Search Results - "Prabhu, Sathyen A"

Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies by Akl, Mohamed R, Nagpal, Poonam, Ayoub, Nehad M, Tai, Betty, Prabhu, Sathyen A, Capac, Catherine M, Gliksman, Matthew, Goy, Andre, Suh, K Stephen

“…Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology. Mammalian FGF family members participate in multiple signaling pathways by…”
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The MNK1/2-eIF4E Axis as a Potential Therapeutic Target in Melanoma by Prabhu, Sathyen A, Moussa, Omar, Miller, Jr, Wilson H, Del Rincón, Sonia V

“…Melanoma is a type of skin cancer that originates in the pigment-producing cells of the body known as melanocytes. Most genetic aberrations in melanoma result…”
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Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas by Lue, Jennifer K, Prabhu, Sathyen A, Liu, Yuxuan, Gonzalez, Yulissa, Verma, Akanksha, Mundi, Prabhjot S, Abshiru, Nebiyu, Camarillo, Jeannie M, Mehta, Swasti, Chen, Emily I, Qiao, Changhong, Nandakumar, Renu, Cremers, Serge, Kelleher, Neil L, Elemento, Olivier, Amengual, Jennifer E

“…Both gain-of-function enhancer of zeste homolog 2 (EZH2) mutations and inactivating histone acetyltransferases mutations, such as CREBBP and EP300, have been…”
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Molecular and clinical profiles of syndecan-1 in solid and hematological cancer for prognosis and precision medicine by Akl, Mohamed R, Nagpal, Poonam, Ayoub, Nehad M, Prabhu, Sathyen A, Gliksman, Matthew, Tai, Betty, Hatipoglu, Ahmet, Goy, Andre, Suh, K Stephen

“…Syndecan-1 (SDC1, CD138) is a key cell surface adhesion molecule essential for maintaining cell morphology and interaction with the surrounding…”
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MNK1 signaling induces an ANGPTL4-mediated gene signature to drive melanoma progression by Yang, William, Khoury, Elie, Guo, Qianyu, Prabhu, Sathyen A., Emond, Audrey, Huang, Fan, Gonçalves, Christophe, Zhan, Yao, Plourde, Dany, Nichol, Jessica N., Dahabieh, Michael S., Miller Jr, Wilson H., del Rincón, Sonia Victoria

“…The BRAF V600E mutation occurs in more than 50% of cutaneous melanomas, and results in the constitutive activation of the mitogen-activated protein kinases…”
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Mechanisms of Acquired Drug Resistance to the HDAC6 Selective Inhibitor Ricolinostat Reveals Rational Drug-Drug Combination with Ibrutinib by Amengual, Jennifer E, Prabhu, Sathyen A, Lombardo, Maximilian, Zullo, Kelly, Johannet, Paul M, Gonzalez, Yulissa, Scotto, Luigi, Serrano, Xavier Jirau, Wei, Ying, Duong, Jimmy, Nandakumar, Renu, Cremers, Serge, Verma, Akanksha, Elemento, Olivier, O'Connor, Owen A

“…Pan-class I/II histone deacetylase (HDAC) inhibitors are effective treatments for select lymphomas. Isoform-selective HDAC inhibitors are emerging as…”
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Inhibition of the MNK1/2-eIF4E Axis Augments Palbociclib-Mediated Antitumor Activity in Melanoma and Breast Cancer by Prabhu, Sathyen A, Moussa, Omar, Gonçalves, Christophe, LaPierre, Judith H, Chou, Hsiang, Huang, Fan, Richard, Vincent R, Ferruzo, Pault Y M, Guettler, Elizabeth M, Soria-Bretones, Isabel, Kirby, Laura, Gagnon, Natascha, Su, Jie, Silvester, Jennifer, Krisna, Sai Sakktee, Rose, April A N, Sheppard, Karen E, Cescon, David W, Mallette, Frédérick A, Zahedi, Rene P, Borchers, Christoph H, Del Rincon, Sonia V, Miller, Wilson H

“…Aberrant cell-cycle progression is characteristic of melanoma, and CDK4/6 inhibitors, such as palbociclib, are currently being tested for efficacy in this…”
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Epigenetic Targeting with EZH2 and HDAC Inhibitors Is Synergistic in EZH2 Deregulated Lymphomas by Lue, Jennifer Kimberly, Prabhu, Sathyen A, Liu, Yuxuan, O'Connor, Owen A., Amengual, Jennifer E

“…EZH2 is critical in a process known as the Germinal Center (GC) reaction during which B-cells undergo somatic hypermutation and isotype switching in order to…”
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Mechanisms of Acquired Drug Resistance to the Isoform Selective HDAC6 Inhibitor Ricolinostat Reveals Markedly Upregulated Elements of the BTK Pathway Revealing Rational Drug : Drug Combinations by Amengual, Jennifer E, Lombardo, Maximilian, Zullo, Kelly M, Johannet, Paul M., Prabhu, Sathyen A, Yulissa, Gonzalez, Scotto, Luigi, Wei, Ying, Duong, Jimmy, O'Connor, Owen A.

“…HDAC6 is cytoplasmic with non-histone substrates and binds poly-ubiquinated misfolded proteins facilitating transport to the aggresome for…”
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High Expression of FGF2/SDC1 Signaling Contributes to Poor Clinical Outcome in Hodgkin Lymphoma Patients and SDC1 siRNA Suppresses Proliferation, Migration, and Invasion in Hodgkin Lymphoma Cells by Nagpal, Poonam, Goy, Andre, Gangadharan, Anju, Akl, Mohamed R., Voznenko, Ivan, Soni, Mihir, Tai, Betty, Cousins, Tasheka, Feldman, Tatyana A, Prabhu, Sathyen A., Ally, Amanda, Anderson-Crannage, Morgan, Leslie, Lori A., K., Lady, Kanwal, Fareeha, Tomiyama, Tatsunari, Khurram, Aliya, Capac, Catherine M., Gliksman, Matthew, Helios, Despina, Descalzi-Montoya, Dante B., Pecora, Andrew L., Suh, K. Stephen

“…Our recent studies have shown that Fibroblast Growth Factor-2 (FGF2) and Syndecan-1 (SDC1) expressions are upregulated, by 45- and 24-fold respectively, in…”
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Sulforaphane Inhibits Growth of Human Breast Cancer Cells and Augments the Therapeutic Index of the Chemotherapeutic Drug, Gemcitabine by Hussain, Arif, Mohsin, Javeria, Prabhu, Sathyen Alwin, Begum, Salema, Nusri, Qurrat El-Ain, Harish, Geetganga, Javed, Elham, Khan, Munawwar Ali, Sharma, Chhavi

“…Phytochemicals are among the natural chemopreventive agents with most potential for delaying, blocking or reversing the initiation and promotional events of…”
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