Search Results - "Pownall, Henry"

Commentary on SSO and other putative inhibitors of FA transport across membranes by CD36 disrupt intracellular metabolism, but do not affect fatty acid translocation by Pownall, Henry J

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High-density lipoproteins, reverse cholesterol transport and atherogenesis by Pownall, Henry J., Rosales, Corina, Gillard, Baiba K., Gotto, Antonio M.

“…Plasma HDL-cholesterol concentrations correlate negatively with the risk of atherosclerotic cardiovascular disease (ASCVD). According to a widely cited model,…”
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Rethinking apolipoprotein A-II in lipid metabolism by Pownall, Henry J

“…Information about the relation of apolipoprotein A-II in lipid metabolism, is presented. Lipoproteins are the major carriers of cholesterol in human plasma…”
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E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis by Ma, Shuangtao, Tian, Xiao Yu, Zhang, Yunrong, Mu, Chaofeng, Shen, Haifa, Bismuth, Jean, Pownall, Henry J., Huang, Yu, Wong, Wing Tak

“…E-selectin is a surface marker of endothelial cell (EC) inflammation, one of the hallmarks of atherogenesis. Thus, we tested the hypothesis that delivery of…”
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Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research by Jarrett, Kelsey E, Lee, Ciaran, De Giorgi, Marco, Hurley, Ayrea, Gillard, Baiba K, Doerfler, Alexandria M, Li, Ang, Pownall, Henry J, Bao, Gang, Lagor, William R

“…OBJECTIVE—Atherosclerosis studies in Ldlr knockout mice require breeding to homozygosity and congenic status on C57BL6/J background, a process that is both…”
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Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function by Gupte, Anisha A., Hamilton, Dale J., Pownall, Henry J.

“…Clinical trials and animal studies have revealed that loss of circulating estrogen induces rapid changes in whole body metabolism, fat distribution, and…”
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ABCA1-Derived Nascent High-Density Lipoprotein-Apolipoprotein AI and Lipids Metabolically Segregate by Xu, Bingqing, Gillard, Baiba K, Gotto, Jr, Antonio M, Rosales, Corina, Pownall, Henry J

“…Reverse cholesterol transport comprises cholesterol efflux from ABCA1-expressing macrophages to apolipoprotein (apo) AI, giving nascent high-density…”
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Association of an Intensive Lifestyle Intervention With Remission of Type 2 Diabetes by Gregg, Edward W, Chen, Haiying, Wagenknecht, Lynne E, Clark, Jeanne M, Delahanty, Linda M, Bantle, John, Pownall, Henry J, Johnson, Karen C, Safford, Monika M, Kitabchi, Abbas E, Pi-Sunyer, F. Xavier, Wing, Rena R, Bertoni, Alain G

“…CONTEXT The frequency of remission of type 2 diabetes achievable with lifestyle intervention is unclear. OBJECTIVE To examine the association of a long-term…”
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High Free Cholesterol Bioavailability Drives the Tissue Pathologies in Scarb1 −/− Mice by Liu, Jing, Gillard, Baiba K., Yelamanchili, Dedipya, Gotto, Antonio M., Rosales, Corina, Pownall, Henry J.

“…Objective: Overall and atherosclerosis-associated mortality is elevated in humans with very high HDL (high-density lipoprotein) cholesterol concentrations…”
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Serum opacity factor rescues fertility among female Scarb1−/− mice by reducing HDL-free cholesterol bioavailability by Rosales, Corina, Yelamanchili, Dedipya, Gillard, Baiba K., Liu, Jing, Gotto, Antonio M., Pownall, Henry J.

“…Human female infertility, 20% of which is idiopathic, is a public health problem for which better diagnostics and therapeutics are needed. A novel cause of…”
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The pathophysiology of excess plasma-free cholesterol by Gillard, Baiba K, Rosales, Corina, Gotto, Jr, Antonio M, Pownall, Henry J

“…Several large studies have shown increased mortality due to all-causes and to atherosclerotic cardiovascular disease. In most clinical settings, plasma…”
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Serum Opacity Factor Normalizes Erythrocyte Morphology in Scarb1-/- Mice in an HDL-Free Cholesterol-Dependent Way by Wang, Ziyi, Yelamanchili, Dedipya, Liu, Jing, Gotto, Antonio M., Rosales, Corina, Gillard, Baiba K., Pownall, Henry J.

“…Compared to wild-type (WT) mice, high-density lipoprotein (HDL)-receptor-deficient (Scarb1-/-) mice have higher plasma levels of free cholesterol (FC)-rich HDL…”
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An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis by Abe, Jun-ichi, Imanishi, Masaki, Li, Shengyu, Zhang, Aijun, Ko, Kyung Ae, Samanthapudi, Venkata S.K., Lee, Ling-Ling, Bojorges, Angelica Paniagua, Gi, Young Jin, Hobbs, Brian P., Deswal, Anita, Herrmann, Joerg, Lin, Steven H., Chini, Eduardo N., Shen, Ying H., Schadler, Keri L., Nguyen, Thi-Hong-Minh, Gupte, Anisha A., Reyes-Gibby, Cielito, Yeung, Sai-Ching J., Abe, Rei J., Olmsted-Davis, Elizabeth A., Krishnan, Sunil, Dantzer, Robert, Palaskas, Nicolas L., Cooke, John P., Pownall, Henry J., Yoshimoto, Momoko, Fujiwara, Keigi, Hamilton, Dale J., Burks, Jared K., Wang, Guangyu, Le, Nhat-Tu, Kotla, Sivareddy

“…ERK5 (extracellular signal-regulated kinase 5) is a dual kinase transcription factor containing an N-terminal kinase domain and a C-terminal transcriptional…”
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Physico-chemical and physiological determinants of lipo-nanoparticle stability by Pownall, Henry J., Liu, Jing, Gillard, Baiba K., Yelamanchili, Dedipya, Rosales, Corina

“…Liposome-based nanoparticles (NPs) comprised mostly of phospholipids (PLs) have been developed to deliver diagnostic and therapeutic agents. Whereas…”
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Association of Weight Loss Maintenance and Weight Regain on 4-Year Changes in CVD Risk Factors: the Action for Health in Diabetes (Look AHEAD) Clinical Trial by Wing, Rena R, Espeland, Mark A, Clark, Jeanne M, Hazuda, Helen P, Knowler, William C, Pownall, Henry J, Unick, Jessica, Wadden, Thomas, Wagenknecht, Lynne

“…Short-term weight loss improves cardiovascular disease (CVD) risk factors. We sought to determine the longer-term effects of maintaining weight loss or,…”
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Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein by Zhang, Lei, Yan, Feng, Zhang, Shengli, Lei, Dongsheng, Charles, M Arthur, Cavigiolio, Giorgio, Oda, Michael, Krauss, Ronald M, Weisgraber, Karl H, Rye, Kerry-Anne, Pownall, Henry J, Qiu, Xiayang, Ren, Gang

“…Optimized negative-staining and cryo–positive staining EM reveals that human cholesteryl ester transfer protein penetrates into HDL and LDL from each distal…”
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Dietary Alcohol and Fat Differentially Affect Plasma Cholesteryl Ester Transfer Activity and Triglycerides in Normo‐ and Hypertriglyceridemic Subjects by Gaubatz, John W., Gillard, Baiba K., Rosales, Corina, Pownall, Henry J.

“…Moderate alcohol consumption is associated with increased plasma high‐density lipoprotein (HDL)‐cholesterol concentrations and reduced risk for cardiovascular…”
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Commentary on SSO and other putative inhibitors of FA transport across membranes by CD36 disrupt intracellular metabolism, but do not affect fatty acid translocation1 by Pownall, Henry J.

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Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease by Jarrett, Kelsey E., Lee, Ciaran M., Yeh, Yi-Hsien, Hsu, Rachel H., Gupta, Rajat, Zhang, Min, Rodriguez, Perla J., Lee, Chang Seok, Gillard, Baiba K., Bissig, Karl-Dimiter, Pownall, Henry J., Martin, James F., Bao, Gang, Lagor, William R.

“…Germline manipulation using CRISPR/Cas9 genome editing has dramatically accelerated the generation of new mouse models. Nonetheless, many metabolic disease…”
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New Insights into the High-Density Lipoprotein Dilemma by Pownall, Henry J, Gotto, Antonio M

“…Although high-density lipoprotein-cholesterol (HDL-C) concentration is a negative risk factor for atherosclerotic cardiovascular disease (CVD), efforts to…”
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