Search Results - "Pradat, Pierre‐François"

Time for optimism in amyotrophic lateral sclerosis by Corcia, Philippe, Lunetta, Christian, Vourc'h, Patrick, Pradat, Pierre‐François, Blasco, Hélène

“…Background and purpose Amyotrophic lateral sclerosis (ALS) is among the most common motor neuron diseases in adults. Nevertheless, ALS remains fatal, despite…”
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The changing landscape of motor neuron disease imaging: the transition from descriptive studies to precision clinical tools by Bede, Peter, Querin, Giorgia, Pradat, Pierre-François

“…Neuroimaging in motor neuron disease (MND) has traditionally been seen as an academic tool with limited direct relevance to individualized patient care. This…”
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Energy metabolism in amyotrophic lateral sclerosis by Dupuis, Luc, Dr, Pradat, Pierre-François, MD, Ludolph, Albert C, Prof, Loeffler, Jean-Philippe, PhD

“…Summary Amyotrophic lateral sclerosis (ALS) is characterised by the progressive degeneration of upper and lower motor neurons. Besides motor neuron…”
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Presymptomatic spinal cord pathology in c9orf72 mutation carriers: A longitudinal neuroimaging study by Querin, Giorgia, Bede, Peter, El Mendili, Mohamed Mounir, Li, Menghan, Pélégrini‐Issac, Mélanie, Rinaldi, Daisy, Catala, Martin, Saracino, Dario, Salachas, François, Camuzat, Agnes, Marchand‐Pauvert, Véronique, Cohen‐Adad, Julien, Colliot, Olivier, Le Ber, Isabelle, Pradat, Pierre‐François

“…Objective C9orf72 hexanucleotide repeats expansions account for almost half of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)…”
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Exceptional euthanasia: a theoretical construct or medical necessity? by Pradat, Pierre-François, Piazza, Sara, Fourcade, Claire, Perrigault, Pierre-François

“…In France, the medical community is deeply engaged in a pivotal debate surrounding a draft bill that is set to be presented to the Presidential Cabinet for…”
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Split-hand and split-limb phenomena in amyotrophic lateral sclerosis: pathophysiology, electrophysiology and clinical manifestations by Corcia, Philippe, Bede, Peter, Pradat, Pierre-François, Couratier, Philippe, Vucic, Steve, de Carvalho, Mamede

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting the upper and lower motor neurons. A key clinical feature of ALS is…”
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Radiation-induced neuropathy in cancer survivors by Delanian, Sylvie, Lefaix, Jean-Louis, Pradat, Pierre-François

“…Abstract Radiation-induced peripheral neuropathy is a chronic handicap, frightening because progressive and usually irreversible, usually appearing several…”
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Machine Learning in Amyotrophic Lateral Sclerosis: Achievements, Pitfalls, and Future Directions by Grollemund, Vincent, Pradat, Pierre-François, Querin, Giorgia, Delbot, François, Le Chat, Gaétan, Pradat-Peyre, Jean-François, Bede, Peter

“…Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive neurodegenerative condition with limited therapeutic options at present. Survival from…”
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Spinal Cord Imaging in Amyotrophic Lateral Sclerosis: Historical Concepts-Novel Techniques by El Mendili, Mohamed Mounir, Querin, Giorgia, Bede, Peter, Pradat, Pierre-François

“…Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease with no effective disease modifying therapies at present. Spinal cord…”
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Multimodal spinal cord MRI offers accurate diagnostic classification in ALS by Querin, Giorgia, El Mendili, Mohamed-Mounir, Bede, Peter, Delphine, Sébastien, Lenglet, Timothée, Marchand-Pauvert, Véronique, Pradat, Pierre-François

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Absence of hyperexcitability of spinal motoneurons in patients with amyotrophic lateral sclerosis by Marchand‐Pauvert, Véronique, Peyre, Iseline, Lackmy‐Vallee, Alexandra, Querin, Giorgia, Bede, Peter, Lacomblez, Lucette, Debs, Rabab, Pradat, Pierre‐François

“…Key points •Amyotrophic lateral sclerosis (ALS) motoneurons become hypoexcitable with disease progression in experimental models, raising questions about the…”
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Status of ALS Treatment, Insights into Therapeutic Challenges and Dilemmas by Khamaysa, Mohammed, Pradat, Pierre-François

“…Amyotrophic lateral sclerosis (ALS) is an extremely heterogeneous disease of motor neurons that eventually leads to death. Despite impressive advances in…”
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A pharmaco-metabolomics approach in a clinical trial of ALS: Identification of predictive markers of progression by Blasco, Hélène, Patin, Franck, Descat, Amandine, Garçon, Guillaume, Corcia, Philippe, Gelé, Patrick, Lenglet, Timothée, Bede, Peter, Meininger, Vincent, Devos, David, Gossens, Jean François, Pradat, Pierre-François

“…There is an urgent and unmet need for accurate biomarkers in Amyotrophic Lateral Sclerosis. A pharmaco-metabolomics study was conducted using plasma samples…”
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Development and validation of a 1-year survival prognosis estimation model for Amyotrophic Lateral Sclerosis using manifold learning algorithm UMAP by Grollemund, Vincent, Chat, Gaétan Le, Secchi-Buhour, Marie-Sonia, Delbot, François, Pradat-Peyre, Jean-François, Bede, Peter, Pradat, Pierre-François

“…Amyotrophic Lateral Sclerosis (ALS) is an inexorably progressive neurodegenerative condition with no effective disease modifying therapies. The development and…”
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A retrospective analysis of all‐cause and cause‐specific mortality rates in French male professional footballers by Orhant, Emmanuel, Carling, Christopher, Chapellier, Jean‐François, Marchand, Jean‐Luc, Pradat, Pierre‐François, Elbaz, Alexis, Maniez, Sandrine, Moisan, Frédéric, Rochcongar, Pierre

“…This study retrospectively compared all‐cause and cause‐specific mortality in French male professional football players with data from France's national…”
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Transient increase in recurrent inhibition in amyotrophic lateral sclerosis as a putative protection from neurodegeneration by Sangari, Sina, Peyre, Iseline, Lackmy‐Vallée, Alexandra, Bayen, Eléonore, Pradat, Pierre‐François, Marchand‐Pauvert, Véronique

“…Aim Adaptive mechanisms in spinal circuits are likely involved in homeostatic responses to maintain motor output in amyotrophic lateral sclerosis. Given the…”
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Interaction of sex and onset site on the disease trajectory of amyotrophic lateral sclerosis by Ortholand, Juliette, Pradat, Pierre-François, Tezenas du Montcel, Sophie, Durrleman, Stanley

“…Background Studies showed the impact of sex and onset site (spinal or bulbar) on disease onset and survival in ALS. However, they mainly result from…”
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Environmental risk factors for amyotrophic lateral sclerosis: a case-control study in Canada and France by Beaudin, Marie, Salachas, François, Pradat, Pierre-François, Dupré, Nicolas

“…Objective: To evaluate the association between amyotrophic lateral sclerosis (ALS) and potential environmental risk factors, especially head traumas and…”
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Extrapyramidal deficits in ALS: a combined biomechanical and neuroimaging study by Feron, Maryse, Couillandre, Annabelle, Mseddi, Eya, Termoz, Nicolas, Abidi, Malek, Bardinet, Eric, Delgadillo, Daniel, Lenglet, Timothée, Querin, Giorgia, Welter, Marie-Laure, Le Forestier, Nadine, Salachas, François, Bruneteau, Gaelle, del Mar Amador, Maria, Debs, Rabab, Lacomblez, Lucette, Meininger, Vincent, Pélégrini-Issac, Mélanie, Bede, Peter, Pradat, Pierre-François, de Marco, Giovanni

“…Introduction Extrapyramidal deficits are poorly characterised in amyotrophic lateral sclerosis (ALS) despite their contribution to functional disability,…”
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Muscle histone deacetylase 4 upregulation in amyotrophic lateral sclerosis: potential role in reinnervation ability and disease progression by BRUNETEAU, Gaëlle, SIMONET, Thomas, HELL-REMY, Caroline, SALACHAS, François, PRADAT, Pierre-François, FOURNIER, Emmanuel, LACOMBLEZ, Lucette, KOENIG, Jeanine, ROMERO, Norma Beatriz, FONTAINE, Bertrand, MEININGER, Vincent, SCHAEFFER, Laurent, BAUCHE, Stéphanie, HANTAÏ, Daniel, MANDJEE, Nathalie, MALFATTI, Edoardo, GIRARD, Emmanuelle, TANGUY, Marie-Laure, BEHIN, Anthony, KHIAMI, Frédéric, SARIALI, Elhadi

“…Amyotrophic lateral sclerosis is a typically rapidly progressive neurodegenerative disorder affecting motor neurons leading to progressive muscle paralysis and…”
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