Search Results - "Powers, Andrew F."

OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy by Shammas, Mario K, Huang, Xiaoping, Wu, Beverly P, Fessler, Evelyn, Song, Insung, Randolph, Nicholas P, Li, Yan, Bleck, Christopher Ke, Springer, Danielle A, Fratter, Carl, Barbosa, Ines A, Powers, Andrew F, Quirós, Pedro M, Lopez-Otin, Carlos, Jae, Lucas T, Poulton, Joanna, Narendra, Derek P

“…Mitochondrial stress triggers a response in the cell's mitochondria and nucleus, but how these stress responses are coordinated in vivo is poorly understood…”
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The Ndc80 Kinetochore Complex Forms Load-Bearing Attachments to Dynamic Microtubule Tips via Biased Diffusion by Powers, Andrew F., Franck, Andrew D., Gestaut, Daniel R., Cooper, Jeremy, Gracyzk, Beth, Wei, Ronnie R., Wordeman, Linda, Davis, Trisha N., Asbury, Charles L.

“…Kinetochores couple chromosomes to the assembling and disassembling tips of microtubules, a dynamic behavior that is fundamental to mitosis in all eukaryotes…”
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Tension applied through the Dam1 complex promotes microtubule elongation providing a direct mechanism for length control in mitosis by Gestaut, Daniel R, Franck, Andrew D, Gonen, Tamir, Powers, Andrew F, Davis, Trisha N, Asbury, Charles L

“…In dividing cells, kinetochores couple chromosomes to the tips of growing and shortening microtubule fibres and tension at the kinetochore-microtubule…”
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The Dam1 Kinetochore Complex Harnesses Microtubule Dynamics to Produce Force and Movement by Asbury, Charles L., Gestaut, Daniel R., Powers, Andrew F., Franck, Andrew D., Davis, Trisha N.

“…Kinetochores remain attached to microtubule (MT) tips during mitosis even as the tips assemble and disassemble under their grip, allowing filament dynamics to…”
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Prevention and regression of megamitochondria and steatosis by blocking mitochondrial fusion in the liver by Yamada, Tatsuya, Murata, Daisuke, Kleiner, David E., Anders, Robert, Rosenberg, Avi Z., Kaplan, Jeffrey, Hamilton, James P., Aghajan, Mariam, Levi, Moshe, Wang, Nae-Yuh, Dawson, Ted M., Yanagawa, Toru, Powers, Andrew F., Iijima, Miho, Sesaki, Hiromi

“…Non-alcoholic steatohepatitis (NASH) is a most common chronic liver disease that is manifested by steatosis, inflammation, fibrosis, and tissue damage…”
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Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1 by Pirie, Elaine, Ray, Shayoni, Pan, Calvin, Fu, Wuxia, Powers, Andrew F, Polikoff, Danielle, Miller, Colton M, Kudrna, Katrina M, Harris, Edward N, Lusis, Aldons J, Crooke, Rosanne M, Lee, Richard G

“…Antisense oligonucleotides (ASOs) have demonstrated variation of efficacy in patient populations. This has prompted our investigation into the contribution of…”
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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo by Dowdle, William E., Nyfeler, Beat, Nagel, Jane, Elling, Robert A., Liu, Shanming, Triantafellow, Ellen, Menon, Suchithra, Wang, Zuncai, Honda, Ayako, Pardee, Gwynn, Cantwell, John, Luu, Catherine, Cornella-Taracido, Ivan, Harrington, Edmund, Fekkes, Peter, Lei, Hong, Fang, Qing, Digan, Mary Ellen, Burdick, Debra, Powers, Andrew F., Helliwell, Stephen B., D’Aquin, Simon, Bastien, Julie, Wang, Henry, Wiederschain, Dmitri, Kuerth, Jenny, Bergman, Philip, Schwalb, David, Thomas, Jason, Ugwonali, Savuth, Harbinski, Fred, Tallarico, John, Wilson, Christopher J., Myer, Vic E., Porter, Jeffery A., Bussiere, Dirksen E., Finan, Peter M., Labow, Mark A., Mao, Xiaohong, Hamann, Lawrence G., Manning, Brendan D., Valdez, Reginald A., Nicholson, Thomas, Schirle, Markus, Knapp, Mark S., Keaney, Erin P., Murphy, Leon O.

“…Cells rely on autophagy to clear misfolded proteins and damaged organelles to maintain cellular homeostasis. In this study we use the new autophagy inhibitor…”
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Tension directly stabilizes reconstituted kinetochore-microtubule attachments by Asbury, Charles L, Biggins, Sue, Akiyoshi, Bungo, Sarangapani, Krishna K, Powers, Andrew F, Nelson, Christian R, Reichow, Steve L, Arellano-Santoyo, Hugo, Gonen, Tamir, Ranish, Jeffrey A

“…Kinetochores are macromolecular machines that couple chromosomes to dynamic microtubule tips during cell division, thereby generating force to segregate the…”
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Inhibition of DYRK1A and GSK3B induces human β-cell proliferation by Shen, Weijun, Taylor, Brandon, Jin, Qihui, Nguyen-Tran, Van, Meeusen, Shelly, Zhang, You-Qing, Kamireddy, Anwesh, Swafford, Austin, Powers, Andrew F., Walker, John, Lamb, John, Bursalaya, Badry, DiDonato, Michael, Harb, George, Qiu, Minhua, Filippi, Christophe M., Deaton, Lisa, Turk, Carolina N., Suarez-Pinzon, Wilma L., Liu, Yahu, Hao, Xueshi, Mo, Tingting, Yan, Shanshan, Li, Jing, Herman, Ann E., Hering, Bernhard J., Wu, Tom, Martin Seidel, H., McNamara, Peter, Glynne, Richard, Laffitte, Bryan

“…Insufficient pancreatic β-cell mass or function results in diabetes mellitus. While significant progress has been made in regulating insulin secretion from…”
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A novel and translational role for autophagy in antisense oligonucleotide trafficking and activity by Ochaba, Joseph, Powers, Andrew F, Tremble, Kaitlyn A, Greenlee, Sarah, Post, Noah M, Matson, John E, MacLeod, A Robert, Guo, Shuling, Aghajan, Mariam

“…Abstract Endocytosis is a mechanism by which cells sense their environment and internalize various nutrients, growth factors and signaling molecules. This…”
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Angiotensin II injures the arterial wall causing increased aortic stiffening in apolipoprotein E-deficient mice by Tham, Doris M, Martin-McNulty, Baby, Wang, Yi-Xin, Da Cunha, Valdeci, Wilson, Dennis W, Athanassious, Christian N, Powers, Andrew F, Sullivan, Mark E, Rutledge, John C

“…Cardiovascular diseases, such as atherosclerosis and hypertension, are associated with arterial stiffening. Previous studies showed that ANG II exacerbated…”
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Direct physical study of kinetochore–microtubule interactions by reconstitution and interrogation with an optical force clamp by Franck, Andrew D., Powers, Andrew F., Gestaut, Daniel R., Davis, Trisha N., Asbury, Charles L.

“…We detail our use of computer-controlled optical traps to study interactions between kinetochore components and dynamic microtubules. Over the last two decades…”
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Measuring kinetochore-microtubule interaction in vitro by Driver, Jonathan W, Powers, Andrew F, Sarangapani, Krishna K, Biggins, Sue, Asbury, Charles L

“…Many proteins and protein complexes perform sophisticated, regulated functions in vivo. Many of these functions can be recapitulated using in vitro…”
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Synergistic effect of angiotensin II and nitric oxide synthase inhibitor in increasing aortic stiffness in mice by Fitch, Richard M, Rutledge, John C, Wang, Yi-Xin, Powers, Andrew F, Tseng, Jih-Lie, Clary, Taegan, Rubanyi, Gabor M

“…Although they are implicated on their own as risk factors for cardiovascular disease, the potential link between nitric oxide (NO) deficiency, ANG II, and…”
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Apolipoprotein E3- and Nitric Oxide–Dependent Modulation of Endothelial Cell Inflammatory Responses by Mullick, Adam E, Powers, Andrew F, Kota, Rama S, Tetali, Sarada D, Eiserich, Jason P, Rutledge, John C

“…OBJECTIVE—Although apolipoprotein E3 (apoE3) is known to be atheroprotective, its mechanisms of protection in endothelial cells remain unclear. METHODS AND…”
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2143-P: GLP-1 Conjugation Enhances the Activity of Antisense Oligonucleotides Targeting Islet Amyloid Polypeptide (IAPP) or Kelch-Like ECH Associated Protein 1 (Keap1) in Isolated Pancreatic Islets by FU, WUXIA, LEE, RICHARD, PIRIE, ELAINE C., PRAKASH, THAZHA, MURRAY, SUE, POWERS, ANDREW F., CROOKE, ROSANNE M.

“…The incidence of type 2 diabetes (T2D) is increasing rapidly and is currently one of the 21st century’s major challenges to human health. While T2D has a…”
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How Kinetochores Promote Accuracy in Mitosis: Tension, Phosphoregulation, and the Chinese ‘Finger Trap’ Effect by Asbury, Charles L., Sarangapani, Krishna K., Akiyoshi, Bungo, Duggan, Nicole, Driver, Jonathan W., Arellano-Santoyo, Hugo, Powers, Andrew F., Biggins, Sue

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Tension Directly Stabilizes Reconstituted Kinetochore-Microtubule Attachments by Asbury, Charles L., Akiyoshi, Bungo, Sarangapani, Krishna K., Powers, Andrew F., Nelson, Christian R., Reichow, Steve L., Gonen, Tamir, Ranish, Jeffrey A., Biggins, Sue

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The Ndc80 kinetochore complex uses biased diffusion to couple chromosomes to dynamic microtubule tips by Powers, Andrew F., Franck, Andrew D., Gestaut, Daniel R., Cooper, Jeremy, Gracyzk, Beth, Wei, Ronnie R., Wordeman, Linda, Davis, Trisha N., Asbury, Charles L.

“…Kinetochores couple chromosomes to the assembling and disassembling tips of microtubules, a dynamic behavior that is fundamental to mitosis in all eukaryotes…”
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Reconstitution Of Microtubule-driven Movement and Force Production by the Ndc80 Kinetochore Complex by Franck, Andrew D., Powers, Andrew F., Gestaut, Daniel R., Cooper, Jeremy, Gracyzk, Beth, Wei, Ronnie R., Wordeman, Linda, Davis, Trisha N., Asbury, Charles L.

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