Search Results - "Powell, Timothy"

Telomere Length and Bipolar Disorder by Powell, Timothy R, Dima, Danai, Frangou, Sophia, Breen, Gerome

“…Variation in telomere length is heritable and is currently considered a promising biomarker of susceptibility for neuropsychiatric disorders, particularly…”
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Translating Schizophrenia Population Genetics Findings to Neurobiological Mechanisms: The Case of KALRN-9 by Powell, Timothy R.

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Inflammatory profiles of severe treatment-resistant depression by Strawbridge, Rebecca, Hodsoll, John, Powell, Timothy R., Hotopf, Matthew, Hatch, Stephani L., Breen, Gerome, Cleare, Anthony J.

“…•Treatment-resistant depressed groups are rarely studied but may have high inflammation.•We assessed highly treatment-resistant inpatients before and after…”
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Autophagy is a critical regulator of memory CD8(+) T cell formation by Puleston, Daniel J, Zhang, Hanlin, Powell, Timothy J, Lipina, Elina, Sims, Stuart, Panse, Isabel, Watson, Alexander S, Cerundolo, Vincenzo, Townsend, Alain Rm, Klenerman, Paul, Simon, Anna Katharina

“…During infection, CD8(+) T cells initially expand then contract, leaving a small memory pool providing long lasting immunity. While it has been described that…”
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Prolactin, Estradiol and Testosterone Differentially Impact Human Hippocampal Neurogenesis in an In Vitro Model by Smeeth, Demelza M., Kourouzidou, Ioanna, Duarte, Rodrigo R.R., Powell, Timothy R., Thuret, Sandrine

“…•Human hippocampal progenitor cells (HPCs) and tissue express classical sex hormone receptors.•Prolactin does not impact human HPCs maintained in a…”
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Ancient viral DNA in the human genome linked to neurodegenerative diseases by Duarte, Rodrigo R.R., Nixon, Douglas F., Powell, Timothy R.

“…•Retrotranscriptome-wide association studies identify HERV expression signatures associated with neurodegenerative diseases.•MER61_12q14.2 and ERVLE_1p36.32a…”
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The polygenic nature of telomere length and the anti-ageing properties of lithium by Coutts, Fiona, Palmos, Alish B, Duarte, Rodrigo R R, de Jong, Simone, Lewis, Cathryn M, Dima, Danai, Powell, Timothy R

“…Telomere length is a promising biomarker for age-related disease and a potential anti-ageing drug target. Here, we study the genetic architecture of telomere…”
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Reconsidering the reasons for heightened inflammation in major depressive disorder by Palmos, Alish B., Chung, Raymond, Frissa, Souci, Goodwin, Laura, Hotopf, Matthew, Hatch, Stephani L., Breen, Gerome, Powell, Timothy R.

“…•Polygenic risk scores (PRS) for depression do not affect inflammatory marker levels.•Body mass index (BMI) and PRS for BMI correlate with IL-6 and CRP…”
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Telomere Length and Bipolar Disorder by Powell, Timothy R, Dima, Danai, Frangou, Sophia, Breen, Gerome

“…This corrects the article DOI: 10.1038/npp.2017.125…”
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Progress and challenges in maternal health in western China: a Countdown to 2015 national case study by Gao, Yanqiu, PhD, Zhou, Hong, PhD, Singh, Neha S, PhD, Powell-Jackson, Timothy, PhD, Nash, Stephen, MSc, Yang, Min, Prof, Guo, Sufang, Prof, Fang, Hai, Prof, Alvarez, Melisa Martinez, PhD, Liu, Xiaoyun, PhD, Pan, Jay, PhD, Wang, Yan, Prof, Ronsmans, Carine, Prof

“…Summary Background China is one of the few Countdown countries to have achieved Millennium Development Goal 5 (75% reduction in maternal mortality ratio…”
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Trading HIV for sheep: Risky sexual behavior and the response of female sex workers to Tabaski in Senegal by Cust, Henry, Lépine, Aurélia, Treibich, Carole, Powell‐Jackson, Timothy, Radice, Rosalba, Tidiane Ndour, Cheikh

“…We use a cohort of female sex workers (FSWs) in Senegal to show how large anticipated economic shocks lead to increased risky sexual behavior. Exploiting the…”
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Focused antibody response to influenza linked to antigenic drift by Huang, Kuan-Ying A, Rijal, Pramila, Schimanski, Lisa, Powell, Timothy J, Lin, Tzou-Yien, McCauley, John W, Daniels, Rodney S, Townsend, Alain R

“…The selective pressure that drives antigenic changes in influenza viruses is thought to originate from the human immune response. Here, we have characterized…”
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Assessing the contributions of childhood maltreatment subtypes and depression case-control status on telomere length reveals a specific role of physical neglect by Vincent, John, Hovatta, Iiris, Frissa, Souci, Goodwin, Laura, Hotopf, Matthew, Hatch, Stephani L, Breen, Gerome, Powell, Timothy R

“…Abstract Background Studies have provided evidence that both childhood maltreatment and depressive disorders are associated with shortened telomere lengths…”
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Doctor Competence and the Demand for Healthcare: Evidence from Rural China by Fe, Eduardo, Powell‐Jackson, Timothy, Yip, Winnie

“…Summary The agency problem between patients and doctors has long been emphasised in the health economics literature, but the empirical evidence on whether…”
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Integrating human endogenous retroviruses into transcriptome-wide association studies highlights novel risk factors for major psychiatric conditions by Duarte, Rodrigo R. R., Pain, Oliver, Bendall, Matthew L., de Mulder Rougvie, Miguel, Marston, Jez L., Selvackadunco, Sashika, Troakes, Claire, Leung, Szi Kay, Bamford, Rosemary A., Mill, Jonathan, O’Reilly, Paul F., Srivastava, Deepak P., Nixon, Douglas F., Powell, Timothy R.

“…Human endogenous retroviruses (HERVs) are repetitive elements previously implicated in major psychiatric conditions, but their role in aetiology remains…”
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Montelukast drug activity and potential against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) by Copertino, Dennis C., Duarte, Rodrigo R. R., Powell, Timothy R., Mulder Rougvie, Miguel, Nixon, Douglas F.

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Telomere length as a predictor of emotional processing in the brain by Powell, Timothy R., De Jong, Simone, Breen, Gerome, Lewis, Cathryn M., Dima, Danai

“…Shorter telomere length (TL) has been associated with the development of mood disorders as well as abnormalities in brain morphology. However, so far, no…”
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Preliminary Assessment of the Efficacy of a T-Cell-Based Influenza Vaccine, MVA-NP+M1, in Humans by Lillie, Patrick J., Berthoud, Tamara K., Powell, Timothy J., Lambe, Teresa, Mullarkey, Caitlin, Spencer, Alexandra J., Hamill, Matthew, Peng, Yanchun, Blais, Marie-Eve, Duncan, Christopher J. A., Sheehy, Susanne H., Havelock, Tom, Faust, Saul N., Williams, Rob Lambkin, Gilbert, Anthony, Oxford, John, Dong, Tao, Hill, Adrian V. S., Gilbert, Sarah C.

“…Background. The novel influenza vaccine MVA-NP+M1 is designed to boost cross-reactive T-cell responses to internal antigens of the influenza A virus that are…”
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Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons by Aabdien, Afra, Sichlinger, Laura, Borgel, Zoe, Jones, Madeleine R., Waston, Iain A., Gatford, Nicholas J. F., Raval, Pooja, Tanangonan, Lloyd, Powell, Timothy R., Duarte, Rodrigo R. R., Srivastava, Deepak P.

“…The zinc finger protein 804A (ZNF804A) and the 5′‐nucleotidase cytosolic II (NT5C2) genes are amongst the first schizophrenia susceptibility genes to have been…”
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Telomere length and human hippocampal neurogenesis by Palmos, Alish B, Duarte, Rodrigo R R, Smeeth, Demelza M, Hedges, Erin C, Nixon, Douglas F, Thuret, Sandrine, Powell, Timothy R

“…Short telomere length is a risk factor for age-related disease, but it is also associated with reduced hippocampal volumes, age-related cognitive decline and…”
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