Search Results - "Pownall, HJ"

Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription by CHEN, Chu-Huang, TAO JIANG, YANG, Chao-Yuh, YANG, Jun-Hai, WEI JIANG, LU, Jonathan, MARATHE, Gopal K, POWNALL, Henry J, BALLANTYNE, Christie M, MCINTYRE, Thomas M, HENRY, Philip D

“…Apoptosis of vascular endothelial cells (ECs) can be induced in vitro by experimentally modified LDL. Description of proapoptotic circulating lipoproteins may…”
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Isolation, Characterization, and Functional Assessment of Oxidatively Modified Subfractions of Circulating Low-Density Lipoproteins by Yang, Chao-yuh, Raya, Joe L, Chen, Hsin-Hung, Chen, Chu-Huang, Abe, Yasunori, Pownall, Henry J, Taylor, Addison A, Smith, Charles V

“…OBJECTIVE—Current evidence suggests that oxidatively modified human plasma low-density lipoproteins (ox-LDLs) are proatherogenic and cytotoxic to endothelial…”
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The Effect of Intentional Weight Loss on Fracture Risk in Persons With Diabetes: Results From the Look AHEAD Randomized Clinical Trial by Johnson, Karen C, Bray, George A, Cheskin, Lawrence J, Clark, Jeanne M, Egan, Caitlin M, Foreyt, John P, Garcia, Katelyn R, Glasser, Stephen, Greenway, Frank L, Gregg, Edward W, Hazuda, Helen P, Hergenroeder, Andrea, Hill, James O, Horton, Edward S, Jakicic, John M, Jeffery, Robert W, Kahn, Steven E, Knowler, William C, Lewis, Cora E, Miller, Marsha, Montez, Maria G, Nathan, David M, Patricio, Jennifer L, Peters, Anne L, Pi‐Sunyer, Xavier, Pownall, Henry J, Reboussin, David, Redmon, J Bruce, Steinberg, Helmut, Wadden, Thomas A, Wagenknecht, Lynne E, Wing, Rena R, Womack, Catherine R, Yanovski, Susan Z, Zhang, Ping, Schwartz, Ann V

“…ABSTRACT Intentional weight loss is an important treatment option for overweight persons with type 2 diabetes mellitus (DM), but the effects on long‐term…”
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Troglitazone Antagonizes Tumor Necrosis Factor-α-induced Reprogramming of Adipocyte Gene Expression by Inhibiting the Transcriptional Regulatory Functions of NF-κB by Ruan, Hong, Pownall, Henry J., Lodish, Harvey F.

“…Troglitazone (TGZ), a member of the thiazolidinedione class of anti-diabetic compounds and a peroxisome proliferator activator receptor-γ (PPAR-γ) agonist,…”
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Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease by Rodriguez, Annabelle, Trigatti, Bernardo L, Mineo, Chieko, Knaack, Darcy, Wilkins, John T, Sahoo, Daisy, Asztalos, Bela F, Mora, Samia, Cuchel, Marina, Pownall, Henry J, Rosales, Corina, Bernatchez, Pascal, Ribeiro Martins da Silva, Amanda, Getz, Godfrey S, Barber, Jacob L, Shearer, Gregory C, Zivkovic, Angela M, Tietge, Uwe J.F, Sacks, Frank M, Connelly, Margery A, Oda, Michael N, Davidson, W Sean, Sorci-Thomas, Mary G, Vaisar, Tomas, Ruotolo, Giacomo, Vickers, Kasey C, Martel, Catherine

“…The HDL (high-density lipoprotein) Workshop was established in 2009 as a forum for candid discussions among academic basic scientists, clinical investigators,…”
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Remodeling of Human Plasma Lipoproteins by Detergent Perturbation by Pownall, Henry J

“…Detergent perturbation, the treatment of total human plasma lipoproteins (TLP) with sodium cholate and its subsequent removal, has been used to study…”
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Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients by Morrisett, Joel D., Abdel-Fattah, Ghada, Hoogeveen, Ron, Mitchell, Eddie, Ballantyne, Christie M., Pownall, Henry J., Opekun, Antone R., Jaffe, Jonathon S., Oppermann, Suzanne, Kahan, Barry D.

“…Sirolimus (Rapammune®, rapamycin, RAPA) is a potent immunosuppressive drug that reduces renal transplant rejection. Hyperlipidemia is a significant side effect…”
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Hyperhomocysteinemia accelerates atherosclerosis in cystathionine β-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation by Wang, Hong, Jiang, XiaoHua, Yang, Fan, Gaubatz, John W., Ma, Lang, Magera, Mark J., Yang, XiaoFeng, Berger, Peter B., Durante, William, Pownall, Henry J., Schafer, Andrew I.

“…Although hyperhomocysteinemia is an independent risk factor for cardiovascular disease, a direct role for homocysteine (Hcy) in this disease remains to be…”
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The unique role of apolipoprotein A-I in HDL remodeling and metabolism by Pownall, Henry J, Ehnholm, Christian

“…To rationalize the distinctive biological behavior of apolipoprotein (apo)A-I and apoA-II in light of differences in their respective structures, properties,…”
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Metabolic basis of HIV-lipodystrophy syndrome by Sekhar, Rajagopal V, Jahoor, Farook, White, A Clinton, Pownall, Henry J, Visnegarwala, Fehmida, Rodriguez-Barradas, Maria C, Sharma, Morali, Reeds, Peter J, Balasubramanyam, Ashok

“…Human immunodeficiency virus (HIV)-lipodystrophy syndrome (HLS) is characterized by hypertriglyceridemia, low high-density lipoprotein-cholesterol,…”
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The Lipoprotein and Coronary Atherosclerosis Study (LCAS): Design, methods, and baseline data of a trial of fluvastatin in patients without severe hypercholesterolemia by Stewart West, M., Alan Herd, J, M.Ballantyne, Christie, J. Pownall, Henry, Simpson, Suzanne, Lance Gould, K., M. Gotto, Antonio

“…Few direct clinical data are available regarding whether cholesterol-lowering therapy should be extended to patients with coronary heart disease (CHD) and…”
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Pathophysiology of dyslipidemia and increased cardiovascular risk in HIV lipodystrophy: a model of 'systemic steatosis' by Balasubramanyam, Ashok, Sekhar, Rajagopal V, Jahoor, Farook, Jones, Peter H, Pownall, Henry J

“…This review addresses a syndrome of dyslipidemia and lipodystrophy that has emerged in HIV-infected patients receiving highly active antiretroviral therapy…”
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Role of Oxysterol Structure on the Microdomain-Induced Microsolubilization of Phospholipid Membranes by Apolipoprotein A-I by Massey, John B, Pownall, Henry J

“…Oxygenated derivatives of cholesterol, oxysterols, have different physicochemical properties and three-dimensional shapes. The kinetics of microsolubilization…”
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Severely dysregulated disposal of postprandial triacylglycerols exacerbates hypertriacylglycerolemia in HIV lipodystrophy syndrome by Sekhar, R.V, Jahoor, F, Pownall, H.J, Rehman, K, Gaubatz, J, Iyer, D, Balasubramanyam, A

“…Background: The pathogenesis of hypertriacylglycerolemia, a characteristic feature of HIV lipodystrophy syndrome (HLS), is incompletely understood. One…”
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Characterization of disulfide-linked heterodimers containing apolipoprotein D in human plasma lipoproteins by Blanco-Vaca, F, Via, DP, Yang, CY, Massey, JB, Pownall, HJ

“…Human plasma apolipoprotein (apo) D is a glycoprotein with an apparent molecular weight of 29,000 M(r). It is present, mainly, in high density lipoproteins…”
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Effect of sirolimus on the metabolism of ApoB100-containing lipoproteins in renal transplant patients by HOOGEVEEN, Ron C, BALLANTYNE, Christie M, POWNALL, Henry J, OPEKUN, Antone R, HACHEY, David L, JAFFE, Jonathan S, OPPERMANN, Suzanne, KAHAN, Barry D, MORRISETT, Joel D

“…Sirolimus (Rapamune, rapamycin, RAPA) is a potent immunosuppressive drug that has reduced the rate of acute rejection episodes by more than 40% in phase III…”
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Correlation of serum triglyceride and its reduction by ω-3 fatty acids with lipid transfer activity and the neutral lipid compositions of high-density and low-density lipoproteins by Pownall, Henry J, Brauchi, Danièle, Kilinç, Cumhur, Osmundsen, Karin, Pao, Quein, Payton-Ross, Charlotte, Gotto, Antonio M, Ballantyne, Christie M

“…Serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) concentrations are inversely correlated and mechanistically linked by means of lipid…”
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Enhancing reverse cholesterol transport: the case for phosphatidylcholine therapy by Pownall, Henry J, Ehnholm, Christian

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Overexpression of 1-Acyl-Glycerol-3-Phosphate Acyltransferase-α Enhances Lipid Storage in Cellular Models of Adipose Tissue and Skeletal Muscle by HONG RUAN, POWNALL, Henry J

“…Overexpression of 1-Acyl-Glycerol-3-Phosphate Acyltransferase-α Enhances Lipid Storage in Cellular Models of Adipose Tissue and Skeletal Muscle Hong Ruan and…”
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Interaction effects of high-density lipoprotein metabolism gene variation and alcohol consumption on coronary heart disease risk: The Atherosclerosis Risk in Communities Study by VOLCIK, Kelly, BALLANTYNE, Christie M, POWNALL, Henry J, SHARRETT, A. Richey, BOERWINKLE, Eric

“…Light to moderate alcohol consumption has been widely established to be protective against coronary heart disease (CHD), whereas heavy alcohol consumption has…”
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