Search Results - "Pozzi, J."

Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications by Roma, Marcelo G, Toledo, Flavia D, Boaglio, Andrea C, Basiglio, Cecilia L, Crocenzi, Fernando A, Sánchez Pozzi, Enrique J

“…UDCA (ursodeoxycholic acid) is the therapeutic agent most widely used for the treatment of cholestatic hepatopathies. Its use has expanded to other kinds of…”
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Oxidative Stress and Localization Status of Hepatocellular Transporters: Impact on Bile Secretion and Role of Signaling Pathways by Basiglio, Cecilia L, Crocenzi, Fernando A, Sánchez Pozzi, Enrique J, Roma, Marcelo G

“…Most hepatopathies are primarily or secondarily cholestatic in nature. Oxidative stress (OS) is a frequent trait among them, and impairs the machinery to…”
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First laboratory measurements of seismo-magnetic conversions in fluid-filled Fontainebleau sand by Bordes, C., Jouniaux, L., Dietrich, M., Pozzi, J.-P., Garambois, S.

“…Seismic wave propagation in fluid‐filled porous materials induces electromagnetic effects due to small relative pore‐fluid motions. In order to detect the…”
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NADPH oxidase-generated reactive oxygen species are involved in estradiol 17ß-d-glucuronide-induced cholestasis by Salas, Gimena, Litta, Alen A., Medeot, Anabela C., Schuck, Virginia S., Andermatten, Romina B., Miszczuk, Gisel S., Ciriaci, Nadia, Razori, Ma Valeria, Barosso, Ismael R., Sánchez Pozzi, Enrique J., Roma, Marcelo G., Basiglio, Cecilia L., Crocenzi, Fernando A.

“…The endogenous metabolite of estradiol, estradiol 17β-D-glucuronide (E17G), is considered the main responsible of the intrahepatic cholestasis of pregnancy…”
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Anticholestatic mechanisms of ursodeoxycholic acid in lipopolysaccharide-induced cholestasis by Razori, María Valeria, Maidagan, Paula M., Ciriaci, Nadia, Andermatten, Romina B., Barosso, Ismael R., Martín, Pamela L., Basiglio, Cecilia L., Sánchez Pozzi, Enrique J., Ruiz, María Laura, Roma, Marcelo G.

“…[Display omitted] Lipopolysaccharide (LPS) from Gram (-) bacteria induces inflammatory cholestasis by impairing the expression/localization of transporters…”
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Mechanisms of canalicular transporter endocytosis in the cholestatic rat liver by Miszczuk, Gisel S., Barosso, Ismael R., Larocca, María Cecilia, Marrone, Julieta, Marinelli, Raúl A., Boaglio, Andrea C., Sánchez Pozzi, Enrique J., Roma, Marcelo G., Crocenzi, Fernando A.

“…Impaired canalicular secretion due to increased endocytosis and intracellular retention of canalicular transporters such as BSEP and MRP2 is a main, common…”
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Spironolactone ameliorates lipopolysaccharide-induced cholestasis in rats by improving Mrp2 function: Role of transcriptional and post-transcriptional mechanisms by Razori, María Valeria, Martín, Pamela L., Maidagan, Paula M., Barosso, Ismael R., Ciriaci, Nadia, Andermatten, Romina B., Sánchez Pozzi, Enrique J., Basiglio, Cecilia L., Ruiz, María Laura, Roma, Marcelo G.

“…Lipopolysaccharide (LPS) induces inflammatory cholestasis by impairing expression, localization, and function of carriers involved in bile formation, e.g. bile…”
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G‐protein‐coupled receptor 30/adenylyl cyclase/protein kinase A pathway is involved in estradiol 17ß‐d‐glucuronide‐induced cholestasis by Zucchetti, Andrés E., Barosso, Ismael R., Boaglio, Andrea C., Basiglio, Cecilia L., Miszczuk, Gisel, Larocca, M. Cecilia, Ruiz, M. Laura, Davio, Carlos A., Roma, Marcelo G., Crocenzi, Fernando A., Pozzi, Enrique J. Sánchez

“…Estradiol‐17ß‐d‐glucuronide (E17G) activates different signaling pathways (e.g., Ca2+‐dependent protein kinase C, phosphoinositide 3‐kinase/protein kinase B,…”
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The Ca2+-calmodulin-Ca2+/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes by Toledo, Flavia D., Pérez, Leonardo M., Basiglio, Cecilia L., Ochoa, Justina E., Sanchez Pozzi, Enrique J., Roma, Marcelo G.

“…Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation…”
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Phosphoinositide 3‐kinase/protein kinase B signaling pathway is involved in estradiol 17β‐d‐glucuronide–induced cholestasis: Complementarity with classical protein kinase c by Boaglio, Andrea C., Zucchetti, Andrés E., Sánchez Pozzi, Enrique J., Pellegrino, José M., Ochoa, Justina Elena, Mottino, Aldo D., Vore, Mary, Crocenzi, Fernando A., Roma, Marcelo G.

“…Estradiol 17β‐D‐glucuronide (E217G) is an endogenous, cholestatic metabolite that induces endocytic internalization of the canalicular transporters relevant to…”
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EGFR participates downstream of ERα in estradiol-17β-d-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets by Barosso, Ismael R., Zucchetti, Andrés E., Miszczuk, Gisel S., Boaglio, Andrea C., Taborda, Diego R., Roma, Marcelo G., Crocenzi, Fernando A., Sánchez Pozzi, Enrique J.

“…Estradiol-17β- d -glucuronide (E17G) induces acute endocytic internalization of canalicular transporters, including multidrug resistance-associated protein 2…”
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Mitogen-activated protein kinases are involved in hepatocanalicular dysfunction and cholestasis induced by oxidative stress by Toledo, Flavia D., Basiglio, Cecilia L., Barosso, Ismael R., Boaglio, Andrea C., Zucchetti, Andrés E., Sánchez Pozzi, Enrique J., Roma, Marcelo G.

“…In previous studies, we showed that the pro-oxidant model agent tert -butyl hydroperoxide ( t BuOOH) induces alterations in hepatocanalicular secretory…”
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Activation of insulin-like growth factor 1 receptor participates downstream of GPR30 in estradiol-17β-d-glucuronide-induced cholestasis in rats by Barosso, Ismael R., Miszczuk, Gisel S., Ciriaci, Nadia, Andermatten, Romina B., Maidagan, Paula M., Razori, Valeria, Taborda, Diego R., Roma, Marcelo G., Crocenzi, Fernando A., Sánchez Pozzi, Enrique J.

“…Estradiol-17β- d -glucuronide (E17G), through the activation of different signaling proteins, induces acute endocytic internalization of canalicular…”
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Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis by Basiglio, Cecilia L., Sánchez Pozzi, Enrique J., Mottino, Aldo D., Roma, Marcelo G.

“…Silymarin (SIL) is a natural extract with hepatoprotective properties composed mainly of flavonolignans, with silibinin (SB) being its principal constituent…”
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Oxidative Stress Induces Internalization of the Bile Salt Export Pump, Bsep, and Bile Salt Secretory Failure in Isolated Rat Hepatocyte Couplets: A Role for Protein Kinase C and Prevention by Protein Kinase A by Pérez, Leonardo M., Milkiewicz, Piotr, Elias, Elwyn, Coleman, Roger, Sánchez Pozzi, Enrique J., Roma, Marcelo G.

“…We have shown that Ca2+-mediated protein kinase C (PKC) activation induces impairment of bile salt secretory function and F-actin redistribution in hepatocyte…”
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ERK1/2 and p38 MAPKs are complementarily involved in estradiol 17ß-D-glucuronide-induced cholestasis: crosstalk with cPKC and PI3K by Boaglio, Andrea C, Zucchetti, Andrés E, Toledo, Flavia D, Barosso, Ismael R, Sánchez Pozzi, Enrique J, Crocenzi, Fernando A, Roma, Marcelo G

“…The endogenous, cholestatic metabolite estradiol 17ß-D-glucuronide (E(2)17G) induces endocytic internalization of the canalicular transporters relevant to bile…”
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Hormonal Modulation of Hepatic cAMP Prevents Estradiol 17β-d-Glucuronide-Induced Cholestasis in Perfused Rat Liver by Zucchetti, Andrés E., Barosso, Ismael R., Boaglio, Andrea C., Luquita, Marcelo G., Roma, Marcelo G., Crocenzi, Fernando A., Sánchez Pozzi, Enrique J.

“…Background Estradiol-17β- d -glucuronide (E17G) induces cholestasis in vivo, endocytic internalization of the canalicular transporters multidrug…”
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Sandwich-cultured rat hepatocytes as an in vitro model to study canalicular transport alterations in cholestasis by Miszczuk, Gisel S., Barosso, Ismael R., Zucchetti, Andrés E., Boaglio, Andrea C., Pellegrino, José M., Sánchez Pozzi, Enrique J., Roma, Marcelo G., Crocenzi, Fernando A.

“…At present, it has not been systematically evaluated whether the functional alterations induced by cholestatic compounds in canalicular transporters involved…”
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Oxidative stress: a radical way to stop making bile by Roma, Marcelo G, Sanchez Pozzi, Enrique J

“…Oxidative stress is a common feature in most hepatopathies. In recent years, evidence has accumulated that reactive oxygen species (ROS) induce a number of…”
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Physiological concentrations of unconjugated bilirubin prevent oxidative stress-induced hepatocanalicular dysfunction and cholestasis by Basiglio, Cecilia L., Toledo, Flavia D., Boaglio, Andrea C., Arriaga, Sandra M., Ochoa, Justina E., Sánchez Pozzi, Enrique J., Mottino, Aldo D., Roma, Marcelo G.

“…Bilirubin is an endogenous antioxidant with cytoprotective properties, and several studies highlight its potential in the treatment of pro-oxidant diseases. We…”
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