Search Results - "Pozdeev, Vitaly I."

Immune Conversion of Tumor Microenvironment by Oncolytic Viruses: The Protoparvovirus H-1PV Case Study by Marchini, Antonio, Daeffler, Laurent, Pozdeev, Vitaly I, Angelova, Assia, Rommelaere, Jean

“…Cancer cells utilize multiple mechanisms to evade and suppress anticancer immune responses creating a "cold" immunosuppressive tumor microenvironment…”
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Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis by Kiweler, Nicole, Delbrouck, Catherine, Pozdeev, Vitaly I., Neises, Laura, Soriano-Baguet, Leticia, Eiden, Kim, Xian, Feng, Benzarti, Mohaned, Haase, Lara, Koncina, Eric, Schmoetten, Maryse, Jaeger, Christian, Noman, Muhammad Zaeem, Vazquez, Alexei, Janji, Bassam, Dittmar, Gunnar, Brenner, Dirk, Letellier, Elisabeth, Meiser, Johannes

“…Metastasis is the most common cause of death in cancer patients. Canonical drugs target mainly the proliferative capacity of cancer cells, which leaves…”
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Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase by Qvartskhava, Natalia, Lang, Philipp A., Görg, Boris, Pozdeev, Vitaly I., Ortiz, Marina Pascual, Lang, Karl S., Bidmon, Hans J., Lang, Elisabeth, Leibrock, Christina B., Herebian, Diran, Bode, Johannes G., Lang, Florian, Häussinger, Dieter

“…Urea cycle defects and acute or chronic liver failure are linked to systemic hyperammonemia and often result in cerebral dysfunction and encephalopathy…”
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Formate promotes invasion and metastasis in reliance on lipid metabolism by Delbrouck, Catherine, Kiweler, Nicole, Chen, Oleg, Pozdeev, Vitaly I., Haase, Lara, Neises, Laura, Oudin, Anaïs, Fouquier d’Hérouël, Aymeric, Shen, Ruolin, Schlicker, Lisa, Halder, Rashi, Lesur, Antoine, Schuster, Anne, Lorenz, Nadja I., Jaeger, Christian, Feucherolles, Maureen, Frache, Gilles, Szpakowska, Martyna, Chevigne, Andy, Ronellenfitsch, Michael W., Moussay, Etienne, Piraud, Marie, Skupin, Alexander, Schulze, Almut, Niclou, Simone P., Letellier, Elisabeth, Meiser, Johannes

“…Metabolic rewiring is essential for cancer onset and progression. We previously showed that one-carbon metabolism-dependent formate production often exceeds…”
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Bile Acid-Induced Suicidal Erythrocyte Death by Lang, Elisabeth, Pozdeev, Vitaly I., Gatidis, Sergios, Qadri, Syed M., Häussinger, Dieter, Kubitz, Ralf, Herebian, Diran, Mayatepek, Ertan, Lang, Florian, Lang, Karl S., Lang, Philipp A.

“…Background/Aims: In nucleated cells, bile acids may activate cation channels subsequently leading to entry of Ca 2+ . In erythrocytes, increase of cytosolic Ca…”
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Storage of Erythrocytes Induces Suicidal Erythrocyte Death by Lang, Elisabeth, Pozdeev, Vitaly I., Xu, Haifeng C., Shinde, Prashant V., Behnke, Kristina, Hamdam, Junnat M., Lehnert, Erik, Scharf, Rüdiger E., Lang, Florian, Häussinger, Dieter, Lang, Karl S., Lang, Philipp A.

“…Background/Aims: Similar to apoptosis of nucleated cells, red blood cells (RBC) can undergo suicidal cell death - called eryptosis. It is characterized by cell…”
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Tumor Necrosis Factor-Mediated Survival of CD169 + Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection by Shinde, Prashant V, Xu, Haifeng C, Maney, Sathish Kumar, Kloetgen, Andreas, Namineni, Sukumar, Zhuang, Yuan, Honke, Nadine, Shaabani, Namir, Bellora, Nicolas, Doerrenberg, Mareike, Trilling, Mirko, Pozdeev, Vitaly I, van Rooijen, Nico, Scheu, Stefanie, Pfeffer, Klaus, Crocker, Paul R, Tanaka, Masato, Duggimpudi, Sujitha, Knolle, Percy, Heikenwalder, Mathias, Ruland, Jürgen, Mak, Tak W, Brenner, Dirk, Pandyra, Aleksandra A, Hoell, Jessica I, Borkhardt, Arndt, Häussinger, Dieter, Lang, Karl S, Lang, Philipp A

“…Innate immune activation is essential to mount an effective antiviral response and to prime adaptive immunity. Although a crucial role of CD169 cells during…”
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NK Cells Regulate CD8 + T Cell Mediated Autoimmunity by Lang, Philipp A, Crome, Sarah Q, Xu, Haifeng C, Lang, Karl S, Chapatte, Laurence, Deenick, Elissa K, Grusdat, Melanie, Pandyra, Aleksandra A, Pozdeev, Vitaly I, Wang, Ruifeng, Holderried, Tobias A W, Cantor, Harvey, Diefenbach, Andreas, Elford, Alisha R, McIlwain, David R, Recher, Mike, Häussinger, Dieter, Mak, Tak W, Ohashi, Pamela S

“…Elucidating key factors that regulate immune-mediated pathology is critical for developing improved strategies to treat autoimmune disease and cancer. NK cells…”
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TNFα induced up-regulation of Na+,K+,2Cl− cotransporter NKCC1 in hepatic ammonia clearance and cerebral ammonia toxicity by Pozdeev, Vitaly I., Lang, Elisabeth, Görg, Boris, Bidmon, Hans J., Shinde, Prashant V., Kircheis, Gerald, Herebian, Diran, Pfeffer, Klaus, Lang, Florian, Häussinger, Dieter, Lang, Karl S., Lang, Philipp A.

“…The devastating consequences of hepatic failure include hepatic encephalopathy, a severe, life threatening impairment of neuronal function. Hepatic…”
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Involvement of Toso in activation of monocytes, macrophages, and granulocytes by Lang, Karl S., Lang, Philipp A., Meryk, Andreas, Pandyra, Aleksandra A., Boucher, Louis-Martin, Pozdeev, Vitaly I., Tusche, Michael W., Göthert, Joachim R., Haight, Julian, Wakeham, Andrew, You-Ten, Annick J., MclIwain, David R., Merches, Katja, Khairnar, Vishal, Recher, Mike, Nolan, Garry P., Hitoshi, Yasumichi, Funkner, Pauline, Navarini, Alexander A., Verschoor, Admar, Shaabani, Namir, Honke, Nadine, Penn, Linda Z., Ohashi, Pamela S., Häussinger, Dieter, Lee, Kyeong-Hee, Mak, Tak W.

“…Rapid activation of immune responses is necessary for antibacterial defense, but excessive immune activation can result in life-threatening septic shock…”
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Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway by Qureshi-Baig, Komal, Kuhn, Diana, Viry, Elodie, Pozdeev, Vitaly I., Schmitz, Martine, Rodriguez, Fabien, Ullmann, Pit, Koncina, Eric, Nurmik, Martin, Frasquilho, Sonia, Nazarov, Petr V., Zuegel, Nikolaus, Boulmont, Marc, Karapetyan, Yervand, Antunes, Laurent, Val, Daniel, Mittelbronn, Michel, Janji, Bassam, Haan, Serge, Letellier, Elisabeth

“…In solid tumors, cancer stem cells (CSCs) or tumor-initiating cells (TICs) are often found in hypoxic niches. Nevertheless, the influence of hypoxia on TICs is…”
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RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production by Maney, Sathish Kumar, Xu, Haifeng C., Huang, Jun, Pandyra, Aleksandra A., Ehlting, Christian, Aguilar-Valenzuela, Renan, Pozdeev, Vitaly I., McIlwain, David R., Zimmermann, Albert, Bode, Johannes G., Hengel, Hartmut, Kirschning, Carsten J., Kim, Ira R., Hiscott, John, Brenner, Dirk, Häussinger, Dieter, Ohashi, Pamela S., Mak, Tak W., Lang, Karl S., Lang, Philipp A.

“…Background/Aims: Viral infections represent a global health problem with the need for new viral therapies and better understanding of the immune response…”
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Cholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection by Lang, Elisabeth, Pozdeev, Vitaly I., Shinde, Prashant V., Xu, Haifeng C., Sundaram, Balamurugan, Zhuang, Yuan, Poschmann, Gereon, Huang, Jun, Stühler, Kai, Pandyra, Aleksandra A., Keitel, Verena, Häussinger, Dieter, Lang, Karl S., Lang, Philipp A.

“…Immune responses are critical for defense against pathogens. However, prolonged viral infection can result in defective T cell immunity, leading to chronic…”
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T‐cell STAT3 is required for the maintenance of humoral immunity to LCMV by McIlwain, David R., Grusdat, Melanie, Pozdeev, Vitaly I., Xu, Haifeng C., Shinde, Prashant, Reardon, Colin, Hao, Zhenyue, Beyer, Marc, Bergthaler, Andreas, Häussinger, Dieter, Nolan, Garry P., Lang, Karl S., Lang, Philipp A.

“…STAT3 is a critical transcription factor activated downstream of cytokine signaling and is integral for the function of multiple immune cell types. Human…”
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FSMP-09. FORMATE PROMOTES CANCER CELL INVASION AND METASTASIS VIA CALCIUM SIGNALING by Delbrouck, Catherine, Pozdeev, Vitaly I, Oudin, Anais, Grzyb, Kamil, Neises, Laura, Kiweler, Nicole, Skupin, Alexander, Letellier, Elisabeth, Niclou, Simone P, Meiser, Johannes

“…Abstract Serine catabolism via the folate cycle provides formate that is essential for nucleotide synthesis in proliferating cells. In addition to this…”
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