Search Results - "Powell, Kerrington"

The Kardashian Index: a study of researchers' opinions on twitter 2014–2021 by Powell, Kerrington, Haslam, Alyson, Prasad, Vinay

“…The Kardashian Index was designed for comedic purposes and meant to highlight researchers with minimal scholar contribution but oversized social media…”
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Concerning FDA approval of trilaciclib (Cosela) in extensive-stage small-cell lung cancer by Powell, Kerrington, Prasad, V

“…•Trilaciclib has a high level of bioplausibility, however further study is necessary.•Many concerns remain about the evidence used to approve…”
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A novel trial methodology to test interventions with very large effect sizes: the case of dostarlimab in mismatch repair-deficient, locally advanced rectal cancer by Powell, Kerrington, Olivier, Timothée, Prasad, Vinay

“…Dostarlimab (Jemperli, GlaxoSmithKline) is an anti-programmed death receptor-1 monoclonal antibody (anti-PD-1) recently tested in a non-randomized, phase II…”
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The AGILE trial of ivosidenib plus azacitidine versus azacitidine alone: How many limitations is too many? by Bhatt, Anjali, Powell, Kerrington, Prasad, Vinay

“…•Post-protocol therapy was suboptimal.•The control arm of AGILE does not reflect the current standard of care.•The primary endpoint of AGILE was changed, and…”
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How Often do Medical Specialties Question the Practices that They Perform? An Empirical, Cross-Sectional Analysis of the Published Literature by Haslam, Alyson, Powell, Kerrington, Prasad, Vinay

“…An aspect of overuse is who decides which practices are evaluated for overuse and which of the studies on overuse are published in the medical literature. We…”
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Exploring the gender gap in neurosurgery: A cross‐sectional analysis of preresidency publications among neurosurgery residents by Hassan, Taimur, Kakkilaya, Akash, Huang, Annie, Kakkilaya, Apoorva, Downey, Kristen, Powell, Kerrington

“…Background and Aims While the number of female physicians has increased since the 1970s, there continues to be a lack of female surgeons compared to their male…”
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Where are randomized trials necessary: Are smoking and parachutes good counterexamples? by Powell, Kerrington, Prasad, Vinay

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Common misconceptions of randomized controlled trials in oncology by Powell, Kerrington, Prasad, Vinay

“…In biomedicine, randomized controlled trials are regarded as the gold standard of evidence owing to their ability to minimize confounding factors that may…”
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Multiplicity: When many analytic plans are applied or many redundant studies are run, false‐positive results are ensured by Powell, Kerrington, Prasad, Vinay

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Lutetium-177-PSMA-617 in Metastatic Castration-resistant Prostate Cancer: Limitations of the VISION Trial by Olivier, Timothée, Powell, Kerrington, Prasad, Vinay

“…Lu-PSMA was approved in the USA for patients with prostate-specific membrane antigen–positive metastatic castration-resistant prostate cancer already treated…”
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An Empirical Analysis of Precision Previvorship: Are Familial and High-Risk Cancer Preventive Programs Evidence Based? by Powell, Kerrington, Haslam, Alyson, Prasad, Vinay

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Relugolix: Five Reasons Why the US Food and Drug Administration Should Have Exercised Restraint by Powell, Kerrington, Burns, Michael C., Prasad, Vinay

“…We highlight concerns regarding the approval of relugolix for patients with prostate cancer. These include the unsuitable comparator arm and primary endpoint…”
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Old-fashioned Intelligence Will Always Be Needed in Medicine by Powell, Kerrington, Prasad, Vinay

“…Artificial intelligence is new and enticing, but the idea that it will make physicians expendable is hyperbole. Medicine is a moral art that balances values…”
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Eventual success rate and predictors of success for oncology drugs tested in phase I trials by Haslam, Alyson, Olivier, Timothée, Powell, Kerrington, Tuia, Jordan, Prasad, Vinay

“…Previous estimates of the likelihood of a drug tested in phase I trials obtaining FDA clearance are out of date. In the intervening years, newer…”
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The role of surgery in metastatic cancer: the case for a pragmatic tumor-agnostic randomized trial by Powell, Kerrington, Marquart, John, Olivier, Timothée, Prasad, Vinay

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Idecabtagene vicleucel: questions regarding the appropriate role and cost by Powell, Kerrington, Russler‐Germain, David, Prasad, Vinay

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Financial conflicts of interest of physicians followed by neurosurgical journals on Twitter by Powell, Kerrington, McCall, Kyle, Hooda, Karan, Prasad, Vinay, Kakkilaya, Akash

“…Background Social media, particularly Twitter, has played an increasing role in networking and the dissemination of neurosurgical research. Despite extensive…”
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The Oncologic Drugs Advisory Committee Votes of April 2021-Implications for the Fate of Accelerated Approval by Powell, Kerrington, Lythgoe, Mark P, Prasad, Vinay

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Financial conflicts of interest of physicians followed by oncology journals on Twitter by Betts, Colton, Kakkilaya, Akash, Vasireddy, Satvik, Arora, Neha, Prasad, Vinay, Powell, Kerrington

“…Background Physicians have increasingly adopted Twitter as a discussion and distribution platform for oncology research. While the influence of financial…”
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Characteristics of oncology podcasts: Attitudes, speakers, conflicts by Akman, Emma Greenstreet, Powell, Kerrington, Haslam, Alyson, Prasad, Vinay

“…To systematically appraise the content within oncology podcasts and the individuals who speak on them. A cross-sectional study. We obtained a list of 33…”
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