Search Results - "Powers, Jeffery C."

The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense by Horton, Julie L, Davidson, Michael T, Kurishima, Clara, Vega, Rick B, Powers, Jeffery C, Matsuura, Timothy R, Petucci, Christopher, Lewandowski, E Douglas, Crawford, Peter A, Muoio, Deborah M, Recchia, Fabio A, Kelly, Daniel P

“…Evidence has emerged that the failing heart increases utilization of ketone bodies. We sought to determine whether this fuel shift is adaptive. Mice rendered…”
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Acute and Chronic Increases of Circulating FSTL1 Normalize Energy Substrate Metabolism in Pacing-Induced Heart Failure by Seki, Mitsuru, Powers, Jeffery C, Maruyama, Sonomi, Zuriaga, Maria A, Wu, Chia-Ling, Kurishima, Clara, Kim, Lydia, Johnson, Jesse, Poidomani, Anthony, Wang, Tao, Muñoz, Eric, Rajan, Sudarsan, Park, Joon Y, Walsh, Kenneth, Recchia, Fabio A

“…FSTL1 (follistatin-like protein 1) is an emerging cardiokine/myokine that is upregulated in heart failure (HF) and is found to be cardioprotective in animal…”
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Flow pattern–dependent mitochondrial dynamics regulates the metabolic profile and inflammatory state of endothelial cells by Hong, Soon-Gook, Shin, Junchul, Choi, Soo Young, Powers, Jeffery C., Meister, Benjamin M., Sayoc, Jacqueline, Son, Jun Seok, Tierney, Ryan, Recchia, Fabio A., Brown, Michael D., Yang, Xiaofeng, Park, Joon-Young

“…Endothelial mitochondria play a pivotal role in maintaining endothelial cell (EC) homeostasis through constantly altering their size, shape, and intracellular…”
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Intracoronary Cytoprotective Gene Therapy by Woitek, Felix, MD, Zentilin, Lorena, PhD, Hoffman, Nicholas E., PhD, Powers, Jeffery C., BS, Ottiger, Isabel, BA, Parikh, Suraj, BS, Kulczycki, Anna M., BS, Hurst, Marykathryn, MS, Ring, Nadja, BS, Wang, Tao, MD, PhD, Shaikh, Farah, MD, Gross, Polina, BS, Singh, Harinder, PhD, Kolpakov, Mikhail A., MD, PhD, Linke, Axel, MD, Houser, Steven R., PhD, Rizzo, Victor, PhD, Sabri, Abdelkarim, PhD, Madesh, Muniswamy, PhD, Giacca, Mauro, MD, PhD, Recchia, Fabio A., MD, PhD

“…Abstract Background Vascular endothelial growth factor (VEGF)-B activates cytoprotective/antiapoptotic and minimally angiogenic mechanisms via VEGF receptors…”
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Intracoronary Cytoprotective Gene Therapy: A Study of VEGF-B167 in a Pre-Clinical Animal Model of Dilated Cardiomyopathy by Woitek, Felix, Zentilin, Lorena, Hoffman, Nicholas E, Powers, Jeffery C, Ottiger, Isabel, Parikh, Suraj, Kulczycki, Anna M, Hurst, Marykathryn, Ring, Nadja, Wang, Tao, Shaikh, Farah, Gross, Polina, Singh, Harinder, Kolpakov, Mikhail A, Linke, Axel, Houser, Steven R, Rizzo, Victor, Sabri, Abdelkarim, Madesh, Muniswamy, Giacca, Mauro, Recchia, Fabio A

“…Vascular endothelial growth factor (VEGF)-B activates cytoprotective/antiapoptotic and minimally angiogenic mechanisms via VEGF receptors. Therefore, VEGF-B…”
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Differential microRNA-21 and microRNA-221 Upregulation in the Biventricular Failing Heart Reveals Distinct Stress Responses of Right Versus Left Ventricular Fibroblasts by Powers, Jeffery C., Sabri, Abdelkarim, Al-Bataineh, Dalia, Chotalia, Dhruv, Guo, Xinji, Tsipenyuk, Florence, Berretta, Remus, Kavitha, Pavithra, Gopi, Heramba, Houser, Steven R., Khan, Mohsin, Tsai, Emily J., Recchia, Fabio A.

“…The failing right ventricle (RV) does not respond like the left ventricle (LV) to guideline-directed medical therapy of heart failure, perhaps due to…”
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Class I Histone Deacetylase Inhibition for the Treatment of Sustained Atrial Fibrillation by Seki, Mitsuru, LaCanna, Ryan, Powers, Jeffery C, Vrakas, Christine, Liu, Fang, Berretta, Remus, Chacko, Geena, Holten, John, Jadiya, Pooja, Wang, Tao, Arkles, Jeffery S, Copper, Joshua M, Houser, Steven R, Huang, Jianhe, Patel, Vickas V, Recchia, Fabio A

“…Current therapies are less effective for treating sustained/permanent versus paroxysmal atrial fibrillation (AF). We and others have previously shown that…”
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DOSE-DEPENDENCY AND EFFECTIVENESS OF CARDIAC GENE THERAPY WITH VEGF-B IN A PRE-CLINICAL MODEL OF DILATED CARDIOMYOPATHY by Woitek, Felix J, Zentilin, Lorena, Hurst, Marykathryn, Powers, Jeffery C, Ottiger, Isabel, Kulczycki, Anna M, Hoffmann, Nicholas E, Ring, Nadja, Lam, Amy, Ly, Lien P, Sabri, Abdelkarim, Madesh, Muniswamy, Houser, Steven R, Giacca, Mauro, Recchia, Fabio A

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Acute and Chronic Increases of Circulating Follistatin-like Protein 1 Normalize Energy Substrate Metabolism in Pacing-Induced Heart Failure by Seki, Mitsuru, Powers, Jeffery C., Maruyama, Sonomi, Zuriaga, Maria A., Wu, Chia-Ling, Kurishima, Clara, Kim, Lydia, Johnson, Jesse, Poidomani, Anthony, Wang, Tao, Muñoz, Eric, Rajan, Sudarsan, Park, Joon Y., Walsh, Kenneth, Recchia, Fabio A.

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microRNA-21 as a pro-fibrotic mediator in right ventricular failure by Powers, Jeffery C

“…Historical emphasis on the left ventricle (LV) has left clinicians with a lack of efficacious right ventricle (RV)-specific therapies, and classical…”
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Abstract 14219: Enhancing Cardiac Beta-Hydroxybutyrate Consumption Halts the Progression From Compensated to Decompensated Heart Failure in Dogs With Tachypacing-Induced Dilated Cardiomyopathy by Kurishima, Clara, Powers, Jeffery C, Seki, Mitsuru, Kavitha, Pavithra, Tsipenyuk, Florence, Cunningham, Keely, Gopi, Heramba V, Matsuura, Timothy, Kelly, Daniel P, Recchia, Fabio A

“…IntroductionRecent Evidence indicates that circulating ketone bodies serve as an alternative myocardial substrate in heart failure (HF).HypothesisWe tested the…”
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