Search Results - "Poy, Matthew N."

A skin microRNA promotes differentiation by repressing 'stemness' by Fuchs, Elaine, Yi, Rui, Poy, Matthew N, Stoffel, Markus

“…In stratified epithelial tissues, homeostasis relies on the self-renewing capacity of stem cells located within the innermost basal layer. As basal cells…”
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miR-375 maintains normal pancreatic α- and β-cell mass by Poy, Matthew N, Hausser, Jean, Trajkovski, Mirko, Braun, Matthias, Collins, Stephan, Rorsman, Patrik, Zavolan, Mihaela, Stoffel, Markus

“…Altered growth and development of the endocrine pancreas is a frequent cause of the hyperglycemia associated with diabetes. Here we show that microRNA-375…”
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MicroRNAs: an adaptive mechanism in the pancreatic β-cell…and beyond? by Poy, Matthew N., Ph.D

“…Abstract Recent protocols have been developed to differentiate human stem cells and fibroblasts into insulin-producing cells capable of releasing the hormone…”
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Strategies to determine the biological function of microRNAs by Krützfeldt, Jan, Poy, Matthew N, Stoffel, Markus

“…MicroRNAs (miRNAs) are regulators of gene expression that control many biological processes in development, differentiation, growth and metabolism. Their…”
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Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population by Nimptsch, Katharina, Aydin, Elif Ece, Chavarria, Rafael Francisco Rios, Janke, Jürgen, Poy, Matthew N., Oxvig, Claus, Steinbrecher, Astrid, Pischon, Tobias

“…The pappalysins pregnancy associated plasma protein-A (PAPP-A) and -A2 (PAPP-A2) act as proteinases of insulin-like growth factor-1 (IGF-1) binding proteins,…”
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Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell by Tattikota, Sudhir G., Rathjen, Thomas, McAnulty, Sarah J., Wessels, Hans-Hermann, Akerman, Ildem, van de Bunt, Martijn, Hausser, Jean, Esguerra, Jonathan L.S., Musahl, Anne, Pandey, Amit K., You, Xintian, Chen, Wei, Herrera, Pedro L., Johnson, Paul R., O’Carroll, Donal, Eliasson, Lena, Zavolan, Mihaela, Gloyn, Anna L., Ferrer, Jorge, Shalom-Feuerstein, Ruby, Aberdam, Daniel, Poy, Matthew N.

“…Pancreatic β cells adapt to compensate for increased metabolic demand during insulin resistance. Although the microRNA pathway has an essential role in β cell…”
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SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity by Schmidt, Vanessa, Schulz, Nadja, Yan, Xin, Schürmann, Annette, Kempa, Stefan, Kern, Matthias, Blüher, Matthias, Poy, Matthew N, Olivecrona, Gunilla, Willnow, Thomas E

“…In humans, genetic variation of sortilin-related receptor, L(DLR class) A repeats containing (SORL1), which encodes the intracellular sorting receptor SORLA,…”
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A pancreatic islet-specific microRNA regulates insulin secretion by Stoffel, Markus, Poy, Matthew N, Eliasson, Lena, Krutzfeldt, Jan, Kuwajima, Satoru, Ma, Xiaosong, MacDonald, Patrick E, Pfeffer, Sébastien, Tuschl, Thomas, Rajewsky, Nikolaus, Rorsman, Patrik

“…MicroRNAs (miRNAs) constitute a growing class of non-coding RNAs that are thought to regulate gene expression by translational repression. Several miRNAs in…”
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Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction by Yeh, Yu-Te, Sona, Chandan, Yan, Xin, Li, Yunxiao, Pathak, Adrija, McDermott, Mark I., Xie, Zhigang, Liu, Liangwen, Arunagiri, Anoop, Wang, Yuting, Cazenave-Gassiot, Amaury, Ghosh, Adhideb, von Meyenn, Ferdinand, Kumarasamy, Sivarajan, Najjar, Sonia M., Jia, Shiqi, Wenk, Markus R., Traynor-Kaplan, Alexis, Arvan, Peter, Barg, Sebastian, Bankaitis, Vytas A., Poy, Matthew N.

“…Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer…”
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Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1 by Rathjen, Thomas, Yan, Xin, Kononenko, Natalia L, Ku, Min-Chi, Song, Kun, Ferrarese, Leiron, Tarallo, Valentina, Puchkov, Dmytro, Kochlamazashvili, Gaga, Brachs, Sebastian, Varela, Luis, Szigeti-Buck, Klara, Yi, Chun-Xia, Schriever, Sonja C, Tattikota, Sudhir Gopal, Carlo, Anne Sophie, Moroni, Mirko, Siemens, Jan, Heuser, Arnd, van der Weyden, Louise, Birkenfeld, Andreas L, Niendorf, Thoralf, Poulet, James F A, Horvath, Tamas L, Tschöp, Matthias H, Heinig, Matthias, Trajkovski, Mirko, Haucke, Volker, Poy, Matthew N

“…The precise mechanisms that cause human obesity remain unknown. Here the authors illustrate how increased expression of Cadm1, a mediator of synapse assembly,…”
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Cadm2 regulates body weight and energy homeostasis in mice by Yan, Xin, Wang, Zhen, Schmidt, Vanessa, Gauert, Anton, Willnow, Thomas E, Heinig, Matthias, Poy, Matthew N

“…Obesity is strongly linked to genes regulating neuronal signaling and function, implicating the central nervous system in the maintenance of body weight and…”
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microRNA-184 Induces a Commitment Switch to Epidermal Differentiation by Nagosa, Sara, Leesch, Friederike, Putin, Daria, Bhattacharya, Swarnabh, Altshuler, Anna, Serror, Laura, Amitai-Lange, Aya, Nasser, Waseem, Aberdam, Edith, Rouleau, Matthieu, Tattikota, Sudhir G., Poy, Matthew N., Aberdam, Daniel, Shalom-Feuerstein, Ruby

“…miR-184 is a highly evolutionary conserved microRNA (miRNA) from fly to human. The importance of miR-184 was underscored by the discovery that point mutations…”
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The RhoGAP Stard13 controls insulin secretion through F-actin remodeling by Naumann, Heike, Rathjen, Thomas, Poy, Matthew N, Spagnoli, Francesca M

“…Actin cytoskeleton remodeling is necessary for glucose-stimulated insulin secretion in pancreatic β-cells. A mechanistic understanding of actin dynamics in the…”
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Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes by Sona, Chandan, Yeh, Yu-Te, Patsalos, Andreas, Halasz, Laszlo, Yan, Xin, Kononenko, Natalia L, Nagy, Laszlo, Poy, Matthew N

“…BACKGROUNDPathophysiology of type 1 diabetes (T1D) is illustrated by pancreatic islet infiltration of inflammatory lymphocytes, including CD8+ T cells;…”
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Control of hepatic gluconeogenesis by Argonaute2 by Yan, Xin, Wang, Zhen, Bishop, Christopher A., Weitkunat, Karolin, Feng, Xiao, Tarbier, Marcel, Luo, Jiankai, Friedländer, Marc R., Burkhardt, Ralph, Klaus, Susanne, Willnow, Thomas E., Poy, Matthew N.

“…The liver performs a central role in regulating energy homeostasis by increasing glucose output during fasting. Recent studies on Argonaute2 (Ago2), a key…”
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Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function by Jia, Shiqi, Ivanov, Andranik, Blasevic, Dinko, Müller, Thomas, Purfürst, Bettina, Sun, Wei, Chen, Wei, Poy, Matthew N, Rajewsky, Nikolaus, Birchmeier, Carmen

“…Key transcription factors control the gene expression program in mature pancreatic β‐cells, but their integration into regulatory networks is little…”
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Phosphoinositide 3-Kinase Mediates Enhanced Spontaneous and Agonist-Induced Contraction in Aorta of Deoxycorticosterone Acetate-Salt Hypertensive Rats by Northcott, Carrie A, Poy, Matthew N, Najjar, Sonia M, Watts, Stephanie W

“…ABSTRACT—Arteries from deoxycorticosterone acetate (DOCA)-salt and N-nitro-l-arginine (L-NNA) hypertensive but not normotensive rats develop spontaneous tone…”
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Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice by Kasinathan, Devi, Guo, Zheng, Sarver, Dylan C, Wong, G William, Yun, Shumei, Michels, Aaron W, Yu, Liping, Sona, Chandan, Poy, Matthew N, Golson, Maria L, Fu, Dax

“…Type 1 diabetes (T1D) is an autoimmune disease in which pathogenic lymphocytes target autoantigens expressed in pancreatic islets, leading to the destruction…”
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Combinatorial microRNA target predictions by Rajewsky, Nikolaus, Krek, Azra, Grün, Dominic, Poy, Matthew N, Wolf, Rachel, Rosenberg, Lauren, Epstein, Eric J, MacMenamin, Philip, da Piedade, Isabelle, Gunsalus, Kristin C, Stoffel, Markus

“…MicroRNAs are small noncoding RNAs that recognize and bind to partially complementary sites in the 3′ untranslated regions of target genes in animals and, by…”
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SORCS1 and SORCS3 control energy balance and orexigenic peptide production by Subkhangulova, Aygul, Malik, Anna R, Hermey, Guido, Popp, Oliver, Dittmar, Gunnar, Rathjen, Thomas, Poy, Matthew N, Stumpf, Alexander, Beed, Prateep Sanker, Schmitz, Dietmar, Breiderhoff, Tilman, Willnow, Thomas E

“…SORCS1 and SORCS3 are two related sorting receptors expressed in neurons of the arcuate nucleus of the hypothalamus. Using mouse models with individual or dual…”
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