Search Results - "Powling, M J"

Measurement of fibrinogen binding to platelets in whole blood by flow cytometry: a micromethod for the detection of platelet activation by Warkentin, T E, Powling, M J, Hardisty, R M

“…Platelet fibrinogen binding in whole blood has been measured in vitro by flow cytometry using a commercially available, fluorescein isothiocyanate…”
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The action of ticlopidine on human platelets. Studies on aggregation, secretion, calcium mobilization and membrane glycoproteins by Hardisty, R M, Powling, M J, Nokes, T J

“…The effects on platelet function of a 5-day course of Ticlopidine (Tcl) have been studied in two groups of volunteers receiving different dosage schedules. Tcl…”
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Grey platelet syndrome: studies on platelet alpha-granules, lysosomes and defective response to thrombin by Srivastava, P C, Powling, M J, Nokes, T J, Patrick, A D, Dawes, J, Hardisty, R M

“…The platelets of a young man with the grey platelet syndrome were severely depleted of all seven alpha-granule proteins assayed as well as partially deficient…”
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A flow cytometric analysis of fibronectin binding to platelets from patients with peripheral vascular disease by Ejim, O S, Powling, M J, Dandona, P, Kernoff, P B, Goodall, A H

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Glycoprotein IIb-IIIa Complex and Ca2+ Influx Into Stimulated Platelets by Powling, Michael J., Hardisty, Roger M.

“…Changes in intracellular Ca2+ concentrations ([Ca2+]i) in platelets stimulated with aggregating agents were measured with the fluorescent indicator dye quin 2…”
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Effects of a monoclonal antibody to glycoprotein IIb/IIIa (P256) and of enzymically derived fragments of P256 on human platelets by Stuttle, A W, Powling, M J, Ritter, J M, Hardisty, R M

“…The anti-platelet monoclonal antibody P256 is currently undergoing development for in vivo detection of thrombus. We have examined the actions of P256 and two…”
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Potentiation by adrenaline of Ca2+ influx and mobilization in stimulated human platelets: dissociation from thromboxane generation and aggregation by Powling, M J, Hardisty, R M

“…In a medium containing 1 mM extracellular Ca2+ (Ca2+o), the prior addition of 0.5 microM adrenaline to quin 2-loaded human platelets increased both the rate…”
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Design of Selective Thrombin Inhibitors Based on the (R)-Phe-Pro-Arg Sequence by Danilewicz, John C, Abel, Stuart M, Brown, Alan D, Fish, Paul V, Hawkeswood, Edward, Holland, Stephen J, James, Keith, McElroy, Andrew B, Overington, John, Powling, Michael J, Rance, David J

“…Potent and selective inhibitors of thrombin were sought based on the (R)-Phe-Pro-Arg sequence. The objective was to generate similar binding interactions to…”
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Differential effects of 12-O-tetradecanoylphorbol 13-acetate on platelet responses to various agonists in the presence and absence of extracellular Ca2 by Powling, M J, Hardisty, R M

“…In the presence of 1 mM extracellular Ca2+ (Ca2+o), incubation of washed, quin 2 loaded platelets with a low concentration (1 nM) of 12-O-tetradecanoylphorbol…”
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Glycoprotein IIb-IIIa complex and Ca2+ influx into stimulated platelets by Powling, MJ, Hardisty, RM

“…Changes in intracellular Ca2+ concentrations [( Ca2+]i) in platelets stimulated with aggregating agents were measured with the fluorescent indicator dye quin…”
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