Pradhan, Saurabh J., Karmodiya, Krishanpal, Padmanabhan, Hari, Shetty, Ashwin S., Balaji, Chinthapalli, Kolthur-Seetharam, Ullas, Macklis, Jeffrey D., Galande, Sanjeev, Tole, Shubha

“…In the developing cerebral cortex, sequential transcriptional programs take neuroepithelial cells from proliferating progenitors to differentiated neurons with…”
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Quercetin and sulforaphane in combination suppress the progression of melanoma through the down-regulation of matrix metalloproteinase-9 by PRADHAN, SAURABH J, MISHRA, ROSALIN, SHARMA, PRIYANKA, KUNDU, GOPAL C

“…Malignant melanoma is one of the most common types of cancer in the US and worldwide. The epidemiological data suggest that dietary modification may reduce the…”
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Correlation of cell‐surface CD 8 levels with function, phenotype and transcriptome of naive CD 8 T cells by Balyan, Renu, Gund, Rupali, Chawla, Amanpreet Singh, Khare, Satyajeet P., Pradhan, Saurabh J., Rane, Sanket, Galande, Sanjeev, Durdik, Jeannine Marie, George, Anna, Bal, Vineeta, Rath, Satyajit

“…Abstract We have previously demonstrated co‐receptor level‐associated functional heterogeneity in apparently homogeneous naive peripheral CD 4 T cells,…”
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PRDM16 co-operates with LHX2 to shape the human brain by Suresh, Varun, Bhattacharya, Bidisha, Tshuva, Rami Yair, Danan Gotthold, Miri, Olender, Tsviya, Bose, Mahima, Pradhan, Saurabh J, Zeev, Bruria Ben, Smith, Richard Scott, Tole, Shubha, Galande, Sanjeev, Harwell, Corey C, Baizabal, José-Manuel, Reiner, Orly

“…PRDM16 is a dynamic transcriptional regulator of various stem cell niches, including adipocytic, hematopoietic, cardiac progenitors, and neural stem cells…”
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