Search Results - "Powers, Randall K"

Nonlinear Input-Output Functions of Motoneurons by Binder, Marc D, Powers, Randall K, Heckman, C J

“…All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor…”
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Synaptic control of the shape of the motoneuron pool input-output function by Powers, Randall K, Heckman, Charles J

“…Although motoneurons have often been considered to be fairly linear transducers of synaptic input, recent evidence suggests that strong persistent inward…”
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The potential for understanding the synaptic organization of human motor commands via the firing patterns of motoneurons by Johnson, Michael D, Thompson, Christopher K, Tysseling, Vicki M, Powers, Randall K, Heckman, Charles J

“…Motoneurons are unique in being the only neurons in the CNS whose firing patterns can be easily recorded in human subjects. This is because of the one-to-one…”
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Postinhibitory excitation in motoneurons can be facilitated by hyperpolarization-activated inward currents: A simulation study by Schmid, Laura, Klotz, Thomas, Röhrle, Oliver, Powers, Randall K, Negro, Francesco, Yavuz, Utku Ş

“…Postinhibitory excitation is a transient overshoot of a neuron's baseline firing rate following an inhibitory stimulus and can be observed in vivo in human…”
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Axon initial segment geometry in relation to motoneuron excitability by Rotterman, Travis M, Carrasco, Darío I, Housley, Stephen N, Nardelli, Paul, Powers, Randall K, Cope, Timothy C

“…The axon initial segment (AIS) responsible for action potential initiation is a dynamic structure that varies and changes together with neuronal excitability…”
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Impact of parameter selection on estimates of motoneuron excitability using paired motor unit analysis by Hassan, Altamash, Thompson, Christopher K, Negro, Francesco, Cummings, Mark, Powers, Randall K, Heckman, C J, Dewald, Julius P A, McPherson, Laura Miller

“…Noninvasive estimation of motoneuron excitability in human motoneurons is achieved through a paired motor unit analysis (ΔF) that quantifies hysteresis in the…”
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Multimodal parameter spaces of a complex multi-channel neuron model by Wang, Y Curtis, Rudi, Johann, Velasco, James, Sinha, Nirvik, Idumah, Gideon, Powers, Randall K, Heckman, Charles J, Chardon, Matthieu K

“…One of the most common types of models that helps us to understand neuron behavior is based on the Hodgkin-Huxley ion channel formulation (HH model). A major…”
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Contribution of intrinsic properties and synaptic inputs to motoneuron discharge patterns: a simulation study by Powers, Randall K, Elbasiouny, Sherif M, Rymer, W Zev, Heckman, C J

“…Motoneuron discharge patterns reflect the interaction of synaptic inputs with intrinsic conductances. Recent work has focused on the contribution of…”
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The effects of membrane potential oscillations on the excitability of rat hypoglossal motoneurons by Zhang, Qiang, Dai, Yue, Zhou, Junya, Ge, Renkai, Hua, Yiyun, Powers, Randall K., Binder, Marc D.

“…Oscillations in membrane potential induced by synaptic inputs and intrinsic ion channel activity play a role in regulating neuronal excitability, but the…”
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Robust and accurate decoding of motoneuron behaviour and prediction of the resulting force output by Thompson, Christopher K., Negro, Francesco, Johnson, Michael D., Holmes, Matthew R., McPherson, Laura Miller, Powers, Randall K., Farina, Dario, Heckman, Charles J.

“…Key points The spinal alpha motoneuron is the only cell in the human CNS whose discharge can be routinely recorded in humans. We have reengineered motor unit…”
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Contribution of intrinsic motoneuron properties to discharge hysteresis and its estimation based on paired motor unit recordings: a simulation study by Powers, Randall K, Heckman, C J

“…Motoneuron activity is strongly influenced by the activation of persistent inward currents (PICs) mediated by voltage-gated sodium and calcium channels…”
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Imbalanced Subthreshold Currents Following Sepsis and Chemotherapy: A Shared Mechanism Offering a New Therapeutic Target? by Rich, Mark M., Housley, Stephen N., Nardelli, Paul, Powers, Randall K., Cope, Timothy C.

“…Both sepsis and treatment of cancer with chemotherapy are known to cause neurologic dysfunction. The primary defects seen in both groups of patients are…”
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Relationship between the time course of the afterhyperpolarization and discharge variability in cat spinal motoneurones by Powers, Randall K., Binder, Marc D., Matthews, Peter B. C.

“…We elicited repetitive discharges in cat spinal motoneurones by injecting noisy current waveforms through a microelectrode to study the relationship between…”
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Relationship Between Simulated Common Synaptic Input and Discharge Synchrony in Cat Spinal Motoneurons by Binder, Marc D, Powers, Randall K

“…Department of Physiology and Biophysics, School of Medicine, University of Washington, Seattle, Washington 98195 Binder, Marc D. and Randall K. Powers…”
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Contribution of Persistent Sodium Currents to Spike-Frequency Adaptation in Rat Hypoglossal Motoneurons by Zeng, Jinsong, Powers, Randall K, Newkirk, Gregory, Yonkers, Marc, Binder, Marc D

“…Department of Physiology and Biophysics, University of Washington, School of Medicine, Seattle, Washington Submitted 13 August 2004; accepted in final form 7…”
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A geometric approach to quantifying the neuromodulatory effects of persistent inward currents on individual motor unit discharge patterns by Beauchamp, James A, Pearcey, Gregory E P, Khurram, Obaid U, Chardon, Matthieu, Wang, Y Curtis, Powers, Randall K, Dewald, Julius P A, Heckman, C J

“…All motor commands flow through motoneurons, which entrain control of their innervated muscle fibers, forming a motor unit (MU). Owing to the high fidelity of…”
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Supercomputer framework for reverse engineering firing patterns of neuron populations to identify their synaptic inputs by Chardon, Matthieu K, Wang, Y Curtis, Garcia, Marta, Besler, Emre, Beauchamp, J Andrew, D'Mello, Michael, Powers, Randall K, Heckman, Charles J

“…In this study, we develop new reverse engineering (RE) techniques to identify the organization of the synaptic inputs generating firing patterns of populations…”
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Summation of Effective Synaptic Currents and Firing Rate Modulation in Cat Spinal Motoneurons by Powers, Randall K, Binder, Marc D

“…Department of Physiology and Biophysics, School of Medicine, University of Washington, Seattle, Washington 98195 Powers, Randall K. and Marc D. Binder…”
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Modulation of motoneuron firing by recurrent inhibition in the adult rat in vivo by Obeidat, Ahmed Z, Nardelli, Paul, Powers, Randall K, Cope, Timothy C

“…Recent reports show that synaptic inhibition can modulate postsynaptic spike timing without having strong effects on firing rate. Thus synaptic inhibition can…”
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Estimation of the Contribution of Intrinsic Currents to Motoneuron Firing Based on Paired Motoneuron Discharge Records in the Decerebrate Cat by Powers, Randall K, Nardelli, Paul, Cope, T. C

“…1 Department of Physiology and Biophysics, University of Washington, School of Medicine, Seattle, Washington; and 2 Department of Neuroscience, Cell Biology…”
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