Search Results - "Powers, T"

Diversity in the origins of proteostasis networks — a driver for protein function in evolution by Powers, Evan T., Balch, William E.

“…Key Points Protein homeostasis (also known as proteostasis) is an integrated system comprising folding chaperones and factors, degradation components and…”
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Targeting protein aggregation for the treatment of degenerative diseases by Eisele, Yvonne S., Monteiro, Cecilia, Fearns, Colleen, Encalada, Sandra E., Wiseman, R. Luke, Powers, Evan T., Kelly, Jeffery W.

“…Key Points The misfolding and/or misassembly of more than 30 human proteins — for example, transthyretin, immunoglobulin light chain, serum amyloid A and…”
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An evolutionary model explaining the Neolithic transition from egalitarianism to leadership and despotism by Powers, Simon T., Lehmann, Laurent

“…The Neolithic was marked by a transition from small and relatively egalitarian groups to much larger groups with increased stratification. But, the dynamics of…”
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Eukaryotic translesion synthesis: Choosing the right tool for the job by Powers, Kyle T., Washington, M. Todd

“…Normal DNA replication is blocked by DNA damage in the template strand. Translesion synthesis is a major pathway for overcoming these replication blocks. In…”
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Biological and chemical approaches to diseases of proteostasis deficiency by Powers, Evan T, Morimoto, Richard I, Dillin, Andrew, Kelly, Jeffery W, Balch, William E

“…Many diseases appear to be caused by the misregulation of protein maintenance. Such diseases of protein homeostasis, or "proteostasis," include…”
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The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug by Johnson, Steven M., Connelly, Stephen, Fearns, Colleen, Powers, Evan T., Kelly, Jeffery W.

“…Transthyretin (TTR) is one of the many proteins that are known to misfold and aggregate (i.e., undergo amyloidogenesis) in vivo. The process of TTR…”
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The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis by Hebert, Daniel N, Lamriben, Lydia, Powers, Evan T, Kelly, Jeffery W

“…Proteins that traffic through the eukaryotic secretory pathway are commonly modified with N-linked carbohydrates. These bulky amphipathic modifications at…”
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How institutions shaped the last major evolutionary transition to large-scale human societies by Powers, Simon T., van Schaik, Carel P., Lehmann, Laurent

“…What drove the transition from small-scale human societies centred on kinship and personal exchange, to large-scale societies comprising cooperation and…”
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Modelling transitions between egalitarian, dynamic leader and absolutist power structures by Bryden, John, Silverman, Eric, Powers, Simon T

“…Human groups show a variety of leadership dynamics ranging from egalitarian groups with no leader, to groups with changing leaders, to absolutist groups with a…”
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Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade by Bulawa, Christine E, Connelly, Stephen, DeVit, Michael, Wang, Lan, Weigel, Charlotte, Fleming, James A, Packman, Jeff, Powers, Evan T, Wiseman, R. Luke, Foss, Theodore R, Wilson, Ian A, Kelly, Jeffery W, Labaudinière, Richard

“…The transthyretin amyloidoses (ATTR) are invariably fatal diseases characterized by progressive neuropathy and/or cardiomyopathy. ATTR are caused by…”
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Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models by Nguyen, Liem H., Robinton, Daisy A., Seligson, Marc T., Wu, Linwei, Li, Lin, Rakheja, Dinesh, Comerford, Sarah A., Ramezani, Saleh, Sun, Xiankai, Parikh, Monisha S., Yang, Erin H., Powers, John T., Shinoda, Gen, Shah, Samar P., Hammer, Robert E., Daley, George Q., Zhu, Hao

“…Lin28a/b are RNA-binding proteins that influence stem cell maintenance, metabolism, and oncogenesis. Poorly differentiated, aggressive cancers often…”
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Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma by Powers, John T., Tsanov, Kaloyan M., Pearson, Daniel S., Roels, Frederik, Spina, Catherine S., Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theißen, Jessica, Tu, Ho-Chou, Han, Areum, Kurek, Kyle C., LaPier, Grace S., Osborne, Jihan K., Ross, Samantha J., Cesana, Marcella, Collins, James J., Berthold, Frank, Daley, George Q.

“…Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN . MYCN is itself a target of let-7 , a tumour suppressor family of microRNAs…”
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Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity by Madhavan, Aparajita, Kok, Bernard P., Rius, Bibiana, Grandjean, Julia M. D., Alabi, Adekunle, Albert, Verena, Sukiasyan, Ara, Powers, Evan T., Galmozzi, Andrea, Saez, Enrique, Wiseman, R. Luke

“…In obesity, signaling through the IRE1 arm of the unfolded protein response exerts both protective and harmful effects. Overexpression of the IRE1-regulated…”
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Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins by Paxman, Ryan, Plate, Lars, Blackwood, Erik A, Glembotski, Chris, Powers, Evan T, Wiseman, R Luke, Kelly, Jeffery W

“…Pharmacologic arm-selective unfolded protein response (UPR) signaling pathway activation is emerging as a promising strategy to ameliorate imbalances in…”
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The LIN28B/let-7 axis is a novel therapeutic pathway in multiple myeloma by Manier, S, Powers, J T, Sacco, A, Glavey, S V, Huynh, D, Reagan, M R, Salem, K Z, Moschetta, M, Shi, J, Mishima, Y, Roche-Lestienne, C, Leleu, X, Roccaro, A M, Daley, G Q, Ghobrial, I M

“…MYC is a major oncogenic driver of multiple myeloma (MM) and yet almost no therapeutic agents exist that target MYC in MM. Here we report that the let-7…”
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The Kinetics of Nucleated Polymerizations at High Concentrations: Amyloid Fibril Formation Near and Above the “Supercritical Concentration” by Powers, Evan T., Powers, David L.

“…The formation of amyloid and other types of protein fibrils is thought to proceed by a nucleated polymerization mechanism. One of the most important features…”
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Autonomous motivation and support flourishes for individuals higher in collaborative personality factors: Agreeableness, assisted autonomy striving, and secure attachment by Levine, S. L., Milyavskaya, M., Powers, T. A., Holding, A. C., Koestner, R.

“…Introduction Individuals who strive autonomously for their goals, and who perceive autonomy supportive environments are more successful during goal pursuit…”
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MALDI Mass Spectrometry Imaging of N-Linked Glycans in Cancer Tissues by Drake, R R, Powers, T W, Jones, E E, Bruner, E, Mehta, A S, Angel, P M

“…Glycosylated proteins account for a majority of the posttranslation modifications of cell surface, secreted, and circulating proteins. Within the tumor…”
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Current and future treatment of amyloid diseases by Ankarcrona, M., Winblad, B., Monteiro, C., Fearns, C., Powers, E. T., Johansson, J., Westermark, G. T., Presto, J., Ericzon, B.‐G., Kelly, J. W.

“…There are more than 30 human proteins whose aggregation appears to cause degenerative maladies referred to as amyloid diseases or amyloidoses. These disorders…”
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Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation by Plate, Lars, Cooley, Christina B, Chen, John J, Paxman, Ryan J, Gallagher, Ciara M, Madoux, Franck, Genereux, Joseph C, Dobbs, Wesley, Garza, Dan, Spicer, Timothy P, Scampavia, Louis, Brown, Steven J, Rosen, Hugh, Powers, Evan T, Walter, Peter, Hodder, Peter, Wiseman, R Luke, Kelly, Jeffery W

“…Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein…”
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