Search Results - "Powers, John T."

Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models by Nguyen, Liem H., Robinton, Daisy A., Seligson, Marc T., Wu, Linwei, Li, Lin, Rakheja, Dinesh, Comerford, Sarah A., Ramezani, Saleh, Sun, Xiankai, Parikh, Monisha S., Yang, Erin H., Powers, John T., Shinoda, Gen, Shah, Samar P., Hammer, Robert E., Daley, George Q., Zhu, Hao

“…Lin28a/b are RNA-binding proteins that influence stem cell maintenance, metabolism, and oncogenesis. Poorly differentiated, aggressive cancers often…”
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Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma by Powers, John T., Tsanov, Kaloyan M., Pearson, Daniel S., Roels, Frederik, Spina, Catherine S., Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theißen, Jessica, Tu, Ho-Chou, Han, Areum, Kurek, Kyle C., LaPier, Grace S., Osborne, Jihan K., Ross, Samantha J., Cesana, Marcella, Collins, James J., Berthold, Frank, Daley, George Q.

“…Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN . MYCN is itself a target of let-7 , a tumour suppressor family of microRNAs…”
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LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency by Tsanov, Kaloyan M., Pearson, Daniel S., Wu, Zhaoting, Han, Areum, Triboulet, Robinson, Seligson, Marc T., Powers, John T., Osborne, Jihan K., Kane, Susan, Gygi, Steven P., Gregory, Richard I., Daley, George Q.

“…Daley and colleagues report that MAPK signalling controls pluripotency in embryonic stem cells and during somatic cell reprogramming by enhancing the stability…”
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The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming by Unternaehrer, Juli J., Zhao, Rui, Kim, Kitai, Cesana, Marcella, Powers, John T., Ratanasirintrawoot, Sutheera, Onder, Tamer, Shibue, Tsukasa, Weinberg, Robert A., Daley, George Q.

“…Reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) entails a mesenchymal to epithelial transition (MET). While attempting to dissect the…”
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Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival by Jones, Matthew R, Blahna, Matthew T, Kozlowski, Elyse, Matsuura, Kori Y, Ferrari, Joseph D, Morris, Samantha A, Powers, John T, Daley, George Q, Quinton, Lee J, Mizgerd, Joseph P

“…The Zcchc11 enzyme is implicated in microRNA (miRNA) regulation. It can uridylate let-7 precursors to decrease quantities of the mature miRNA in embryonic stem…”
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ATM Promotes Apoptosis and Suppresses Tumorigenesis in Response to Myc by Pusapati, Raju V., Rounbehler, Robert J., Hong, SungKi, Powers, John T., Yan, Mingshan, Kiguchi, Kaoru, McArthur, Mark J., Wong, Paul K., Johnson, David G.

“…Overexpression of the c-myc oncogene contributes to the development of a significant number of human cancers. In response to deregulated Myc activity, the p53…”
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E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis by Powers, John T, Hong, SungKi, Mayhew, Christopher N, Rogers, Pamela M, Knudsen, Erik S, Johnson, David G

“…The p53 tumor suppressor protein is phosphorylated and activated by several DNA damage-inducible kinases, such as ATM, and is a key effector of the DNA damage…”
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Oncogenes and the DNA Damage Response: Myc and E2F1 Engage the ATM Signaling Pathway to Activate p53 and Induce Apoptosis by Hong, Sungki, Pusapati, Raju V., Powers, John T., Johnson, David G.

“…Activation of the ATM DNA damage response pathway is commonly observed in avariety of early-stage neoplasias. It has been proposed that this checkpoint…”
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Lin28 promotes transformation and is associated with advanced human malignancies by O'Sullivan, Maureen, Phillips, Letha A, Viswanathan, Srinivas R, Daley, George Q, Llovet, Josep M, Einhorn, William, Toffanin, Sara, Hughes, Timothy P, Lockhart, Victoria L, Powers, John T, Mermel, Craig H, Meyerson, Matthew, Shah, Samar P, Sorensen, Poul H, Radich, Jerald, Hoshida, Yujin, Lu, Jun, Azam, Mohammad, Ng, Tony L, Beroukhim, Rameen, Teixeira, Jose, Mullighan, Charles G, Golub, Todd R, Tanwar, Pradeep S

“…Multiple members of the let-7 family of miRNAs are often repressed in human cancers, thereby promoting oncogenesis by derepressing targets such as HMGA2, K-Ras…”
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Liver cancer initiation requires translational activation by an oncofetal regulon involving LIN28 proteins by Hsieh, Meng-Hsiung, Wei, Yonglong, Li, Lin, Nguyen, Liem H, Lin, Yu-Hsuan, Yong, Jung M, Sun, Xuxu, Wang, Xun, Luo, Xin, Knutson, Sarah K, Bracken, Christina, Daley, George Q, Powers, John T, Zhu, Hao

“…It is unknown which posttranscriptional regulatory mechanisms are required for oncogenic competence. Here, we show that the LIN28 family of RNA-binding…”
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LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors by Tao, Ting, Shi, Hui, Mariani, Luca, Abraham, Brian J., Durbin, Adam D., Zimmerman, Mark W., Powers, John T., Missios, Pavlos, Ross, Kenneth N., Perez-Atayde, Antonio R., Bulyk, Martha L., Young, Richard A., Daley, George Q., Look, A. Thomas

“…LIN28B is highly expressed in neuroblastoma and promotes tumorigenesis, at least, in part, through inhibition of let-7 micro-RNA biogenesis. Here, we report…”
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LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy by Missios, Pavlos, da Rocha, Edroaldo Lummertz, Pearson, Daniel S, Philipp, Julia, Aleman, Maria M, Pirouz, Mehdi, Farache, Dorian, Franses, Joseph W, Kubaczka, Caroline, Tsanov, Kaloyan M, Jha, Deepak K, Pepe-Mooney, Brian, Powers, John T, Gregory, Richard I, Lee, Amy Sy, Dominguez, Daniel, Ting, David T, Daley, George Q

“…High expression of LIN28B is associated with aggressive malignancy and poor survival. Here, probing MYCN-amplified neuroblastoma as a model system, we showed…”
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ARF Differentially Modulates Apoptosis Induced by E2F1 and Myc by Russell, Jamie L., Powers, John T., Rounbehler, Robert J., Rogers, Pamela M., Conti, Claudio J., Johnson, David G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Unsaturated Fatty Acid Synthesis Is Associated with Worse Survival and Is Differentially Regulated by MYCN and Tumor Suppressor microRNAs in Neuroblastoma by Sheeter, Dennis A, Garza, Secilia, Park, Hui Gyu, Benhamou, Lorraine-Rana E, Badi, Niharika R, Espinosa, Erika C, Kothapalli, Kumar S D, Brenna, J Thomas, Powers, John T

“…amplification ( ) and disruption of tumor suppressor microRNA (TSmiR) function are key drivers of poor outcomes in neuroblastoma (NB). While MYCN and TSmiRs…”
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Abstract LB-165: Multiple mechanisms disrupt let-7 miRNA biogenesis and function in neuroblastoma by Powers, John T., Tsanov, Kaloyan, Roels, Frederik, Spina, Catherine, Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Pearson, Daniel, Theißen, Jessica, Tu, Ho-Chou, LaPier, Grace, Osborne, Jihan, Ross, Samantha, Collins, James, Berthold, Frank, Daley, George

“…Abstract The let-7 microRNA family are known tumor suppressors often deregulated in cancer, yet the underlying mechanisms of let-7 disruption remain poorly…”
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AP24163 Inhibits the Gatekeeper Mutant of BCR-ABL and Suppresses In vitro Resistance by Azam, Mohammad, Powers, John T, Einhorn, William, Huang, Wei-Sheng, Shakespeare, William C, Zhu, Xiaotian, Dalgarno, David, Clackson, Tim, Sawyer, Tomi K, Daley, George Q

“…Mutation in the ABL kinase domain is the principal mechanism of imatinib resistance in patients with chronic myelogenous leukaemia. The second generation…”
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Student Veterans by Darcy, Monica G., Powers, John T.

“…This article explores advantages and obstacles student veterans face in transitioning to an academic setting. Focus groups were conducted with student veterans…”
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The LIN28B/let-7 axis is a novel therapeutic pathway in multiple myeloma by Manier, S, Powers, J T, Sacco, A, Glavey, S V, Huynh, D, Reagan, M R, Salem, K Z, Moschetta, M, Shi, J, Mishima, Y, Roche-Lestienne, C, Leleu, X, Roccaro, A M, Daley, G Q, Ghobrial, I M

“…MYC is a major oncogenic driver of multiple myeloma (MM) and yet almost no therapeutic agents exist that target MYC in MM. Here we report that the let-7…”
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Abstract LB295: Unsaturated fatty acid synthesis is associated with poor prognosis and is differentially regulated by MYCN and tumor suppressor microRNAs in neuroblastoma by Sheeter, Dennis A., Garza, Secilia, Park, Hui Gyu, Benhamou, Lorraine-Rana, Badi, Nikki R., Espinosa, Erika C., Kothapalli, Kumar, Brenna, J. Thomas, Powers, John T.

“…Abstract Dysregulated metabolism is a hallmark of cancer. While the role of glucose metabolism in cancer has been extensively studied, relatively little has…”
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Abstract 144: Sex bias in neuroblastoma: Worse outcomes for female patients are associated with dysregulation of DLK1 and H19 by Raleigh, Mariya, Patel, Vishwa, Benhamou, Lorraine R., Shen, Xin, Sheeter, Dennis A., Espinosa, Erika C., Badi, Niharika Reddy, Calvert, Chase, Bourne, Garrett, Powers, John T.

“…Abstract Neuroblastoma (NB) is a devastating neural crest-derived tumor primarily affects children under five. Forty percent of NB patients are classified as…”
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