Search Results - "Poznansky, Mark"

mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant by Garcia-Beltran, Wilfredo F., St. Denis, Kerri J., Hoelzemer, Angelique, Lam, Evan C., Nitido, Adam D., Sheehan, Maegan L., Berrios, Cristhian, Ofoman, Onosereme, Chang, Christina C., Hauser, Blake M., Feldman, Jared, Roederer, Alex L., Gregory, David J., Poznansky, Mark C., Schmidt, Aaron G., Iafrate, A. John, Naranbhai, Vivek, Balazs, Alejandro B.

“…Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, the target of…”
Get full text

CXCR4 antagonist AMD3100 (plerixafor): From an impurity to a therapeutic agent by Wang, Jingzhe, Tannous, Bakhos A., Poznansky, Mark C., Chen, Huabiao

“…[Display omitted] AMD3100 (plerixafor), a CXCR4 antagonist, has opened a variety of avenues for potential therapeutic approaches in different refractory…”
Get full text

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity by Garcia-Beltran, Wilfredo F., Lam, Evan C., St. Denis, Kerri, Nitido, Adam D., Garcia, Zeidy H., Hauser, Blake M., Feldman, Jared, Pavlovic, Maia N., Gregory, David J., Poznansky, Mark C., Sigal, Alex, Schmidt, Aaron G., Iafrate, A. John, Naranbhai, Vivek, Balazs, Alejandro B.

“…Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants…”
Get full text

Dual blockade of CXCL12‐CXCR4 and PD‐1–PD‐L1 pathways prolongs survival of ovarian tumor–bearing mice by prevention of immunosuppression in the tumor microenvironment by Zeng, Yang, Li, Binghao, Liang, Yingying, Reeves, Patrick M., Qu, Xiying, Ran, Chongzhao, Liu, Qiuyan, Callahan, Michael V., Sluder, Ann E., Gelfand, Jeffrey A., Chen, Huabiao, Poznansky, Mark C.

“…ABSTRACTBlockade of immune‐checkpoint programmed cell death protein 1 (PD‐1) or programmed cell death ligand 1 can enhance effector T‐cell responses. However,…”
Get full text

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy by Huang, Yuhui, Yuan, Jianping, Righi, Elda, Kamoun, Walid S., Ancukiewicz, Marek, Nezivar, Jean, Santosuosso, Michael, Martin, John D., Martin, Margaret R., Vianello, Fabrizio, Leblanc, Pierre, Munn, Lance L., Huang, Peigen, Duda, Dan G., Fukumura, Dai, Jain, Rakesh K., Poznansky, Mark C.

“…The recent approval of a prostate cancer vaccine has renewed hope for anticancer immunotherapies. However, the immunosuppressive tumor microenvironment may…”
Get full text

A HABA dye-based colorimetric assay to detect unoccupied biotin binding sites in an avidin-containing fusion protein by Mukherjee, Sonia, Leblanc, Pierre, Poznansky, Mark C, Sluder, Ann E

“…Avidin-biotin binding, the most robust non-covalent protein-ligand interaction occurring in nature, has wide-ranging applications in biotechnology. A frequent…”
Get full text

Rethinking the role of hydroxychloroquine in the treatment of COVID‐19 by Meyerowitz, Eric A., Vannier, Augustin G. L., Friesen, Morgan G. N., Schoenfeld, Sara, Gelfand, Jeffrey A., Callahan, Michael V., Kim, Arthur Y., Reeves, Patrick M., Poznansky, Mark C.

“…There are currently no proven or approved treatments for coronavirus disease 2019 (COVID‐19). Early anecdotal reports and limited in vitro data led to the…”
Get full text

Mathematical Modeling to Simulate the Effect of Adding Radiation Therapy to Immunotherapy and Application to Hepatocellular Carcinoma by Sung, Wonmo, Hong, Theodore S., Poznansky, Mark C., Paganetti, Harald, Grassberger, Clemens

“…To develop a comprehensive framework to simulate the response to immune checkpoint inhibitors (ICIs) in combination with radiation therapy (RT) and to apply…”
Get full text

Immunomodulatory drugs: a promising clinical ally for cancer immunotherapy by Colley, Abigail, Brauns, Timothy, Sluder, Ann E., Poznansky, Mark C., Gemechu, Yohannes

“…Immunomodulatory drugs (IMiDs) are well-established anticancer agents for the treatment of haematological malignancies, in particular multiple myeloma…”
Get full text

Precise reconstruction of the TME using bulk RNA-seq and a machine learning algorithm trained on artificial transcriptomes by Zaitsev, Aleksandr, Chelushkin, Maksim, Dyikanov, Daniiar, Cheremushkin, Ilya, Shpak, Boris, Nomie, Krystle, Zyrin, Vladimir, Nuzhdina, Ekaterina, Lozinsky, Yaroslav, Zotova, Anastasia, Degryse, Sandrine, Kotlov, Nikita, Baisangurov, Artur, Shatsky, Vladimir, Afenteva, Daria, Kuznetsov, Alexander, Paul, Susan Raju, Davies, Diane L., Reeves, Patrick M., Lanuti, Michael, Goldberg, Michael F., Tazearslan, Cagdas, Chasse, Madison, Wang, Iris, Abdou, Mary, Aslanian, Sharon M., Andrewes, Samuel, Hsieh, James J., Ramachandran, Akshaya, Lyu, Yang, Galkin, Ilia, Svekolkin, Viktor, Cerchietti, Leandro, Poznansky, Mark C., Ataullakhanov, Ravshan, Fowler, Nathan, Bagaev, Alexander

“…Cellular deconvolution algorithms virtually reconstruct tissue composition by analyzing the gene expression of complex tissues. We present the decision tree…”
Get full text

Standardized guinea pig model for Q fever vaccine reactogenicity by Baeten, Laurie A, Podell, Brendan K, Sluder, Ann E, Garritsen, Anja, Bowen, Richard A, Poznansky, Mark C

“…Historically, vaccination with Coxiella burnetii whole cell vaccines has induced hypersensitivity reactions in humans and animals that have had prior exposure…”
Get full text

Targeting metabolic pathways to counter cancer immunotherapy resistance by Agarwala, Yuki, Brauns, Timothy A., Sluder, Ann E., Poznansky, Mark C., Gemechu, Yohannes

“…Metabolic modifiers can be efficacious in improving immune cell infiltration for various immunotherapeutic approaches, including immune checkpoint inhibitors,…”
Get full text

Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma by Li, Binghao, Wang, Zhan, Wu, Hao, Xue, Mingfeng, Lin, Peng, Wang, Shengdong, Lin, Nong, Huang, Xin, Pan, Weibo, Liu, Meng, Yan, Xiaobo, Qu, Hao, Sun, Lingling, Li, Hengyuan, Wu, Yan, Teng, Wangsiyuan, Wang, Zenan, Zhou, Xingzhi, Chen, Huabiao, Poznansky, Mark C, Ye, Zhaoming

“…The mechanism by which osteosarcomas metastasize is elusive, and challenges remain regarding its treatment with modalities including immunotherapy. CXCL12 is…”
Get full text

Comparative Immunogenicity and Effectiveness of mRNA-1273, BNT162b2, and Ad26.COV2.S COVID-19 Vaccines by Naranbhai, Vivek, Garcia-Beltran, Wilfredo F, Chang, Christina C, Berrios Mairena, Cristhian, Thierauf, Julia C, Kirkpatrick, Grace, Onozato, Maristela L, Cheng, Ju, St Denis, Kerri J, Lam, Evan C, Kaseke, Clarety, Tano-Menka, Rhoda, Yang, Diane, Pavlovic, Maia, Yang, Wendy, Kui, Alexander, Miller, Tyler E, Astudillo, Michael G, Cahill, Jennifer E, Dighe, Anand S, Gregory, David J, Poznansky, Mark C, Gaiha, Gaurav D, Balazs, Alejandro B, Iafrate, A John

“…Abstract Background Understanding immunogenicity and effectiveness of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines is critical to…”
Get full text

Alginate‐microencapsulation of human stem cell–derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression by Alagpulinsa, David A., Cao, Jenny J. L., Driscoll, Riley K., Sîrbulescu, Ruxandra F., Penson, Madeline F. E., Sremac, Marinko, Engquist, Elise N., Brauns, Timothy A., Markmann, James F., Melton, Douglas A., Poznansky, Mark C.

“…Pancreatic β‐cell replacement by islet transplantation for the treatment of type 1 diabetes (T1D) is currently limited by donor tissue scarcity and the…”
Get full text

Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions by Sîrbulescu, Ruxandra F., Boehm, Chloe K., Soon, Erin, Wilks, Moses Q., Ilieş, Iulian, Yuan, Hushan, Maxner, Ben, Chronos, Nicolas, Kaittanis, Charalambos, Normandin, Marc D., El Fakhri, Georges, Orgill, Dennis P., Sluder, Ann E., Poznansky, Mark C.

“…Chronic wounds affect 12–15% of patients with diabetes and are associated with a drastic decrease in their quality of life. Here, we demonstrate that purified…”
Get full text

High Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chelsea, Massachusetts by Naranbhai, Vivek, Chang, Christina C, Beltran, Wilfredo F Garcia, Miller, Tyler E, Astudillo, Michael G, Villalba, Julian A, Yang, Diane, Gelfand, Jeffrey, Bernstein, Bradley E, Feldman, Jared, Hauser, Blake M, Caradonna, Timothy M, Alter, Galit, Murali, Mandakolathur R, Jasrasaria, Rashmi, Quinlan, Joan, Xerras, Dean C, Betancourt, Joseph R, Louis, David N, Schmidt, Aaron G, Lennerz, Jochen, Poznansky, Mark C, Iafrate, A John

“…Abstract SARS-CoV-2 antibody testing allows quantitative determination of disease prevalence, which is especially important in high-risk communities. We…”
Get full text

B cell treatment promotes a neuroprotective microenvironment after traumatic brain injury through reciprocal immunomodulation with infiltrating peripheral myeloid cells by Dwyer, Liam J, Maheshwari, Saumya, Levy, Emily, Poznansky, Mark C, Whalen, Michael J, Sîrbulescu, Ruxandra F

“…Traumatic brain injury (TBI) remains a major cause of death and severe disability worldwide. We found previously that treatment with exogenous naïve B cells…”
Get full text

Harnessing CXCL12 signaling to protect and preserve functional β-cell mass and for cell replacement in type 1 diabetes by Alagpulinsa, David A., Cao, Jenny J.L., Sobell, Don, Poznansky, Mark C.

“…Type 1 diabetes (T1D) is a complex multifactorial disease characterized by autoimmune destruction of insulin-producing pancreatic β cells. Our understanding of…”
Get full text

CXCL12/CXCR4 Blockade Induces Multimodal Antitumor Effects That Prolong Survival in an Immunocompetent Mouse Model of Ovarian Cancer by RIGHI, Elda, KASHIWAGI, Satoshi, KOWALSKI, Magdalena, CRISTINA MINGARI, Maria, VIANELLO, Fabrizio, BIRRER, Michael, ORSULIC, Sandra, DRANOFF, Glenn, POZNANSKY, Mark C, JIANPING YUAN, SANTOSUOSSO, Michael, LEBLANC, Pierre, INGRAHAM, Rachel, FORBES, Benjamin, EDELBLUTE, Beth, COLLETTE, Brian, DEYIN XING

“…The chemokine CXCL12 and its receptor CXCR4 are expressed widely in human cancers, including ovarian cancer, in which they are associated with disease…”
Get full text