Complex cutaneous leishmaniasis with bone involvement

We report an immunocompromised patient with a complex cutaneous leishmaniasis (CL) who suffered from singular bone involvement of the little left toe due to Leishmania (L.) infantum infection. The diagnosis was confirmed by positive polymerase chain reaction (PCR) testing in skin and bone tissue. Th...

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Bibliographic Details
Published in:	Dermatologie (Heidelberg, Germany) Vol. 75; no. 8; p. 647
Main Authors:	Hübner, G A, Prüßmann, W, Jossifov, N, Mischnik, A, Terheyden, P
Format:	Journal Article
Language:	German
Published:	Germany 01-08-2024
Subjects:	Antiprotozoal Agents - therapeutic use Humans Immunocompromised Host Leishmania infantum - isolation & purification Leishmaniasis, Cutaneous - diagnosis Leishmaniasis, Cutaneous - drug therapy Leishmaniasis, Cutaneous - parasitology Leishmaniasis, Cutaneous - pathology Male Phosphorylcholine - analogs & derivatives Phosphorylcholine - therapeutic use Polymerase chain reaction Immunosuppression Leishmania infantum Skin manifestations Pathogen diagnostics
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Summary:	We report an immunocompromised patient with a complex cutaneous leishmaniasis (CL) who suffered from singular bone involvement of the little left toe due to Leishmania (L.) infantum infection. The diagnosis was confirmed by positive polymerase chain reaction (PCR) testing in skin and bone tissue. The patient was successfully treated with miltefosine. In immunocompromised patients with CL, extracutaneous manifestations should always be ruled out. This is the first case report describing osseous involvement in CL due to Leishmania infantum.
ISSN:	2731-7013
DOI:	10.1007/s00105-024-05355-2