Search Results - "Poyner, D"

Lifting the lid on GPCRs: the role of extracellular loops by Wheatley, M, Wootten, D, Conner, MT, Simms, J, Kendrick, R, Logan, RT, Poyner, DR, Barwell, J

“…GPCRs exhibit a common architecture of seven transmembrane helices (TMs) linked by intracellular loops and extracellular loops (ECLs). Given their peripheral…”
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Investigating G protein signalling bias at the glucagon‐like peptide‐1 receptor in yeast by Weston, C, Poyner, D, Patel, V, Dowell, S, Ladds, G

“…Background and Purpose The glucagon‐like peptide 1 (GLP‐1) receptor performs an important role in glycaemic control, stimulating the release of insulin. It is…”
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Mapping the Topographic Features of Mining-Related Valley Fills Using Mask R-CNN Deep Learning and Digital Elevation Data by Maxwell, Aaron E., Pourmohammadi, Pariya, Poyner, Joey D.

“…Modern elevation-determining remote sensing technologies such as light-detection and ranging (LiDAR) produce a wealth of topographic information that is…”
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CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin 22–52 , CGRP 8–37 and BIBN4096BS by Hay, D L, Howitt, S G, Conner, A C, Schindler, M, Smith, D M, Poyner, D R

“…Adrenomedullin (AM) has two known receptors formed by the calcitonin receptor‐like receptor (CL) and receptor activity‐modifying protein (RAMP) 2 or 3: We…”
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Receptor activity‐modifying protein‐dependent effects of mutations in the calcitonin receptor‐like receptor: implications for adrenomedullin and calcitonin gene‐related peptide pharmacology by Watkins, H A, Walker, C S, Ly, K N, Bailey, R J, Barwell, J, Poyner, D R, Hay, D L

“…Background and Purpose Receptor activity‐modifying proteins (RAMPs) define the pharmacology of the calcitonin receptor‐like receptor (CLR). The interactions of…”
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International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene-Related Peptides, Adrenomedullin, Amylin, and Calcitonin Receptors by Poyner, David R, Sexton, Patrick M, Marshall, Ian, Smith, David M, Quirion, Remi, Born, Walter, Muff, Roman, Fischer, Jan A, Foord, Steven M

“…The calcitonin family of peptides comprises calcitonin, amylin, two calcitonin gene-related peptides (CGRPs), and adrenomedullin. The first calcitonin receptor…”
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Pharmacology of receptors for calcitonin gene-related peptide and amylin by Poyner, D.

“…Calcitonin gene-related peptide (CGRP), a widespread neuropeptide with multiple actions, has substantial homology with amylin, a peptide implicated in…”
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Calcitonin gene-related peptide: multiple actions, multiple receptors by Poyner, D R

“…Calcitonin gene-related peptide (CGRP) shows diversity both in its effects and its receptors. It is likely to have roles as a neurotransmitter, neuromodulator,…”
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Ligand binding and activation of the CGRP receptor by Conner, A C, Simms, J, Barwell, J, Wheatley, M, Poyner, D R

“…The receptor for CGRP (calcitonin gene-related peptide) is a heterodimer between a GPCR (G-protein-coupled receptor), CLR (calcitonin receptor-like receptor)…”
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Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin by Conner, A C, Simms, J, Hay, D L, Mahmoud, K, Howitt, S G, Wheatley, M, Poyner, D R

“…RAMPs (receptor activity-modifying proteins) are single-pass transmembrane proteins that associate with certain family-B GPCRs (G-protein-coupled receptors)…”
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The pharmacology of CGRP-responsive receptors in cultured and transfected cells by Hay, D.L., Conner, A.C., Howitt, S.G., Takhshid, M.A., Simms, J., Mahmoud, K., Poyner, D.R.

“…Historically, CGRP receptors have been classified as CGRP 1 or CGRP 2 subtypes, chiefly depending on their affinity for the antagonist CGRP 8–37. It has been…”
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Family resemblances? Ligand binding and activation of family A and B G-protein-coupled receptors by Poyner, D R, Wheatley, M

“…In April 2007, the Biochemical Society held a meeting to compare and contrast ligand binding and activation of Family A and B GPCRs (G-protein-coupled…”
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Molecular pharmacology of receptors for calcitonin-gene-related peptide, amylin and adrenomedullin by Poyner, D R

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Interaction of calcitonin-gene-related peptide with its receptors by Conner, A C, Hay, D L, Howitt, S G, Kilk, K, Langel, U, Wheatley, M, Smith, D M, Poyner, D R

“…The receptor for calcitonin-gene-related peptide (CGRP) is a heterodimer formed by calcitonin-receptor-like receptor (CRLR), a type II (family B)…”
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Receptor activity modifying proteins (RAMPs) interact with the VPAC2 receptor and CRF1 receptors and modulate their function by Wootten, D, Lindmark, H, Kadmiel, M, Willcockson, H, Caron, KM, Barwell, J, Drmota, T, Poyner, DR

“…Background and Purpose Although it is established that the receptor activity modifying proteins (RAMPs) can interact with a number of GPCRs, little is known…”
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Inhibition of iron-catalysed hydroxyl radical formation by inositol polyphosphates : a possible physiological function for myo-inositol hexakisphosphate by HAWKINS, P. T, POYNER, D. R, JACKSON, T. R, LETCHER, A. J, LANDER, D. A, IRVINE, R. F

“…1. The ability of myo-inositol polyphosphates to inhibit iron-catalysed hydroxyl radical formation was studied in a hypoxanthine/xanthine oxidase system [Graf,…”
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Characterization of a volume-sensitive chloride current in rat osteoblast-like (ROS 17/2.8) cells by Gosling, M, Smith, J W, Poyner, D R

“…1. During osmotic swelling, cultured osteoblastic cells (ROS 17/2.8) exhibited activation of large amplitude Cl- currents in the whole-cell configuration of…”
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Adrenomedullin: receptor and signal transduction by Smith, D M, Coppock, H A, Withers, D J, Owji, A A, Hay, D L, Choksi, T P, Chakravarty, P, Legon, S, Poyner, D R

“…Adrenomedullin is a vascular tissue peptide and a member of the calcitonin family of peptides, which includes calcitonin, calcitonin-gene-related peptide…”
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Structural determinants for binding to CGRP receptors expressed by human SK‐N‐MC and Col 29 cells: studies with chimeric and other peptides by Poyner, David R, Soomets, Ursel, Howitt, Stephen G, Langel, Ulo

“…Structure‐activity relationships for the binding of human α‐calcitonin gene‐related peptide 8–37 (hαCGRP8–37) have been investigated at the CGRP receptors…”
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Multiple receptors for calcitonin gene‐related peptide and amylin on guinea‐pig ileum and vas deferens by Tomlinson, A. Elaine, Poyner, David R.

“…1 The responses of the electrically stimulated guinea‐pig ileum and vas deferens to human and rat calcitonin gene‐related peptide (CGRP) and amylin were…”
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