Search Results - "Powles, Ray L."

Comparison of Preparative Regimens in Transplants for Children With Acute Lymphoblastic Leukemia by DAVIES, S. M, RAMSAY, N. K. C, HENSLEE-DOWNEY, P. J, HERZIG, R. H, HUTCHINSON, R, KEATING, A, LAZARUS, H. M, MILONE, G. A, NEUDORF, S, PEREZ, W. S, POWLES, R. L, PRENTICE, H. G, KLEIN, J. P, SCHILLER, G, SOCIE, G, VOWELS, M, WILEY, J, YEAGER, A, HOROWITZ, M. M, WEISDORF, D. J, BOLWELL, B, CAHN, J.-Y, CAMITTA, B. M, GALE, R. P, GIRALT, S, HEILMANN, C

“…Preparative regimens involving total-body irradiation (TBI) produce significant late toxicities in some children who receive bone marrow transplants, including…”
Get full text

Inhibitory effect of simvastatin on the proliferation of human myeloid leukaemia cells in severe combined immunodeficient (SCID) mice by Clutterbuck, Robyn D., Millar, Barbara C., Powles, Ray L., Newman, Ann, Catovsky, Daniel, Jarman, Michael, Millar, John L.

“…SCID mice were inoculated intravenously with cells from the human HL60 myeloblastic leukaemia cell line and then treated with the 3‐hydroxy‐3‐methylglutaryl…”
Get full text

A Comparison of the Effect of the 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors Simvastatin, Lovastatin and Pravastatin on Leukaemic and Normal Bone Marrow Progenitors by Newman, Ann, Clutterbuck, Robyn D., Powles, Ray L., Catovsky, Daniel, Millar, John L.

“…Simvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and also selectively inhibits the growth of leukaemic progenitor…”
Get full text

Incidence of MLL Rearrangement in Acute Myeloid Leukemia, and a CALM - AF10 Fusion in M4 Type Acute Myeloblastic Leukemia by Abdou, Said M.H., Jadayel, Dalal M., Min, Toon, Swansbury, G. John, Dainton, Melissa G., Jafer, Osman, Powles, Ray L., Catovsky, Daniel

“…To determine the incidence of the mixed lineage leukemia (MLL ) gene rearrangements in acute myeloid leukemia (AML) without cytogenetically-detected 11q23…”
Get full text

Liposomal vincristine for the treatment of human acute lymphoblastic leukaemia in severe combined immunodeficient (SCID) mice by MILLAR, J. L, MILLAR, B. C, POWLES, R. L, STEELE, J. P. C, CLUTTERBUCK, R. D, MITCHELL, P. L. R, COX, G, FORSSEN, E, CATOVSKY, D

“…Non-obese diabetic NOD/SCID mice have been used to grow human leukaemia as a systemic disease. The animals were inoculated with leukaemic cells obtained from a…”
Get full text

Oral Idarubicin as a Single Agent Therapy in Patients with Relapsed or Resistant Multiple Myeloma by Sumpter, Kate, Powles, Ray L, Raje, Noopur, Ramiah, Veshana, Kulkarni, Samar, Treleaven, Jennie, Mainwaring, Paul N

“…The established treatment for multiple myeloma (MM) comprises induction with infusional chemotherapy, high dose chemotherapy (HDC) and autologous…”
Get full text

Outcome of biphenotypic acute leukemia by Killick, S, Matutes, E, Powles, RL, Hamblin, M, Swansbury, J, Treleaven, JG, Zomas, A, Atra, A, Catovsky, D

“…Department of Haematology, St George's Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK. skillick@btinternet.com BACKGROUND AND OBJECTIVE:…”
Get full text

Detection of minimal residual disease in B‐lineage acute lymphoblastic leukaemia by quantitative flow cytometry by Farahat, Nahla, Morilla, Alison, Owusu‐Ankomah, Kwasi, Morilla, Ricardo, Pinkerton, C. Ross, Treleaven, Jennie G., Matutes, Estella, Powles, Ray L., Catovsky, Daniel

“…The clinical significance of detecting minimal residual disease (MRD) in B‐lineage acute lymphoblastic leukaemia (ALL) was evaluated by quantitative flow…”
Get full text

Methotrexate, cyclosporine, or both to prevent graft-versus-host disease after HLA-identical sibling bone marrow transplants for early leukemia ? by RINGDEN, O, HOROWITZ, M. M, RIMM, A. A, ROZMAN, C, SOBOCINSKI, K. A, SPECK, B, ZWAAN, F. E, BORTIN, M. M, SONDEL, P, GALE, R. P, BIGGS, J. C, CHAMPLIN, R. E, DEEG, H. J, DICKE, K, MASAOKA, T, POWLES, R. L

“…Optimal prophylaxis of graft-versus-host disease (GVHD) is controversial. We compared efficacy of three posttransplant immune suppressive regimens in 2,286…”
Get full text

Incidence of MLL Rearrangement in Acute Myeloid Leukemia, and a CALM - AF10 Fusion in M4 Type Acute Myeloblastic Leukemia by Abdou, Said M.H., Jadayel, Dalal M., Min, Toon, Swansbury, G. John, Dainton, Melissa G., Jafer, Osman, Powles, Ray L., Catovsky, Daniel

Get full text

Selective inhibition of primary acute myeloid leukaemia cell growth by simvastatin by Newman, A, Clutterbuck, R D, Powles, R L, Millar, J L

“…Primary human acute myeloid leukaemic (AML) cells from bone marrow (BM) and peripheral (PB), the human myeloblastic leukaemia cell line (HL60) and normal human…”
Get more information

Growth of human T-cell lineage acute leukemia in severe combined immunodeficiency (SCID) mice and non-obese diabetic SCID mice by STEELE, J. P. C, CLUTTERBUCK, R. D, POWLES, R. L, MITCHELL, P. L. R, HORTON, C, MORILLA, R, CATOVSKY, D, MILLAR, J. L

“…Primary leukemic cells from patients with acute lymphoblastic leukemia (ALL) can be injected intravenously into mice with severe combined immunodeficiency…”
Get full text

Interleukin-4 Enhances the Survival of Severe Combined Immunodeficient Mice Engrafted With Human B-Cell Precursor Leukemia by Mitchell, Paul L.R., Clutterbuck, Robyn D., Powles, Ray L., De Lord, Corinne, Morilla, Ricardo, Hiorns, Lynne R., Titley, Jennifer, Catovsky, Daniel, Millar, John L.

“…Human interleukin-4 (hulL-4) has been shown to inhibit the growth in vitro of cells from patients with acute lymphoblastic leukemia (ALL). With the aim of…”
Get full text

Acute myelomonocytic leukemia with t(10;11)(p13;q23): heterogeneity of breakpoints at 11q23 and association with recombinase activation by Height, S E, Dainton, M G, Kearney, L, Swansbury, G J, Matutes, E, Dyer, M J, Treleaven, J G, Powles, R L, Catovsky, D

“…The human trithorax homolog gene (MLL) is directly involved in over 90% of cases of acute leukemia with abnormalities of 11q23. However, involvement of other…”
Get more information

Acute myeloblastic leukaemia--a model for assessing value for money for new treatment programmes by Lobo, P J, Powles, R L, Hanrahan, A, Reynold, D K

“…OBJECTIVE--To measure the effects of changes in treatment of acute myeloblastic leukaemia that may give better value for money. DESIGN--Retrospective analysis…”
Get full text

Methotrexate, Cyclosporins, or Both to Prevent Graft-Versus-Host Disease After HLA-Identical Sibling Bone Marrow Transplants for Early Leukemia? by Ringdén, Olle, Horowitz, Mary M., Sondel, Paul, Gale, Robert Peter, Biggs, James C., Champlin, Richard E., Deeg, H. Joachim, Dicke, Karel, Masaoka, Tohru, Powles, Ray L., Rimm, Alfred A., Rozman, Ciril, Sobocinski, Kathleen A., Speck, Bruno, Zwaan, Ferry E., Bortin, Mortimer M.

“…Optimal prophylaxis of graft-versus-host disease (GVHD) is controversial. We compared efficacy of three posttransplant immune suppressive regimens in 2,286…”
Get full text

Bone-marrow transplant from father to son and subsequent graft from son to father by Powles, R L, Parikh, P M, Helenglass, G, Aboud, H H, Smith, C L, Mrazek, I A, Shepherd, V, Milliken, S T, Treleaven, J, Sharrock, C

“…An 11-year-old boy with acute myeloblastic leukaemia in first remission received an allogeneic mismatched bone-marrow transplant (BMT) from his father in 1979;…”
Get more information

Immunologic maneuvers in the management of acute leukemia by Powles, R L

Get more information

Studies on the development of human acute myeloid leukaemia xenografts in immune-deprived mice: comparison with cells in short-term culture by Clutterbuck, R D, Hills, C A, Hoey, P, Alexander, P, Powles, R L, Millar, J L

“…Human AML cells from the blood of a series of patients have been implanted subcutaneously into mice immune-suppressed by thymectomy and total-body irradiation…”
Get more information

Chimerism in skin of bone marrow transplant recipients by Thomas, J A, Wakeling, W F, Imrie, S F, Sloane, J P, Powles, R L, Lawler, S D

“…Skin biopsies from 3 patients receiving one-haplotype-matched bone marrow grafts have provided a unique opportunity to demonstrate the presence of donor cells…”
Get more information