Search Results - "Pozniak, Marta"

The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells by Poźniak, Marta, Porębska, Natalia, Krzyścik, Mateusz Adam, Sokołowska-Wędzina, Aleksandra, Jastrzębski, Kamil, Sochacka, Martyna, Szymczyk, Jakub, Zakrzewska, Małgorzata, Otlewski, Jacek, Opaliński, Łukasz

“…Antibody drug conjugates (ADCs) represent one of the most promising approaches in the current immuno-oncology research. The precise delivery of cytotoxic drugs…”
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The diverse dependence of galectin-1 and -8 on multivalency for the modulation of FGFR1 endocytosis by Żukowska, Dominika, Chorążewska, Aleksandra, Ciura, Krzysztof, Gędaj, Aleksandra, Kalka, Marta, Poźniak, Marta, Porębska, Natalia, Opaliński, Łukasz

“…Fibroblast growth factor receptor 1 (FGFR1) is a N-glycosylated cell surface receptor tyrosine kinase, which upon recognition of specific extracellular…”
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Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors by Poźniak, Marta, PorÄbska, Natalia, JastrzÄbski, Kamil, KrzyÅcik, Mateusz Adam, KuciÅska, Marika, Zarzycka, Weronika, Barbach, Agnieszka, Zakrzewska, MaÅgorzata, Otlewski, Jacek, MiÄczyÅska, Marta, OpaliÅski, Åukasz

“…Background Overexpression of FGFR1 is observed in numerous tumors and therefore this receptor constitutes an attractive molecular target for selective cancer…”
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Correction: Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling by Gedaj, Aleksandra, Zukowska, Dominika, Porebska, Natalia, Pozniak, Marta, Krzyscik, Mateusz, Czyrek, Aleksandra, Krowarsch, Daniel, Zakrzewska, Malgorzata, Otlewski, Jacek, Opalinski, Lukasz

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Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling by Gedaj, Aleksandra, Zukowska, Dominika, Porebska, Natalia, Pozniak, Marta, Krzyscik, Mateusz, Czyrek, Aleksandra, Krowarsch, Daniel, Zakrzewska, Malgorzata, Otlewski, Jacek, Opalinski, Lukasz

“…Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute complex signaling hubs that are crucial for the development and homeostasis of the…”
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FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization by Pozniak, Marta, Sokolowska‐Wedzina, Aleksandra, Jastrzebski, Kamil, Szymczyk, Jakub, Porebska, Natalia, Krzyscik, Mateusz Adam, Zakrzewska, Malgorzata, Miaczynska, Marta, Otlewski, Jacek, Opalinski, Lukasz

“…Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility,…”
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Intrinsically Fluorescent Oligomeric Cytotoxic Conjugates Toxic for FGFR1-Overproducing Cancers by Porębska, Natalia, Knapik, Agata, Poźniak, Marta, Krzyścik, Mateusz Adam, Zakrzewska, Małgorzata, Otlewski, Jacek, Opaliński, Łukasz

“…Fibroblast growth factor receptor 1 (FGFR1) is an integral membrane protein that transmits prolife signals through the plasma membrane. Overexpression of FGFR1…”
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Galectins as modulators of receptor tyrosine kinases signaling in health and disease by Porębska, Natalia, Poźniak, Marta, Matynia, Aleksandra, Żukowska, Dominika, Zakrzewska, Małgorzata, Otlewski, Jacek, Opaliński, Łukasz

“…[Display omitted] •Receptor tyrosine kinases (RTKs) regulate pivotal cellular processes and are dysregulated in cancer.•RTKs are extensively glycosylated and…”
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The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine Kinases by Poźniak, Marta, Żukowska, Dominika, Gędaj, Aleksandra, Krzyścik, Mateusz Adam, Porębska, Natalia, Zakrzewska, Małgorzata, Otlewski, Jacek, Opaliński, Łukasz

“…Precise anticancer therapies employing cytotoxic conjugates constitute a side-effect-limited, highly attractive alternative to commonly used cancer treatment…”
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FGF1 Fusions with the Fc Fragment of IgG1 for the Assembly of GFPpolygons-Mediated Multivalent Complexes Recognizing FGFRs by Poźniak, Marta, Zarzycka, Weronika, Porębska, Natalia, Knapik, Agata, Marczakiewicz-Perera, Paulina, Zakrzewska, Malgorzata, Otlewski, Jacek, Opaliński, Łukasz

“…FGFRs are cell surface receptors that, when activated by specific FGFs ligands, transmit signals through the plasma membrane, regulating key cellular processes…”
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Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling by Zukowska, Dominika, Gedaj, Aleksandra, Porebska, Natalia, Pozniak, Marta, Krzyscik, Mateusz, Czyrek, Aleksandra, Krowarsch, Daniel, Zakrzewska, Malgorzata, Otlewski, Jacek, Opalinski, Lukasz

“…FGF/FGFR signaling is critical for the development and homeostasis of the human body and imbalanced FGF/FGFR contributes to the progression of severe diseases,…”
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Short report galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling by Gedaj, Aleksandra, Zukowska, Dominika, Porebska, Natalia, Pozniak, Marta, Krzyscik, Mateusz, Czyrek, Aleksandra, Krowarsch, Daniel, Zakrzewska, Malgorzata, Otlewski, Jacek, Opalinski, Lukasz

“…Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute complex signaling hubs that are crucial for the development and homeostasis of the…”
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Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1 by Porebska, Natalia, Pozniak, Marta, Krzyscik, Mateusz Adam, Knapik, Agata, Czyrek, Aleksandra, Kucinska, Marika, Jastrzebski, Kamil, Zakrzewska, Malgorzata, Otlewski, Jacek, Opalinski, Lukasz

“…Fibroblast growth factor receptors (FGFRs) are integral membrane proteins involved in various biological processes including proliferation, migration and…”
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Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation by Krzyscik, Mateusz Adam, Sokolowska-Wedzina, Aleksandra, Jendryczko, Karolina, Pozniak, Marta, Nawrocka, Daria, Porebska, Natalia, Zakrzewska, Malgorzata, Otlewski, Jacek, Szlachcic, Anna, Opalinski, Lukasz

“…Cancer is currently the second most common cause of death worldwide. The hallmark of cancer cells is the presence of specific marker proteins such as growth…”
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