Search Results - "Pozo, Oscar"

Determination of steroid profile in hair by liquid chromatography tandem mass spectrometry by Gomez-Gomez, Alex, Pozo, Oscar J.

“…•A LC-MS/MS for the quantification of steroid profile in hair is validated.•Sample treatment, extraction, preconcentration and MS parameters are…”
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Current LC–MS methods and procedures applied to the identification of new steroid metabolites by Marcos, Josep, Pozo, Oscar J.

“…[Display omitted] •The application of LC–MS strategies for the discovery of steroid metabolites is reviewed.•Mobile phase selection on LC is important for a…”
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Investigation of endogenous corticosteroids profiles in human urine based on liquid chromatography tandem mass spectrometry by Marcos, Josep, Renau, Nuria, Casals, Gregori, Segura, Jordi, Ventura, Rosa, Pozo, Oscar J.

“…•A method for the quantification of 67 endogenous corticosteroids is presented.•The validation data proved that the method fits for its intended…”
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Maternal separation induces neuroinflammation and long-lasting emotional alterations in mice by Gracia-Rubio, Irene, Moscoso-Castro, Maria, Pozo, Oscar J., Marcos, Josep, Nadal, Roser, Valverde, Olga

“…Early life experiences play a key role in brain function and behaviour. Adverse events during childhood are therefore a risk factor for psychiatric disease…”
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Derivatization of steroids in biological samples for GC-MS and LC-MS analyses by Marcos, Josep, Pozo, Oscar J

“…The determination of steroids in biological samples is essential in different areas of knowledge. MS combined with either GC or LC is considered the best…”
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Use of LC-MS/MS for the Open Detection of Steroid Metabolites Conjugated with Glucuronic Acid by Fabregat, Andreu, Pozo, Oscar J, Marcos, Josep, Segura, Jordi, Ventura, Rosa

“…In humans, conjugation with glucuronic acid is the most important phase II metabolic reaction of steroidal compounds. Glucuronoconjugated metabolites have been…”
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Longitudinal Associations between Prenatal Exposure to Phthalates and Steroid Hormones in Maternal Hair Samples from the SEPAGES Cohort by Mustieles, Vicente, Lascouts, Aurélien, Pozo, Oscar J., Haro, Noemí, Lyon-Caen, Sarah, Jedynak, Paulina, Bayat, Sam, Thomsen, Cathrine, Sakhi, Amrit K., Sabaredzovic, Azemira, Slama, Rémy, Ouellet-Morin, Isabelle, Philippat, Claire

“…We assessed phthalate-hormone associations in 382 pregnant women of the new-generation SEPAGES cohort (2014–2017, France) using improved exposure and outcome…”
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Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients by Marín-Corral, Judith, Rodríguez-Morató, Jose, Gomez-Gomez, Alex, Pascual-Guardia, Sergi, Muñoz-Bermúdez, Rosana, Salazar-Degracia, Anna, Pérez-Terán, Purificación, Restrepo, Marcos I, Khymenets, Olha, Haro, Noemí, Masclans, Joan Ramon, Pozo, Oscar J

“…The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their…”
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Metabolomic approaches for orange origin discrimination by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry by Díaz, Ramon, Pozo, Oscar J., Sancho, Juan V., Hernández, Félix

“…•We performed an untargeted metabolic fingerprint for oranges origin differentiation.•UHPLC-(Q)TOF MS data have been processed using XCMS and multivariate…”
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Targeting tryptophan and tyrosine metabolism by liquid chromatography tandem mass spectrometry by Marcos, Josep, Renau, Nuria, Valverde, Olga, Aznar-Laín, Gemma, Gracia-Rubio, Irene, Gonzalez-Sepulveda, Marta, Pérez-Jurado, Luis Alberto, Ventura, Rosa, Segura, Jordi, Pozo, Oscar J.

“…•An LC–MS/MS method for the study of tryptophan and tyrosine metabolism is presented.•Concurrent quantification of 4 competitive large neutral amino acids is…”
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Determination of the steroid profile in alternative matrices by liquid chromatography tandem mass spectrometry by Gomez-Gomez, Alex, Miranda, Jezid, Feixas, Georgina, Arranz Betegon, Angela, Crispi, Fatima, Gratacós, Eduard, Pozo, Oscar J.

“…[Display omitted] •A LC–MS/MS method for steroids quantification in alternative matrices is validated.•The steroids endogenous range in saliva, breast milk and…”
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Comprehensive analysis of the tryptophan metabolome in urine of patients with acute intermittent porphyria by Gomez-Gomez, Alex, Marcos, Josep, Aguilera, Paula, To-Figueras, Jordi, Pozo, Oscar J

“…•Targeted metabolomics is used for the study of Tryptophan metabolism in AIP patients.•AIP patients show increased urinary excretion of kynurenine.•AIP…”
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Determination of well-being-related markers in nails by liquid chromatography tandem mass spectrometry by Gomez-Gomez, Alex, Martin, Blanca Montero-San, Haro, Noemí, Pozo, Oscar J.

“…Well-being is a multifactorial positive state that is highly influenced by some endogenous molecules that control happiness and euphoric feelings. These…”
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Untargeted detection of the carbonyl metabolome by chemical derivatization and liquid chromatography-tandem mass spectrometry in precursor ion scan mode: Elucidation of COVID-19 severity biomarkers by Gomez-Gomez, Alex, Rodríguez-Morató, Jose, Haro, Noemí, Marín-Corral, Judith, Masclans, Joan Ramon, Pozo, Oscar J.

“…Metabolomics (both targeted and untargeted) has become the gold standard in biomarker discovery. Whereas targeted approaches only provide information for the…”
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Synthesis of 3α,6β‐Dihydroxyandrostan‐17‐one 3‐Glucuronides for the Detection of Testosterone Misuse by Thomas, Komba, Khymenets, Olha, Pozo, Oscar J., McLeod, Malcolm D.

“…The convenient synthesis of two 3‐glucuronide conjugates of 6β‐hydroxyandrosterone (6OH‐And‐3G 2) and 6β‐hydroxyetiocholanolone (6OH‐Etio‐3G 3) is reported…”
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Determination of up to twenty carboxylic acid containing compounds in clinically relevant matrices by o-benzylhydroxylamine derivatization and liquid chromatography-tandem mass spectrometry by Gomez-Gomez, Alex, Olesti, Eulàlia, Montero-San-Martin, Blanca, Soldevila, Angie, Deschamps, Tessa, Pizarro, Nieves, de la Torre, Rafael, Pozo, Oscar J.

“…Carboxylic acid containing compounds (R-COOH) are involved in a large number of biological processes and they are relevant for several pathological processes…”
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Evaluation of Metabolic Changes in Acute Intermittent Porphyria Patients by Targeted Metabolomics by Gomez-Gomez, Alex, Aguilera, Paula, Langohr, Klaus, Casals, Gregori, Pavon, Cristina, Marcos, Josep, To-Figueras, Jordi, Pozo, Oscar J

“…Acute intermittent porphyria (AIP) is an inherited rare hepatic disorder due to mutations within the hydroxymethylbilane gene. AIP patients with active disease…”
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Towards the non-invasive determination of estradiol levels: Development and validation of an LC-MS/MS assay for quantification of salivary estradiol at sub-pg/mL level by Fabregat-Safont, David, Alechaga, Élida, Haro, Noemí, Gomez-Gomez, Àlex, Velasco, Eric R., Nabás, Jaime F., Andero, Raül, Pozo, Oscar J.

“…Estradiol (E2) is a female sex hormone involved in several biological processes. Although E2 levels are commonly measured in blood samples, the use of…”
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Quantifying endogenous androgens, estrogens, pregnenolone and progesterone metabolites in human urine by gas chromatography tandem mass spectrometry by Robles, Juan, Marcos, Josep, Renau, Nuria, Garrostas, Lorena, Segura, Jordi, Ventura, Rosa, Barceló, Bernardí, Barceló, Antonia, Pozo, Oscar J.

“…A method for the quantitation of 22 urinary steroids (androgens, estrogens and the main pregnenolone and progesterone metabolites) by means of gas…”
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Dysregulation of homocysteine homeostasis in acute intermittent porphyria patients receiving heme arginate or givosiran by To‐Figueras, Jordi, Wijngaard, Robin, García‐Villoria, Judit, Aarsand, Aasne K., Aguilera, Paula, Deulofeu, Ramon, Brunet, Mercè, Gómez‐Gómez, Àlex, Pozo, Oscar J., Sandberg, Sverre

“…Acute intermittent porphyria (AIP) is a rare metabolic disease caused by mutations within the hydroxymethylbilane synthase gene. Previous studies have reported…”
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