Search Results - "Praça, Catarina"
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Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases
Published in Journal of controlled release (10-08-2016)“…The blood–brain barrier (BBB) is a vital boundary between neural tissue and circulating blood. The BBB's unique and protective features control brain…”
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Journal Article -
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Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells
Published in Stem cell reports (08-10-2019)“…The derivation of human brain capillary endothelial cells is of utmost importance for drug discovery programs focusing on diseases of the central nervous…”
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Journal Article -
3
A nanoformulation for the preferential accumulation in adult neurogenic niches
Published in Journal of controlled release (28-08-2018)“…Stimulation of adult neurogenesis by targeting the endogenous neural stem cells (NSCs), located in hippocampus and subventricular zone (SVZ), with…”
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Journal Article -
4
Re-Use of Caco-2 Monolayers in Permeability Assays—Validation Regarding Cell Monolayer Integrity
Published in Pharmaceutics (26-09-2021)“…Caco-2 monolayers are a common in vitro model used to evaluate human intestinal absorption. The reference protocol requires 21 days post-seeding to establish a…”
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Journal Article -
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Brain-Like Endothelial Cells Derived from Stem Cells to Study BBB Development and Targeting
Published 01-01-2016“…The blood-brain barrier (BBB) is a dynamic and complex structure that physically separates the bloodstream from the brain being responsible for its homeostasis…”
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Dissertation -
6
The Effect of Methamphetamine on the Crosstalk Between Endothelial Cells and Astrocytes
Published 01-01-2011“…A metanfetamina (MET) é uma droga de abuso psicoestimulante que causa alterações severas no sistema nervoso central. De forma a explicar a neurotoxicidade…”
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Dissertation