Search Results - "Powles, Nicola"

Sonic hedgehog Signaling from the Urethral Epithelium Controls External Genital Development by Perriton, Claire L., Powles, Nicola, Chiang, Chin, Maconochie, Mark K., Cohn, Martin J.

“…External genital development begins with formation of paired genital swellings, which develop into the genital tubercle. Proximodistal outgrowth and axial…”
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A cis -acting control region is required exclusively for the tissue-specific imprinting of Gnas by Peters, Jo, Williamson, Christine M, Ball, Simon T, Nottingham, Wade T, Skinner, Judith A, Plagge, Antonius, Turner, Martin D, Powles, Nicola, Hough, Tertius, Papworth, David, Fraser, William D, Maconochie, Mark

“…Genomic imprinting brings about allele-specific silencing according to parental origin. Silencing is controlled by cis-acting regulatory regions that are…”
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Assessment of toxicological effects of blood microsampling in the vehicle dosed adult rat by Powles-Glover, Nicola, Kirk, Sarah, Wilkinson, Catherine, Robinson, Sally, Stewart, Jane

“…•Historically, satellite groups are used for rodent TK profiling.•Vehicle dosed Wistar rats were un-sampled, conventional blood volume, or μ-sampled.•Terminal…”
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Mouse mutagenesis identifies novel roles for left–right patterning genes in pulmonary, craniofacial, ocular, and limb development by Ermakov, Alexander, Stevens, Jonathan L., Whitehill, Elaine, Robson, Joan E., Pieles, Guido, Brooker, Debra, Goggolidou, Paraskevi, Powles‐Glover, Nicola, Hacker, Terry, Young, Stephen R., Dear, Neil, Hirst, Elizabeth, Tymowska‐Lalanne, Zuzanna, Briscoe, James, Bhattacharya, Shoumo, Norris, Dominic P.

“…Vertebrate organs show consistent left–right (L‐R) asymmetry in placement and patterning. To identify genes involved in this process we performed an ENU‐based…”
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Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation by Warr, Nicholas, Powles-Glover, Nicola, Chappell, Anna, Robson, Joan, Norris, Dominic, Arkell, Ruth M.

“…The putative transcription factor ZIC2 is associated with a defect of forebrain development, known as Holoprosencephaly (HPE), in humans and mouse, yet the…”
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ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis by Goggolidou, Paraskevi, Stevens, Jonathan L, Agueci, Francesco, Keynton, Jennifer, Wheway, Gabrielle, Grimes, Daniel T, Patel, Saloni H, Hilton, Helen, Morthorst, Stine K, DiPaolo, Antonella, Williams, Debbie J, Sanderson, Jeremy, Khoronenkova, Svetlana V, Powles-Glover, Nicola, Ermakov, Alexander, Esapa, Chris T, Romero, Rosario, Dianov, Grigory L, Briscoe, James, Johnson, Colin A, Pedersen, Lotte B, Norris, Dominic P

“…Initially identified in DNA damage repair, ATM-interactor (ATMIN) further functions as a transcriptional regulator of lung morphogenesis. Here we analyse three…”
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An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy by Brownbill, Paul, Chernyavsky, Igor, Bottalico, Barbara, Desoye, Gernot, Hansson, Stefan, Kenna, Gerry, Knudsen, Lisbeth E., Markert, Udo R., Powles-Glover, Nicola, Schneider, Henning, Leach, Lopa

“…The human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; a unique organ, species specific in structure and…”
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Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster by Peters, Jo, Williamson, Christine M, Turner, Martin D, Ball, Simon T, Nottingham, Wade T, Glenister, Peter, Fray, Martin, Tymowska-Lalanne, Zuzanna, Plagge, Antonius, Powles-Glover, Nicola, Kelsey, Gavin, Maconochie, Mark

“…Genomic imprinting results in allele-specific silencing according to parental origin. Silencing is brought about by imprinting control regions (ICRs) that are…”
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Prenatal and postnatal development of the mammalian ear by Powles‐Glover, Nicola, Maconochie, Mark

“…The ear can be subdivided into three distinct parts, each with significantly distinct structural and functional differences, the outer, middle, and inner ear,…”
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Time Course for Onset and Recovery from Effects of a Novel Male Reproductive Toxicant: Implications for Apical Preclinical Study Designs by Powles-Glover, Nicola, Mitchard, Terri, Stewart, Jane

“…In the pharmaceutic ICH S5(R2) guidelines for reproductive toxicity testing, a premating dose duration of 14 days is considered sufficient for assessment of…”
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Static respiratory cilia associated with mutations in Dnahc11/DNAH11: A mouse model of PCD by Lucas, Jane S., Adam, Elizabeth C., Goggin, Patricia M., Jackson, Claire L., Powles-Glover, Nicola, Patel, Saloni H, Humphreys, James, Fray, Martin D., Falconnet, Emilie, Blouin, Jean-Louis, Cheeseman, Michael T., Bartoloni, Lucia, Norris, Dominic P., Lackie, Peter M.

“…Primary ciliary dyskinesia (PCD) is an inherited disorder causing significant upper and lower respiratory tract morbidity and impaired fertility. Half of PCD…”
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Editorial by Powles-Glover, Nicola

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Cilia and ciliopathies: Classic examples linking phenotype and genotype—An overview by Powles-Glover, Nicola

“…•The role of cilia in pre and post natal development.•Physiological and dysfunctional role that cilia have in developmental disease.•Dysfunctional cilia can…”
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Safety assessment of herbal drugs in pregnancy by Lewis, Elise, Powles-Glover, Nicola

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Mouse Models of human disease: Potentially of use in DART studies? by Powles-Glover, Nicola

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Editorial by Powles-Glover, Nicola

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Impact of repeated micro and macro blood sampling on clinical chemistry and haematology in rats for toxicokinetic studies by Karp, Natasha A., Coleman, Louise, Cotton, Peter, Powles-Glover, Nicola, Wilson, Amanda

“…Non-clinical rodent safety studies are essential in the development of new medicines to assess for potential adverse effects. Typically, toxicokinetic samples…”
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Cilia and ciliopathies: Classic examples linking phenotype and genotype by Powles-Glover, Nicola

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Biological variability hampers the use of skeletal staining methods in zebrafish embryo developmental toxicity assays by Hoyberghs, Jente, Ball, Jonathan, Trznadel, Maciej, Beekhuijzen, Manon, Burbank, Matthew, Wilhelmi, Pia, Muriana, Arantza, Powles-Glover, Nicola, Letamendia, Ainhoa, Van Cruchten, Steven

“…Zebrafish embryo assays are used by pharmaceutical and chemical companies as new approach methodologies (NAMs) in developmental toxicity screening. Despite an…”
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Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2 by Field, Sarah, Riley, Kerry-Lyn, Grimes, Daniel T, Hilton, Helen, Simon, Michelle, Powles-Glover, Nicola, Siggers, Pam, Bogani, Debora, Greenfield, Andy, Norris, Dominic P

“…In mammals, left-right (L-R) asymmetry is established by posteriorly oriented cilia driving a leftwards laminar flow in the embryonic node, thereby activating…”
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