Search Results - "Pradelli, Ludivine A."
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Combination of glycolysis inhibition with chemotherapy results in an antitumor immune response
Published in Proceedings of the National Academy of Sciences - PNAS (04-12-2012)“…Most DNA-damaging agents are weak inducers of an anticancer immune response. Increased glycolysis is one of the best-described hallmarks of tumor cells;…”
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Mitochondrial control of caspase-dependent and -independent cell death
Published in Cellular and molecular life sciences : CMLS (01-05-2010)“…Mitochondria control whether a cell lives or dies. The role mitochondria play in deciding the fate of a cell was first identified in the mid-1990s, because…”
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The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice
Published in The EMBO journal (19-08-2009)“…We showed previously that Lyn is a substrate for caspases, a family of cysteine proteases, involved in the regulation of apoptosis and inflammation. Here, we…”
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PPARγ contributes to PKM2 and HK2 expression in fatty liver
Published in Nature communications (14-02-2012)“…Rapidly proliferating cells promote glycolysis in aerobic conditions, to increase growth rate. Expression of specific glycolytic enzymes, namely pyruvate…”
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Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice
Published in Blood (03-10-2013)“…Caloric restriction (CR) is proposed to decrease tumorigenesis through a variety of mechanisms including effects on glycolysis. However, the understanding of…”
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E2F transcription factor-1 deficiency reduces pathophysiology in the mouse model of Duchenne muscular dystrophy through increased muscle oxidative metabolism
Published in Human molecular genetics (01-09-2012)“…E2F1 deletion leads to increased mitochondrial number and function, increased body temperature in response to cold and increased resistance to fatigue with…”
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Modulation of Caspase-Independent Cell Death Leads to Resensitization of Imatinib Mesylate―Resistant Cells
Published in Cancer research (Chicago, Ill.) (01-04-2009)“…Imatinib mesylate is widely used for the treatment of patients with chronic myelogenous leukemia (CML). This compound is very efficient in killing…”
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The human MSH5 (MutSHomolog 5) protein localizes to mitochondria and protects the mitochondrial genome from oxidative damage
Published in Mitochondrion (01-11-2012)“…MutS homologs play a central role in maintaining genetic stability. We show that MSH5 (MutSHomolog 5) is localized into the mitochondria of germ and somatic…”
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PPAR[gamma] contributes to PKM2 and HK2 expression in fatty liver
Published in Nature communications (01-02-2012)“…Rapidly proliferating cells promote glycolysis in aerobic conditions, to increase growth rate. Expression of specific glycolytic enzymes, namely pyruvate…”
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Journal Article