Effect of arsenic and chromium on the serum amino-transferases activity in Indian major carp, Labeo rohita

Arsenic and hexavalent chromium toxicity results from their ability to interact with sulfahydryl groups of proteins and enzymes, and to substitute phosphorus in a variety of biochemical reactions. Alanine aminotransferase (ALT; E.C: 2.6.1.2) and Aspartate amino transferase (AST; EC 2.6.1.1) play a c...

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Bibliographic Details
Published in:	International journal of environmental research and public health Vol. 4; no. 3; pp. 224 - 227
Main Authors:	Vutukuru, Sesha Srinivas, Prabhath, N Arun, Raghavender, M, Yerramilli, Anjaneyulu
Format:	Journal Article
Language:	English
Published:	Switzerland Molecular Diversity Preservation International (MDPI) 01-09-2007
Subjects:	Alanine Transaminase - blood Animals Arsenic - toxicity Aspartate Aminotransferases - blood Biomarkers - blood Carps - blood Chromium - toxicity Lethal Dose 50 Water Pollutants, Chemical - toxicity
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Summary:	Arsenic and hexavalent chromium toxicity results from their ability to interact with sulfahydryl groups of proteins and enzymes, and to substitute phosphorus in a variety of biochemical reactions. Alanine aminotransferase (ALT; E.C: 2.6.1.2) and Aspartate amino transferase (AST; EC 2.6.1.1) play a crucial role in transamination reactions and can be used as potential biomarkers to indicate hepatotoxicity and cellular damage. While histopathological studies in liver tissue require more time and expertise, simple and reliable biochemical analysis of ALT and AST can be used for a rapid assessment of tissue and cellular damage within 96 h. The main objective of this study was to determine the acute effects of arsenic and hexavalent chromium on the activity of ALT and AST in the Indian major carp, Labeo rohita for 24 h and 96 h. Significant increase in the activity of ALT (P < 0.01) from controls in arsenic exposed fish indicates serious hepatic damage and distress condition to the fish. However, no such significant changes were observed in chromium-exposed fish suggesting that arsenic is more toxic to the fish. These findings indicate that ALT and AST are candidate biomarkers for arsenic-induced hepatotoxicity in Labeo rohita.
ISSN:	1660-4601 1661-7827 1660-4601
DOI:	10.3390/ijerph2007030005